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SNCA Proteine

(Synuclein, alpha (SNCA))

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].

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SNCA Protein (full length)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95% pure using SDS-PAGE analysis. SDS, WB, in vitro, in vivo Active

SDS-PAGE of ~14 kDa Active Human Recombinant Alpha Synuclein Protein Aggregate .

Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) (Catalog No.

Primary rat hippocampal neurons show lewy body inclusion formation when treated with active Alpha Synuclein Protein Aggregate at 4 µg/ml (D-F), but not when treated with control Alpha Synuclein Protein Aggregate at 4 µg/ml (A-C).

Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (ABIN5065829, ABIN5065830 and ABIN5564165) at 4 μg/mL (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (ABIN5065829, ABIN5065830 and ABIN5564165) at 4 μg/mL (A-C).

ATTO633 fluorescently-labelled alpha synuclein PFFs (ABIN5065829, ABIN5065830 and ABIN5564165) were taken up, transported into the soma, and induced alpha synuclein aggregation in mouse neurocortical primary cells.

Confocal imaging shows NeuN+ (mature) primary cortical neurons filled with ATTO633 fluorescently-labelled alpha synuclein PFFs (ABIN5065829, ABIN5065830 and ABIN5564165).

Immunohistochemistry analysis of rat brain injected with Type 1 human alpha synuclein PFFs (ABIN5065829, ABIN5065830 and ABIN5564165).

TEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (ABIN5065829, ABIN5065830 and ABIN5564165)

Type 1 alpha synuclein Pre-formed Fibrils (ABIN5065829, ABIN5065830 and ABIN5564165) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (ABIN5065829, ABIN5065830 and ABIN5564165).

TEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (ABIN5065829, ABIN5065830 and ABIN5564165)

10 Abbildungen

Produktnummer ABIN5065829

-20% for 20 Years of ABO

547,20 €

~~684,00 €~~

Sparen Sie 136,80 € (-20 %)

Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt

100 μg

Lieferung nach: Deutschland

Lieferung in 7 bis 10 Werktagen

SNCA Protein (A53T)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active

Primary rat hippocampal neurons show lewy body inclusion formation when treated with A53T mutant Alpha Synuclein Protein Pre-formed Fibrils (ABIN6952303, ABIN6952304 and ABIN6952305) (B) but not when treated with a media control (A).

Evaluation of a-syn toxicity on primary mouse cortical neurons.

TEM of A53T alpha synuclein Pre-formed Fibrils (ABIN6952303, ABIN6952304 and ABIN6952305)

TEM of A53T alpha synuclein Pre-formed Fibrils (ABIN6952303, ABIN6952304 and ABIN6952305)

Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures such as those in alpha synuclein fibrils.

Evaluation of a-syn toxicity on primary mouse cortical neurons.

6 Abbildungen

Produktnummer ABIN6952303

-20% for 20 Years of ABO

547,20 €

~~684,00 €~~

Sparen Sie 136,80 € (-20 %)

Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt

100 μg

Lieferung nach: Deutschland

Lieferung in 7 bis 10 Werktagen

SNCA Protein (full length)

SNCA Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active

SDS-PAGE of ~14 kDa Type 1 Mouse Recombinant Alpha Synuclein Protein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247).

TEM of Type 1 mouse alpha synuclein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247).

Primary rat hippocampal neurons show lewy body inclusion formation and loss of cells when treated with Type 1 mouse Alpha Synuclein Protein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247) at 4 μg/mL (D-F) on DVI2, but not when treated with a control (A-C).

C57/BL6 mice were injected with sonicated recombinant mouse alpha synuclein monomers or fibrils at 8 weeks of age.

C57/BL6 mice were injected with 5 μg sonicated mouse recombinant alpha synuclein PFFs (ABIN5651245, ABIN5651246 and ABIN5651247) at 8 weeks of age.

Immunohistochemistry analysis of rat brain injected with Type 1 mouse alpha synuclein PFFs (ABIN5651245, ABIN5651246 and ABIN5651247).

Primary mouse hippocampal neurons treated with 100 nM sonicated mouse alpha synuclein PFFs (ABIN5651245, ABIN5651246 and ABIN5651247) (A).

TEM of Type 1 mouse alpha synuclein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247).

Type 1 alpha synuclein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (ABIN5651245, ABIN5651246 and ABIN5651247).

9 Abbildungen

Produktnummer ABIN5651245

-20% for 20 Years of ABO

547,20 €

~~684,00 €~~

Sparen Sie 136,80 € (-20 %)

Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt

100 μg

Lieferung nach: Deutschland

Lieferung in 7 bis 10 Werktagen

SNCA Protein

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS

SDS-PAGE (SDS) image for Synuclein, alpha (SNCA) protein (ABIN666814)

1 image

Produktnummer ABIN666814

-20% for 20 Years of ABO

587,70 €

~~734,62 €~~

Sparen Sie 146,92 € (-20 %)

Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt

100 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 12 bis 16 Werktagen

SNCA Protein (AA 1-140) (His tag)

SNCA Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA

Western Blotting (WB) image for Synuclein, alpha (SNCA) (AA 1-140) protein (His tag) (ABIN7125301)

1 image

Produktnummer ABIN7125301

-20% for 20 Years of ABO

335,75 €

~~419,69 €~~

Sparen Sie 83,94 € (-20 %)

Zzgl. Versandkosten 20,00 € und MwSt

50 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 11 bis 15 Werktagen

SNCA Protein (AA 1-140) (His-IF2DI Tag)

SNCA Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA

Western Blotting (WB) image for Synuclein, alpha (SNCA) (AA 1-140) protein (His-IF2DI Tag) (ABIN7125300)

1 image

Produktnummer ABIN7125300

-20% for 20 Years of ABO

335,75 €

~~419,69 €~~

Sparen Sie 83,94 € (-20 %)

Zzgl. Versandkosten 20,00 € und MwSt

50 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 11 bis 15 Werktagen

SNCA Protein (active)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % pure SDS

Figure annotation denotes ug of protein loaded and % gel used.

1 image

Produktnummer ABIN934871

-20% for 20 Years of ABO

482,13 €

~~602,66 €~~

Sparen Sie 120,53 € (-20 %)

Zzgl. Versandkosten 20,00 € und MwSt

100 μg

Lieferung nach: Deutschland

Lieferung in 20 bis 27 Werktagen

SNCA Protein (AA 31-140) (GST tag)

SNCA Spezies: Human Wirt: Wheat germ Recombinant AP, AA, ELISA, WB

Image no. 1 for Synuclein, alpha (SNCA) (AA 31-140) protein (GST tag) (ABIN1320776)

1 image

Produktnummer ABIN1320776

-20% for 20 Years of ABO

499,20 €

~~624,00 €~~

Sparen Sie 124,80 € (-20 %)

Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt

10 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 8 bis 9 Werktagen

SNCA Protein (AA 1-140) (GST tag)

SNCA Spezies: Human Wirt: Wheat germ Recombinant AP, AA, ELISA, WB

Image no. 1 for Synuclein, alpha (SNCA) (AA 1-140) protein (GST tag) (ABIN1320774)

1 image

Produktnummer ABIN1320774

-20% for 20 Years of ABO

499,20 €

~~624,00 €~~

Sparen Sie 124,80 € (-20 %)

Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt

10 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 8 bis 9 Werktagen

SNCA Protein (AA 1-140)

SNCA Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE. ELISA Active

Western Blotting (WB) image for Synuclein, alpha (SNCA) (AA 1-140) (Active) protein (ABIN7320688)

1 image

Produktnummer ABIN7320688

-20% for 20 Years of ABO

162,88 €

~~203,60 €~~

Sparen Sie 40,72 € (-20 %)

Zzgl. Versandkosten 20,00 € und MwSt

50 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 9 bis 13 Werktagen

SNCA Protein (AA 1-139, partial) (GST tag)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 90 % SDS, ELISA

SDS-PAGE (SDS) image for Synuclein, alpha (SNCA) (AA 1-139), (partial) protein (GST tag) (ABIN1046507)

1 image

3 Referenzen

Produktnummer ABIN1046507

460,90 €

Zzgl. Versandkosten 20,00 € und MwSt

100 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 11 bis 15 Werktagen

SNCA Protein (AA 23-140) (His tag)

SNCA Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, Imm, PC

Produktnummer ABIN7405657

-20% for 20 Years of ABO

633,08 €

~~791,35 €~~

Sparen Sie 158,27 € (-20 %)

Zzgl. Versandkosten 20,00 € und MwSt

100 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 11 bis 15 Werktagen

SNCA Protein (AA 23-140) (His tag)

SNCA Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, Imm, PC

Produktnummer ABIN7393487

-20% for 20 Years of ABO

623,16 €

~~778,95 €~~

Sparen Sie 155,79 € (-20 %)

Zzgl. Versandkosten 20,00 € und MwSt

100 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 11 bis 15 Werktagen

SNCA Protein (phosphorylated) (His tag)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant

Produktnummer ABIN7857338

-20% for 20 Years of ABO

590,28 €

~~737,85 €~~

Sparen Sie 147,57 € (-20 %)

Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt

100 μg

Lieferung nach: Deutschland

Lieferung in 8 bis 12 Werktagen

SNCA Protein (AA 1-140)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.

Produktnummer ABIN1692153

-20% for 20 Years of ABO

171,66 €

~~214,57 €~~

Sparen Sie 42,91 € (-20 %)

Zzgl. Versandkosten 20,00 € und MwSt

50 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 8 bis 10 Werktagen

SNCA Protein (His tag)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant

Produktnummer ABIN7857337

-20% for 20 Years of ABO

340,43 €

~~425,54 €~~

Sparen Sie 85,11 € (-20 %)

Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt

100 μg

Lieferung nach: Deutschland

Lieferung in 8 bis 12 Werktagen

SNCA Protein (AA 1-140)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant

Produktnummer ABIN7890583

-20% for 20 Years of ABO

117,52 €

~~146,90 €~~

Sparen Sie 29,38 € (-20 %)

Zzgl. Versandkosten 20,00 € und MwSt

10 μg

Lieferung nach: Deutschland

Lieferung in 8 bis 10 Werktagen

SNCA Protein (AA 1-140) (Strep Tag)

custom-made SNCA Spezies: Human Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA

Produktnummer ABIN3073847

ab

15.754,29 €

Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt

250 μg

Lieferung nach: Deutschland

Lieferung in 51 bis 61 Werktagen

SNCA Protein (AA 1-140) (Strep Tag)

custom-made SNCA Spezies: Maus Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA

Produktnummer ABIN3131854

ab

15.754,29 €

Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt

250 μg

Lieferung nach: Deutschland

Lieferung in 51 bis 61 Werktagen

SNCA Protein (A53T, AA 1-140)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active

Produktnummer ABIN7827836

200,30 €

Zzgl. Versandkosten 20,00 € und MwSt

100 μg

Lieferung nach: Deutschland

Lieferung in 7 bis 11 Werktagen

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