anti-TSC2 (TSC2) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 747 Tuberous Sclerosis 2 (TSC2) Antikörper von 25 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TSC2 Kits (14) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 784 TSC2 Produkte verfügbar.
Synonyme:
fc16b02, LAM, Nafld, Rc, Tcs2, TSC2, TSC4, tuberin, wu:fc16b02
Alle Antikörper anzeigen Gen GeneID UniProt
TSC2 7249 P49815
TSC2 22084  
TSC2 24855 P49816

Meistgesuchte Reaktivitäten zu anti-TSC2 (TSC2) Antikörper

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anti-Mouse (Murine) TSC2 Antikörper:

anti-Rat (Rattus) TSC2 Antikörper:

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Weitere Antikörper gegen TSC2 Interaktionspartner

Zebrafish Tuberous Sclerosis 2 (TSC2) Interaktionspartner

  1. This is the first report using an animal model to show interactions between tsc2, mTORC1 and p53 (zeige TP53 Antikörper) during tumorigenesis.

  2. These results demonstrate a highly conserved role of tsc2 in zebrafish and establish a new animal model for studies of Tuberous sclerosis complex.

Human Tuberous Sclerosis 2 (TSC2) Interaktionspartner

  1. Novel missense mutation in the exon 19 of the TSC2 gene is associated with tuberous sclerosis.

  2. our findings suggest the significance of previously undocumented mutation-dependent mTOR (zeige FRAP1 Antikörper) hyperactivation and frequent TSC1 (zeige TSC1 Antikörper)/2 mutations in HBV-associated HCCs (zeige HCCS Antikörper). They define a molecular subset of HCC (zeige FAM126A Antikörper) having genetic aberrations in mTOR (zeige FRAP1 Antikörper) signalling, with potential significance of effective specific drug therapy.

  3. Mutation in TSC2 is associated with lymphangioleiomyomatosis.

  4. Results show that tuberous sclerosis complex disease segregates with a silent substitution in TSC2, c.4149C>T, p.(Ser1838Ser), which leads to the formation of an active donor splice site, resulting in three shorter alternatively spliced transcripts with premature stop codons.

  5. Clinical whole exome sequencing of blood and tumor samples con (zeige DISP1 Antikörper) fi rmed the diagnosis of methylmalonic acidemia and revealed two somatic inactivating mutations in TSC2, suggesting the potential consideration of an mTOR (zeige FRAP1 Antikörper) inhibitor in the event of tumor recurrence.

  6. TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.

  7. The mTOR (zeige FRAP1 Antikörper)-dependent, epithelial phenotype of TSC (zeige SLC12A3 Antikörper) astrocytes suggests TSC1 (zeige TSC1 Antikörper)/2 and mTOR (zeige FRAP1 Antikörper) tune the phosphorylation level of catenin delta-1 (zeige CTNND1 Antikörper) by controlling PKCe (zeige PRKCE Antikörper) activity, thereby regulating the mesenchymal-epithelial-transition (MET)

  8. TSC2 mutations leading to severe tuberous sclerosis in Chinese children.

  9. Our results indicate that TSC2 and less commonly TSC1 (zeige TSC1 Antikörper) alterations are the primary essential driver event in angiomyolipoma/Lymphangioleiomyomatosis, whereas other somatic mutations are rare and likely do not contribute to tumor development.

  10. These results suggested that TSC2 heterozygosity caused neurological malformations in primitive neural stem cells, indicating that its heterozygosity might be sufficient for the development of neurological abnormalities in patients.

Mouse (Murine) Tuberous Sclerosis 2 (TSC2) Interaktionspartner

  1. Tsc2-mTOR (zeige FRAP1 Antikörper) signaling in mesenchyme is essential for the maintenance of renal structure and for lung alveolarization.

  2. TSC1 (zeige TSC1 Antikörper)/TSC2 complex upregulation of OPN (zeige SPP1 Antikörper) expression is mediated by transcription factor SOX9 (zeige SOX9 Antikörper) in an mTOR (zeige FRAP1 Antikörper)-independent manner. Moreover, ablation of OPN (zeige SPP1 Antikörper) by deficient TSC1 (zeige TSC1 Antikörper)/TSC2 complex contributed to inactivation of AKT (zeige AKT1 Antikörper) in TSC (zeige SLC12A3 Antikörper) cells

  3. Rheb (zeige RHEB Antikörper) and TSC2 have roles in the mechanical activation of mTOR (zeige FRAP1 Antikörper) signaling

  4. this study shows that TSC2 maintains macrophage quiescence and prevents mTORC1-dependent granulomatous disease with clinical implications for sarcoidosis

  5. TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.

  6. Repression of TSC1 (zeige TSC1 PLURAL_@4252@)/TSC2 mediated by MeCP2 (zeige MECP2 PLURAL_@4252@) regulates human embryo lung fibroblast cell differentiation and proliferation.

  7. Formation of ROS (zeige ROS1 Antikörper) and activity of NADPH (zeige FDXR Antikörper) oxidases were significantly higher in mouse embryonic fibroblasts and in primary culture of rat renal proximal tubular epithelial tuberin-deficient cells compared to wild-type cells.

  8. Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 (zeige HDAC1 Antikörper) and HdAC2 (zeige HDAC2 Antikörper), tuberous sclerosis complex 2 (TSC2), and mTOR (zeige FRAP1 Antikörper) srine-threonine kinases (mTOR (zeige FRAP1 Antikörper)).

  9. autophagy via the TSC2-mTORC1 signaling pathway plays an important role in maintenance of cardiac function and mitochondrial quantity and size in the heart.

  10. PAK2 (zeige PAK2 Antikörper) is a direct effector of TSC1 (zeige TSC1 Antikörper)-TSC2-RHEB (zeige RHEB Antikörper) signaling and a new target for rational drug therapy in TSC (zeige SLC12A3 Antikörper).

Pig (Porcine) Tuberous Sclerosis 2 (TSC2) Interaktionspartner

  1. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (zeige PRKAA1 Antikörper)/ERK (zeige MAPK1 Antikörper)/TSC2/mTOR (zeige FRAP1 Antikörper) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

Cow (Bovine) Tuberous Sclerosis 2 (TSC2) Interaktionspartner

  1. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (zeige FRAP1 Antikörper) and ribosomal protein S6 (zeige RPS6 Antikörper) kinase (zeige RPS6KB1 Antikörper) signaling in an AKT (zeige AKT1 Antikörper)-independent manner

TSC2 Antigen-Profil

Beschreibung des Gens

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with TSC2

  • tuberous sclerosis 2 (TSC2) Antikörper
  • tuberous sclerosis complex 2 (TSC2) (AaeL_AAEL007712) Antikörper
  • tuberous sclerosis 2 (tsc2) Antikörper
  • tuberous sclerosis 2 (PGTG_00159) Antikörper
  • tuberous sclerosis 2 (Tsc2) Antikörper
  • fc16b02 Antikörper
  • LAM Antikörper
  • Nafld Antikörper
  • Rc Antikörper
  • Tcs2 Antikörper
  • TSC2 Antikörper
  • TSC4 Antikörper
  • tuberin Antikörper
  • wu:fc16b02 Antikörper

Bezeichner auf Proteinebene für TSC2

tuberous sclerosis complex 2 (TSC2) , tuberous sclerosis 2 , tuberin-like , tuberin , tuberous sclerosis 2 protein , tuberous sclerosis 2 protein homolog , renal carcinoma , tuberous sclerosis 2 homolog protein

GENE ID SPEZIES
100065679 Equus caballus
5569538 Aedes aegypti
468086 Pan troglodytes
567524 Danio rerio
694965 Macaca mulatta
10528144 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100170546 Xenopus (Silurana) tropicalis
100390664 Callithrix jacchus
7249 Homo sapiens
22084 Mus musculus
24855 Rattus norvegicus
479883 Canis lupus familiaris
100505408 Sus scrofa
504985 Bos taurus
416552 Gallus gallus
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