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anti-Human NMDAR2A Antikörper:
anti-Rat (Rattus) NMDAR2A Antikörper:
anti-Mouse (Murine) NMDAR2A Antikörper:
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Mammalian Monoclonal NMDAR2A Primary Antibody für ISt, IHC - ABIN1304680
DOrsi, Kilbride, Chen, Perez Alvarez, Bonner, Pfeiffer, Plesnila, Engel, Henshall, Düssmann, Prehn: Bax regulates neuronal Ca2+ homeostasis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
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Human Polyclonal NMDAR2A Primary Antibody für IF (p), IHC (p) - ABIN747353
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. in Neurobiology of disease 2014
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Mouse (Murine) Monoclonal NMDAR2A Primary Antibody für IF, WB - ABIN968802
Ishii, Moriyoshi, Sugihara, Sakurada, Kadotani, Yokoi, Akazawa, Shigemoto, Mizuno, Masu: Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. in The Journal of biological chemistry 1993
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Rat (Rattus) NMDAR2A Primary Antibody für ELISA, WB - ABIN1742591
Wang, Liu, Fu, Wang, Lu: Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. in Nature neuroscience 2003
2-methoxyestradiol impacts on glycine/serine-mediated metabolic reprogramming in osteosarcoma cells by its interaction with GRIN1 (zeige GRIN1 Antikörper)/GluN2A receptors.
a de novo missense mutation in the GRIN2A gene in a patient with childhood focal epilepsy and acquired epileptic aphasia. The mutant decreases NMDAR (zeige GRIN1 Antikörper) activation suggesting NMDAR (zeige GRIN1 Antikörper) hypofunction may contribute to the epilepsy pathogenesis.
genetic association studies in population in China: Data suggest that one SNP in GRIN2A (rs2650429; but not rs6497540 or rs9302415) is associated with lead-induced neurotoxicity; in this case-control study, cases were lead-exposed workers from battery plants. Lead-exposed individuals have lower serum GRIN2A levels compared with controls; lead decreases GRIN2A expression levels in HEK293 cell.
Two adjacent phenylalanines in the NMDA receptor GluN2A subunit M3 domain interactively regulate alcohol sensitivity and ion channel gating.
The GRIN2A genotype was not associated with the rate of clinical progression of PD in the placebo group.
most rare variants in GluN2A were associated with epilepsy, whereas GluN2B (zeige GRIN2B Antikörper) variants were associated with intellectual disability with or without seizures
the gain-of-function M817V mutation causes overactivation of NMDAR (zeige GRIN1 Antikörper) and drives neuronal hyperexcitability.
To determine genetic variability within the N-methyl-D-aspartate receptor 2A sub-unit (GRIN2A) gene promoter and its association with concussion recovery time.
Knockdown of PKD1 (zeige PKD1 Antikörper) did not affect NMDAR (zeige GRIN1 Antikörper) internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR (zeige GRIN1 Antikörper)-mediated synaptic functions.
Findings suggest that mutations in GRIN2A preferentially are involved in genetic variance of pediatric idiopathic generalized epilepsy and do not contribute significantly to either adult focal epilepsies as temporal lobe epilepsy or generalized epilepsies
Drebrin A (zeige DBN1 Antikörper) can be found co-clustering with NR2B (zeige GRIN2B Antikörper)-containing NMDARs at the plasma membrane, while NR2A-containing NMDARs co-traffic into the spine cytoplasm but do not co-cluster at the plasma membrane.
This study demonstrated that Increasing the GluN2A/GluN2B (zeige GRIN2B Antikörper) Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace.
Grin2aPKC mice exhibit reduced anxiety in the open field test, light dark emergence test, and elevated plus maze. Overall, these results suggest that at least one of those PKC (zeige PKC Antikörper)-mediated phosphorylation sites regulates NMDAR (zeige GRIN1 Antikörper)-mediated signaling that modulates anxiety.
These data suggest that chronic early postnatal SSS influences spatial learning and memory ability, levels of hippocampal NR2B (zeige GRIN2B Antikörper), and NR2A/NR2B (zeige GRIN2B Antikörper) ratios in adult males.
Rph3A (zeige RPH3A Antikörper) interacts with GluN2A and PSD-95 (zeige DLG4 Antikörper) forming a complex that regulates NMDARs stabilization at postsynaptic membranes.
Egr-1 (zeige EGR1 Antikörper) is involved in NMDAR (zeige GRIN1 Antikörper)-mediated PSD-95 (zeige DLG4 Antikörper) down-regulation and AMPAR endocytosis, a process important in the expression of long term depression
Study demonstrated that GluN2A carboxy-terminal domain is responsible for the impaired long-term olfactory and social memory observed in the GluN2A overexpression mice
Results establish the GluN2A subunit as a significant contributor to both bidirectional synaptic plasticity and spatial pattern separation in the dentate gyrus
Best1 (zeige BEST1 Antikörper)-mediated astrocytic glutamate (zeige GRIN1 Antikörper) activates the synaptic N-methyl-D-aspartate receptor (zeige GRIN1 Antikörper) (NMDAR (zeige GRIN1 Antikörper)) and modulates NMDAR (zeige GRIN1 Antikörper)-dependent synaptic plasticity.
Data suggest a role for GluN2A in ethanol tolerance.
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
N-methyl-D-aspartate receptor subunit NR2A
, glutamate receptor, ionotropic, N-methyl D-aspartate 2A
, glutamate [NMDA] receptor subunit epsilon-1-like
, N-methyl D-aspartate receptor subtype 2A
, N-methyl-D-aspartate receptor channel, subunit epsilon-1
, N-methyl-D-aspartate receptor subunit 2A
, NMDA receptor subtype 2A
, glutamate [NMDA] receptor subunit epsilon-1
, glutamate receptor ionotropic, NMDA 2A
, glutamate [NMDA] receptor subunit epsilon 1
, glutamate receptor, ionotropic, N-methyl-D-aspartate subunit 2A