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The observations suggest that MD-2 helps to regulate lipopolysaccharide-induced NLRP3 (zeige NLRP3 ELISA Kits) inflammasome activation and the inflammatory response in NR8383 cells, and likely does so by affecting MyD88 (zeige MYD88 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits) signaling.
MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases.
we report that exogenous CnB (zeige PPP3R1 ELISA Kits) is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (zeige TLR4 ELISA Kits)/MD2 complex together with the co-receptor CD14 (zeige NDUFA2 ELISA Kits)
In this study, a novel naturally occurring spliceosome of human MD2, termed as MD2-T3, has been identified.
Results show that cigarette smoke may alter innate immune responses reducing the expression of the MD2, a molecule with an important role in TLR4 (zeige TLR4 ELISA Kits) signaling.
Predominantly hydrophobic interactions between MD-2 and TLR4 (zeige TLR4 ELISA Kits) contribute to the stabilization of the TLR4 (zeige TLR4 ELISA Kits)/MD-2/metal ion complex in a conformation that enables activation.
The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 (zeige TLR4 ELISA Kits) ligands may be facilitated through synthesis and release of sMD2 (zeige SNRPD2 ELISA Kits) by the amniochorion.
Three genes (LY96, IL8 (zeige IL8 ELISA Kits) DPR (zeige DACT1 ELISA Kits)) were significantly downregulated over time. This finding was confirmed in a validation cohort of stroke patients (n=8).
The study revealed the impact of specific residues and regions of MD-2 on the binding of lipolysaccharides and TLR4 (zeige TLR4 ELISA Kits).
Gene polymorphisms of MD2 and GM2A (zeige GM2A ELISA Kits) were associated with the occurrence or severity of neonatal necrotizing enterocolitis.
Data suggest that C4bp prevents interaction between Tlr4 (zeige TLR4 ELISA Kits)/MD-2 and its ligand; C4bp does not appear to interact with Tlr3 (zeige TLR3 ELISA Kits); C4bp binds to macrophage surface Tlr4 (zeige TLR4 ELISA Kits) and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 (zeige TLR4 ELISA Kits) activation. (C4bp = complement component 4 binding protein; Tlr = toll (zeige TLR4 ELISA Kits)-like receptor; MD-2 = myeloid differentiation protein-2)
Oxidative stress in retinal ischemia-reperfusion injury activates TLR4 (zeige TLR4 ELISA Kits) signaling via MD2.
Neoseptin-3 and lipid A form dissimilar molecular contacts to achieve receptor activation; hence strong TLR4 (zeige TLR4 ELISA Kits)/MD-2 agonists need not mimic LPS (zeige TLR4 ELISA Kits)
Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 (zeige TLR4 ELISA Kits) ancillary molecule.
MD-2 is a critical regulator of the establishment of allergic airway sensitization to HDM (zeige HDAC3 ELISA Kits) in mice. Serum MD-2 may represent a potential biomarker for the amplification of allergic sensitization and allergic inflammation.
Data show that myeloid differentiation factor 2 (MD-2) binds specifically to disulfide isoform of box protein 1, high mobility group (zeige SSRP1 ELISA Kits) (HMGB1 (zeige HMGB1 ELISA Kits)) to facilitate toll-like receptor 4 (TLR4 (zeige TLR4 ELISA Kits))-dependent signaling.
Carbon monoxide treatment reduces the expression of the TLR4 (zeige TLR4 ELISA Kits)/MD2 complex on the surface of myeloid cells, which renders them resistant to lipopolysaccharide priming in vitro, as well as in vivo in a model of endotoxic shock.
Mechanistically, engagement of MD-2 by PTX3 (zeige PITX3 ELISA Kits)-opsonized Aspergillus conidia activated the TLR4/Toll (zeige TLR4 ELISA Kits)/IL-1R domain-containing adapter inducing IFN-beta (zeige IFNB1 ELISA Kits)-dependent signaling pathway converging on IL-10 (zeige IL10 ELISA Kits).
SAA3 (zeige SAA3 ELISA Kits) directly binds MD-2 and activates the MyD88 (zeige MYD88 ELISA Kits)-dependent TLR4 (zeige TLR4 ELISA Kits)/MD-2 pathway.
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms.
myeloid differentiation protein-2
, protein MD-2
, myeloid differentiation factor-2
, LPS co-receptor MD-2
, lymphocyte antigen 96
, Protein MD-2