anti-CDK5R1 (CDK5R1) Antikörper

Bezeichnung:
anti-Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) Antikörper (CDK5R1)
Auf www.antikoerper-online.de finden Sie aktuell 106 Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) Antikörper von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDK5R1 Kits (13) und CDK5R1 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 136 CDK5R1 Produkte verfügbar.
Synonyme:
1110014C03Rik, CDK5P35, Cdk5r, CDK5R1, D11Bwg0379e, NCK5A, p23, p24delta1, p25, P25/P35, p35, p35nck5a, PCHK23, TCTP, Tmp21, Xp35.1, zgc:92814

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anti-Human CDK5R1 Antikörper:

anti-Mouse (Murine) CDK5R1 Antikörper:

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Am meisten referenzierte anti-CDK5R1 Antikörper

  1. Chicken Monoclonal CDK5R1 Primary Antibody für AA, ELISA - ABIN361805 : Shimamura, Perera, Foley, Sang, Rodig, Inoue, Chen, Li, Carretero, Li, Sinha, Carey, Borgman, Jimenez, Meyerson, Ying, Barsoum, Wong, Shapiro: Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012 (PubMed)
    Zeige alle 9 Referenzen für 361805

  2. Mouse (Murine) Monoclonal CDK5R1 Primary Antibody für IF, WB - ABIN968820 : Forsythe, Jarvis, Turner, Elmore, Holt: Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. in The Journal of biological chemistry 2001 (PubMed)
    Zeige alle 4 Referenzen für 968820

  3. Chicken Monoclonal CDK5R1 Primary Antibody für AA, ELISA - ABIN2486462 : Nair, Toran, Rimerman, Hjermstad, Smithgall, Smith: A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. in Cell stress & chaperones 1997 (PubMed)
    Zeige alle 2 Referenzen für 2486462

  4. Chicken Monoclonal CDK5R1 Primary Antibody für AA, ELISA - ABIN2486459 : Hu, Toft, Anselmo, Wang: In vitro reconstitution of functional hepadnavirus reverse transcriptase with cellular chaperone proteins. in Journal of virology 2001 (PubMed)
    Zeige alle 2 Referenzen für 2486459

  5. Human Polyclonal CDK5R1 Primary Antibody für IF, ELISA - ABIN1533901 : Tsai, Delalle, Caviness, Chae, Harlow: p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. in Nature 1994 (PubMed)
    Zeige alle 2 Referenzen für 1533901

Weitere Antikörper gegen CDK5R1 Interaktionspartner

Zebrafish Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) Interaktionspartner

  1. p35 likely acts downstream of egr1 (zeige EGR1 Antikörper) to control the differentiation of Parvalbumin (zeige PVALB Antikörper)+ amacrine cells.

Pig (Porcine) Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) Interaktionspartner

  1. CDK5 (zeige CDK5 Antikörper) mRNA reaches the highest level in cerebral cortex at two months of age and in cerebellum and liver at 4 months of age, respectively, whereas the peak level of CDK5R1 was observed in both cerebral cortex and cerebellum at two months of age

Human Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) Interaktionspartner

  1. It is shown that p5 binds the kinase at the same CDK5 (zeige CDK5 Antikörper)/p25 (zeige LCN2 Antikörper) and CDK5 (zeige CDK5 Antikörper)/p35 (zeige ANXA1 Antikörper) interfaces, and is thus a non-selective competitor of both activators, in agreement with available experimental data in vitro.

  2. the minor allele of CDK5R1 3'-UTR (zeige UTS2R Antikörper) rs735555 polymorphism was associated with increased risk for NS-ID. In conclusion, our data suggest that mutations and polymorphisms in CDK5 (zeige CDK5 Antikörper) and CDK5R1 genes may contribute to the onset of the NS-ID phenotype

  3. Under cell-free in vitro conditions, p35 (zeige ANXA1 Antikörper) is covalently modified by SUMO1 (zeige SUMO1 Antikörper). SUMO2 (zeige SUMO2 Antikörper) is conjugated to p35 (zeige ANXA1 Antikörper) in cells. The 2 major SUMO acceptor lysines in p35 (zeige ANXA1 Antikörper) are K246 and K290. Different degrees of oxidative stress resulted in differential p35 (zeige ANXA1 Antikörper) sumoylation.

  4. Cdk5 (zeige CDK5 Antikörper)/p35 (zeige ANXA1 Antikörper) is required for motor learning and involved in long-term synaptic plasticity.

  5. Expression of p35 (zeige ANXA1 Antikörper) is upregulated in human pituitary adenomas.

  6. These results reveal a physiological role of p25 (zeige LCN2 Antikörper) production in synaptic plasticity and memory and provide new insights into the function of p25 (zeige LCN2 Antikörper) in Abeta (zeige APP Antikörper)-associated neurotoxicity and Alzheimer's disease-like pathology.

  7. Structural basis for the different stability and activity between the Cdk5 (zeige CDK5 Antikörper) complexes with p35 (zeige ANXA1 Antikörper) and p39 (zeige JUN Antikörper) activators.

  8. Reduced p35 (zeige ANXA1 Antikörper) basal content and down--regulation of CDK5 (zeige CDK5 Antikörper)/p35/p25 by antipsychotics are demonstrated in postmortem prefrontal cortex of schizophrenic subjects.

  9. The present study dissects the role of 3 single nucleotide polymorphisms (rs334558 and rs6438552 of GSK3B (zeige GSK3b Antikörper), and rs735555 of CDK5R1) in Parkinson's disease pathogenesis among eastern Indians.

  10. p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity.

Mouse (Murine) Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) Interaktionspartner

  1. It suggests that ectopic increase of Cdk5 kinase activity through conversion of p35 to p25 is involved in the process of neuronal death induced by hypoxia.

  2. Loss of endothelial NO plays an important role in the generation of p25 and resulting tau phosphorylation in neuronal tissue. Endothelial nitric oxide synthase (eNOS (zeige NOS3 Antikörper))-deficient (eNOS (zeige NOS3 Antikörper)-/-) mice display increased levels of p25, an aberrant activator of cyclin-dependent kinase 5 (zeige CDK5 Antikörper), which is one of the primary kinases responsible for tau hyperphosphorylation, and a statistically higher p25/p35 ratio.

  3. The transiently active CDK5 (zeige CDK5 Antikörper)-p35 complexes limited the LPS (zeige TLR4 Antikörper)-stimulated phosphorylation and activation of various mitogen-activated protein kinases (MAPKs), thereby preventing the premature production of SOCS3 (suppressor of cytokine signaling 3 (zeige SOCS3 Antikörper))

  4. Cdk5 (cyclin-dependent kinase 5 (zeige CDK5 Antikörper)) requires p35 regulatory subunit (Cdk5r1) for activation; data suggest Cdk5r1 stability regulates Cdk5 (zeige CDK5 Antikörper) activity in neurons; Cdk5r1 is rapidly degraded by 2 proteasome methods, ubiquitination-dependent and -independent.

  5. These data suggest p35 and p39 (zeige ATP6V0D1 Antikörper) have specific and overlapping roles in oligodendrocyte development, some of which may be independent of Cdk5 (zeige CDK5 Antikörper) activation.

  6. Studied the effect of reduced levels of p25 and p35, two proteins required for cdk5 (zeige CDK5 Antikörper) activation, on striatal neurodegeneration using mice with targeted deletion of p35.

  7. p35 interacts with NIF-1 (zeige ZNF335 Antikörper) and regulates the subcellular localization of the protein independent of Cdk5 (zeige CDK5 Antikörper)-dependent phosphorylation. ...reveal a new mechanism of p35 in transcriptional regulation that does not require the kinase activity of Cdk5 (zeige CDK5 Antikörper)

  8. Cdk5 (zeige CDK5 Antikörper)/p35 regulates spatial learning and memory.

  9. Our findings suggest that p35/Rac1 signaling is critical in the CDK5 (zeige CDK5 Antikörper) silencing-induced neuroprotection against glutamate (zeige GRIN1 Antikörper) neurotoxicity

  10. provide a mechanistic explanation that Sig-1Rs help maintain proper tau phosphorylation by potentially carrying and providing myristic acid to p35 for enhanced p35 degradation to circumvent the formation of overreactive cdk5/p25

Cow (Bovine) Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) Interaktionspartner

  1. Data suggest that up-regulation of S100A8 (zeige S100A8 Antikörper) and S100A9 (zeige S100A9 Antikörper) is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.

CDK5R1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Alternative names and synonyms associated with CDK5R1

  • cyclin-dependent kinase 5, regulatory subunit 1 (p35) (cdk5r1-a) Antikörper
  • cyclin-dependent kinase 5, regulatory subunit 1b (p35) (cdk5r1b) Antikörper
  • cyclin-dependent kinase 5, regulatory subunit 1 (p35) (CDK5R1) Antikörper
  • cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1) Antikörper
  • related RAS viral (r-ras) oncogene homolog (Rras) Antikörper
  • S100 calcium binding protein A9 (S100A9) Antikörper
  • transmembrane emp24-like trafficking protein 10 (yeast) (Tmed10) Antikörper
  • tumor protein, translationally-controlled 1 (TPT1) Antikörper
  • 1110014C03Rik Antikörper
  • CDK5P35 Antikörper
  • Cdk5r Antikörper
  • CDK5R1 Antikörper
  • D11Bwg0379e Antikörper
  • NCK5A Antikörper
  • p23 Antikörper
  • p24delta1 Antikörper
  • p25 Antikörper
  • P25/P35 Antikörper
  • p35 Antikörper
  • p35nck5a Antikörper
  • PCHK23 Antikörper
  • TCTP Antikörper
  • Tmp21 Antikörper
  • Xp35.1 Antikörper
  • zgc:92814 Antikörper

Bezeichner auf Proteinebene für CDK5R1

cyclin-dependent kinase 5, regulatory subunit 1 (p35) , cyclin-dependent kinase 5 regulatory subunit , cyclin-dependent kinase 5 activator 1 , cyclin-dependent kinase 5 regulatory subunit 1 , CDK5 activator 1 , TPKII regulatory subunit , neuronal CDK5 activator , regulatory partner for CDK5 kinase , tau protein kinase II 23kDa subunit , cyclin-dependent kinase 5, regulatory subunit (p35) 1 , p23 , tau protein kinase II 23 kDa subunit , Harvey rat sarcoma oncogene, subgroup R , Harvey rat sarcoma virus oncogene, subgroup R , Ras-related protein R-RAS (P23) , ras-related protein R-Ras , BEE22 , S100 calcium-binding protein A9 , calgranulin-B , neutrophil cytosolic 23 kDa protein , protein S100-A9 , 21 kDa transmembrane-trafficking protein , p24 family protein delta-1 , transmembrane emp24 domain-containing protein 10 , transmembrane protein Tmp21 , transmembrane trafficking protein , growth-related translationally controlled tumor protein , growth-related translationally-controlled tumor protein , translationally-controlled tumor protein homolog

GENE ID SPEZIES
373685 Xenopus laevis
436788 Danio rerio
491154 Canis lupus familiaris
714274 Macaca mulatta
747897 Pan troglodytes
100113467 Sus scrofa
8851 Homo sapiens
12569 Mus musculus
116671 Rattus norvegicus
282173 Bos taurus
361568 Rattus norvegicus
532569 Bos taurus
68581 Mus musculus
396363 Gallus gallus
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