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anti-Mouse (Murine) DDR1 Antikörper:
anti-Human DDR1 Antikörper:
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Human Monoclonal DDR1 Primary Antibody für ELISA, WB - ABIN965982
Foehr, Tatavos, Tanabe, Raffioni, Goetz, Dimarco, De Luca, Bradshaw: Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000
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Human Monoclonal DDR1 Primary Antibody für ELISA, WB - ABIN969082
Mohan, Mohan, Wilson: Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea. in Experimental eye research 2001
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Human Polyclonal DDR1 Primary Antibody für IHC, ELISA - ABIN1847697
Xu, Abe, Liu, Zalivina, Hohenester, Leitinger: Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications. in The Journal of biological chemistry 2014
Human Polyclonal DDR1 Primary Antibody für ELISA, WB - ABIN560139
Turashvili, Bouchal, Baumforth, Wei, Dziechciarkova, Ehrmann, Klein, Fridman, Skarda, Srovnal, Hajduch, Murray, Kolar: Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. in BMC cancer 2007
Human Polyclonal DDR1 Primary Antibody für IHC (p) - ABIN2478753
Coakley, Hawkins, Crinis, McManus, Blake, Nordmann, Sloan, Connelly: An unusual case of variegate porphyria with possible homozygous inheritance. in Australian and New Zealand journal of medicine 1990
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DDR-1 interacts with the TGF-beta (zeige TGFB1 Antikörper) pathway to restrict calcifying extracellular vesicle-mediated mineralization and fibrosis by smooth muscle cells.
alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor (zeige ITGA2 Antikörper) DDR1-mediated ERK (zeige EPHB2 Antikörper) activation.
DDR1 malfunction causes outer hair cells deformation and the separation of the lateral wall, the location of the cellular motor responsible for the electromotile property, explicitly in those regions showing DDR1 and NM-IIA co-localization.
the collagen receptors DDR1 and integrin a2b1 contribute to regulate GBM-maturation and to control matrix accumulation.
Extensive co-localization and relationship of Jag1 (zeige JAG1 Antikörper) and Ddr1 in bile ducts and blood vessels in postnatal liver.
Genetic inhibition of discoidin domain receptor 1 protects mice against crescentic glomerulonephritis.
Data identifyies Syk (zeige SYK Antikörper) as a potent inhibitor of epithelial migration and describes a first functional consequence of the interaction with the collagen receptor (zeige ITGA2 Antikörper) DDR1.
Results show that DDR1 promotes cell-cell adhesion and differentiation through stabilization of E-cadherin (zeige CDH1 Antikörper), which is mediated by Cdc42 (zeige CDC42 Antikörper) inactivation.
Collagen I stimulates the self-renewal of embryonic stem cells mediated by Bmi-1 (zeige BMI1 Antikörper) through alpha2beta1 integrin-dependent ILK (zeige ILK Antikörper), Notch (zeige NOTCH1 Antikörper), Gli-1 (zeige GLI1 Antikörper), and DDR1-dependent Ras, PI3K/Akt (zeige AKT1 Antikörper), and ERK (zeige EPHB2 Antikörper).
Loss of Discoidin domain receptor 1 is associated with inflammation and fibrosis in obstructive nephropathy
DDR1 activation markedly amplifies TNF-alpha (zeige TNF Antikörper)- and LPS (zeige IRF6 Antikörper)-induced phenotypic and functional maturation of dendritic cells (DCs) through activation of p38 mitogen-activated protein kinase (zeige MAPK14 Antikörper).
DDR1 contributes to fibroblast survival in the tissue microenvironment of idiopathic pulmonary fibrosis and its up-regulation may occur in other fibroproliferative lung diseases as well.
we further analyzed the CpG methylation levels at the DDR1 promoter in EOC cells and found that the CpG methylation levels of DDR1 promoter correlated negatively with the expression of DDR1 along the EMT (zeige ITK Antikörper) spectrum. Therefore, EMT (zeige ITK Antikörper) stratification could be a potential biomarker to predict patient response to DDR1-targeting drugs.
This study suggested that DDR1 and DDR2 (zeige DDR2 Antikörper) knockdown alters brain immunity and significantly reduces the level of triggering receptor expressed on myeloid cells (TREM)-2 (zeige TREM2 Antikörper) and microglia.
Isoform b of DDR1 is responsible for collagen I-induced up-regulation of N-cadherin (zeige CDH2 Antikörper) and tyrosine 513 of DDR1b is necessary.
Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo (zeige MITF Antikörper) pathogenesis
data demonstrate that TGF-beta1 (zeige TGFB1 Antikörper) favors linear invadosome formation through the expressions of both the inducers, such as collagen and LOXL2 (zeige LOXL2 Antikörper), and the components such as DDR1 and MT1-MMP (zeige MMP14 Antikörper) of linear invadosomes in cancer cells. Meanwhile, our data uncover a new TGF-beta1 (zeige TGFB1 Antikörper)-dependent regulation of DDR1 expression.
DDR1 overexpression promoted GC cell proliferation (p < 0.05), migration (p < 0.01), and invasion (p < 0.01), and accelerated the growth (p < 0.05) as well as the microvessel formation (p < 0.01) of transplantation tumor in nude mice.
Our results suggest that DDR1 is both a prognostic marker for renal clear cell carcinoma and a potential functional target for therapy
Study concludes that non-canonical DDR1 signaling enables breast cancer cells to exploit the ubiquitous interstitial matrix component collagen I to undergo metastatic reactivation in multiple target organs.
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, discoidin domain receptor
, CD167 antigen-like family member A
, cell adhesion kinase
, discoidin receptor tyrosine kinase
, epithelial discoidin domain receptor 1
, epithelial discoidin domain-containing receptor 1
, protein-tyrosine kinase MPK-6
, tyrosine kinase DDR
, tyrosine-protein kinase CAK
, PTK3A protein tyrosine kinase 3A
, mammary carcinoma kinase 10
, neuroepithelial tyrosine kinase
, neurotrophic tyrosine kinase, receptor, type 4
, protein-tyrosine kinase RTK-6
, discoidin domain receptor family, member 1
, neurotrophic tyrosine kinase receptor type 4
, protein-tyrosine kinase 3
, protein-tyrosine kinase PTK-3