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Expression of E-cadherin was significantly associated with the diffuse-type familial EOGCs and early stage, whereas expression of ERalpha (zeige ESR1 Proteine) might have little role in EOGC tumorigenesis.
Loss of TET1 (zeige TET1 Proteine) expression facilitates colon cancer cell migration via H3K27me3-mediated repression of E-cadherin expression.
Immunostaining revealed that NKA (zeige TAC1 Proteine) was co-localized with E-cadherin in the glands of the gastric epithelium. Both NKA (zeige TAC1 Proteine) activity and alpha1-isoform protein expression were reduced in the study group (P < 0.05), indicating impaired NKA (zeige TAC1 Proteine) functions
The expression of E-cad and VEGF and their relationship with clinical features of triple-negative breast cancer (TNBC) suggest that Uygur patients might have different prognostic factors as compared with Han patients. The expression of E-cad was negatively correlated with lymph node metastasis, stage, and histological grade.
CDH1 single-nucleotide polymorphisms role in susceptibility to non-small cell lung cancer
ZIP6 (zeige SLC39A6 Proteine) deficiency disturbs intracellular Zn2+ homeostasis, leading to increased cell survival in hypoxia and reduced E-cadherin expression, indicating that decreased ZIP6 (zeige SLC39A6 Proteine) expression is strongly associated with resistance to hypoxia.
Results show that mesenchymal N-cadherin (zeige CDH2 Proteine)-expressing (Ncad (zeige CDH2 Proteine)+) cells and MCAs invade much more efficiently than E-cadherin-expressing (Ecad+) cells. Data emphasize the role of Ncad (zeige CDH2 Proteine) in intraperitoneal seeding of EOC and provide the rationale for future studies targeting Ncad (zeige CDH2 Proteine) in preclinical models of epithelial ovarian cancer metastasis.
Study demonstrated that down-regulation of E-cadherin contributes to epithelial-to-mesenchymal transition-mediated chemo-resistance of prostate cancer.
Results suggest that epigenetic aberration of the e-cadherin gene (CDH1) may occur in the endometrium of patients with fibroids, which may be associated with E-cadherin protein expression in endometrial tissue.
E-cadherin genetic variants control disease severity and progression and could be a marker of disease outcome.
In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin (zeige CDH2 Proteine) is required for lens fiber growth
These data indicate that emi1 (zeige FBXO5 Proteine) deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 molecular axis.
without Chp (zeige CHP Proteine) signaling, E-cadh shifts to intracellular vesicles rather than the adhesive contacts needed for directed cell movement during epiboly
Downregulation of E-cadherin gene may cause omphalocele in the Cd chick model by disrupting CRT (zeige CALR Proteine)-mediated Ca(2 (zeige CA2 Proteine)+) signaling and AJs.
analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system
cadherin-1 is detected in the epidermis of the embryonic limb buds and the larval pectoral fins of zebrafish
hab/E-cadherin is necessary for the cell rearrangements that spread the teleost blastoderm over the yolk
Lgl2 (zeige LLGL2 Proteine) and E-cadherin act antagonistically to control the localisation of integrin alpha 6 (zeige ITGA6 Proteine) during the formation of hemidesmosomes in the developing epidermis
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
cadherin-mediated cell adhesion between the deep cells and enveloping layerplays a role in the epiboly movement in zebrafish
E-cadherin mRNA/protein were up-regulated in all flutamide-treated corpus luteum of mid- and late pregnancy.
In pig kidney, strong E-cadherin expression was observed in the basolateral plasma membrane of the tubular epithelial cells. E-cadherin immunolabeling was not detected in glomeruli or blood vessels of pig kidney.
Localisation of NANOG (zeige NANOG Proteine), OCT4 (zeige POU5F1 Proteine), and E-CADHERIN in porcine pre- and peri (zeige PLIN1 Proteine)-implantation embryos.
The epiblast expressed epithelial markers, MUC1 (zeige MUC1 Proteine) and E-CADHERIN, and the pluripotency markers, DNMT3B (zeige DNMT3B Proteine) and CRIPTO (zeige TDGF1 Proteine).
E-cadherin has a role in cranial neural crest migration in Xenopus laevis
the switch from E- to N-cadherin (zeige CDH2 Proteine) during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.
Moderate attenuation of C-cadherin function affects cell adhesion but not gastrulation.
Because paraxial protocadherin and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.
The functional and physical relationships between PAPC, FLRT3, and C-cadherin, was investigated.
PAPC mediates these functions by down-regulating the adhesion activity of C-cadherin.
Results suggest that the basis for cell segregation during morphogenesis does not map exclusively to protein-level differences in E-, N-, or C-cadherin adhesion.
G-protein-coupled receptors control cortical actin assembly by controlling the amount of cadherin expressed on the cell surface.
Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region
Data show that the intracellular domain of PAPC (Protocadherin) interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.
PTEN loss in E-cadherin-deficient mouse mammary epithelial cells rescues apoptosis and results in development of classical invasive lobular carcinoma.
Low CDH1 expression is associated with Gastric Tumorigenesis.
These observations highlight the relevance of APC (zeige APC Proteine)/C cofactor Cdh1 activity during G1 to ensure an adequate supply of deoxynucleoside triphosphates to the replisome, prevent replication stress and the resulting chromosomal breaks and, ultimately, suppress tumorigenesis.
Ilk (zeige ILK Proteine) and ELMO2 (zeige ELMO2 Proteine) modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin-based adherens junctions.
JNK (zeige MAPK8 Proteine) signaling, which is inversely correlated with WNT4 (zeige WNT4 Proteine), plays an important role in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin junctions between oocytes in mouse ovaries.
The expression level of E-cadherin protein was significantly decreased in fibrotic livers.
We conclude that p120ctn (zeige CTNND1 Proteine) is not only an adaptor and regulator of E-cadherin, but is also indispensable for proper lineage commitment.
The reduction in tumor growth in fat1 mice compared with wildtype controls may have been associated, in part, to the: i) Increased expression of Ecadherin and the reduced expression of its transcriptional repressors.
These observations suggest that the overexpression of CatE (zeige CTSE Proteine) interferes with neuronal differentiation of P19 (zeige CDKN2D Proteine) cells through an impairment of cell aggregate formation, possibly through proteolytic degradation of N-cadherin (zeige CDH2 Proteine).
E-cadherin-mediated cell-cell contacts can modulate osteoclast-specific gene expression and prompt differentiating osteoclast precursors toward migratory and fusion activities.
Transfection of zygotes with 100 and 200 nM E-cadherin siRNA led to a 72 and 38% reduction, respectively, in E-cadherin mRNA relative abundance in Day 7 blastocysts compared with controls.
E-cadherin and beta-catenin (zeige CTNNB1 Proteine) were distributed not only at the cell to cell boundary but throughout the cytoplasm in binucleate trophoblast cells
Results describe the effect of suppression of connexin 43 (zeige GJA1 Proteine) and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
, cadherin 1, E-cadherin (epithelial)
, calcium-dependent adhesion protein, epithelial
, cell-CAM 120/80
, epithelial cadherin
, hypothetical protein LOC368517
, cadherin 1, epithelial
, half baked
, hypothetical protein LOC368516
, cadherin 1, type 1, E-cadherin (epithelial)
, C-cadherin (EP-cadherin)
, liver cell adhesion molecule
, liver cell adhesion protein
, Epithelial cadherin