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anti-Human SRSF1 Antikörper:
anti-Mouse (Murine) SRSF1 Antikörper:
anti-Rat (Rattus) SRSF1 Antikörper:
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Human Polyclonal SRSF1 Primary Antibody für ICC, IF - ABIN4353084
Brown, Dobrikov, Gromeier et al.: Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated ... in Journal of virology 2014
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Cow (Bovine) Polyclonal SRSF1 Primary Antibody für IHC, WB - ABIN2779013
Velazquez-Dones, Hagopian, Ma, Zhong, Zhou, Ghosh, Fu, Adams: Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. in The Journal of biological chemistry 2005
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DLP (zeige DMD Antikörper) and ASF1 are part of a predeposition complex, which is recruited by XNP (zeige ATRX Antikörper) and is necessary to prevent DNA exposure in the nucleus.
ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a (zeige ASF1A Antikörper) by TLK (zeige TLK2 Antikörper) kinases.
dASF1 has a direct role in modifying chromatin structure during DNA replication and this function of dASF1 is important for the processivity of the replication machinery.
Asf1 is directed via interactions with sequence-specific complexes to mediate silencing of specific target genes.
Histone chaperones ASF1 and NAP1 (zeige NAP1L1 Antikörper) differentially modulate removal of active histone marks by LID-RPD3 (zeige HDAC1 Antikörper) complexes during NOTCH (zeige NOTCH1 Antikörper) silencing.
high level of SF2, as a novel oncoprotein in RCC (zeige XRCC1 Antikörper), was significantly associated with poor survival in a large cohort of RCC (zeige XRCC1 Antikörper) specimens. Taken together, our study presents a road map for the prediction and validation of miR (zeige MLXIP Antikörper)-766-3p/SF2 axis and thus imparts a therapeutic way for further RCC (zeige XRCC1 Antikörper) progression.
The authors found that RNA recognition motif 1 (RRM1 (zeige RRM1 Antikörper)) in SRSF1 binds PP1 (zeige PPA1 Antikörper) and represses its catalytic function through an allosteric mechanism.
We present a joint atomistic molecular dynamics (MD) and experimental study of two RRM-containing proteins bound with their single-stranded target RNAs, namely the Fox-1 (zeige A2BP1 Antikörper) and SRSF1 complexes.The simulations predict unanticipated specific participation of Arg142 at the protein-RNA interface of the SRFS1 complex, which is subsequently confirmed by NMR and ITC measurements
Using NMR spectroscopy with two separately expressed domains of SRSF1, we showed that several residues in the RNA-binding motif 2 interact with the N-terminal region of the RS domain (RS1 (zeige RS1 Antikörper)).
Especially, in SRSF1 morphants, bone cartilage formation was reduced in the brain and Nkx-2.5 (zeige NKX2-5 Antikörper) expression was dramatically reduced in the heart of SRSF1 morphants. In addition, a dramatic reduction in functional chordin (zeige CHRD Antikörper) RNA in SRSF1 morphants was observed suggesting that chordin (zeige CHRD Antikörper) is one of the targets of SRSF1. Thus, we concluded that SRSF1 is an essential factor for pattern formation including heart, cartilage and germ lay
results strongly support SRSF1 as a prognostic biomarker in SCLC and provide a rationale for personalized therapy in SCLC
NSrp70 (zeige NSRP1 Antikörper) acts as a new molecular counterpart for alternative splicing of target RNA, counteracting SRSF1 and SRSF2 (zeige SRSF2 Antikörper) splicing activity.
we have identified for the first time a potential mechanism that involves the essential splicing factor (zeige SLU7 Antikörper) ASF/SF2 through which morphine regulates splicing specificity of the MOR (zeige OPRM1 Antikörper) encoding gene, OPRM1 (zeige OPRM1 Antikörper).
Global splicing analysis with RNA-seq revealed that exons carrying the hnRNP H (zeige HNRNPH1 Antikörper)-binding GGGGG motif are predisposed to be skipped compared to those carrying the SRSF1-binding GGAGG motif in both human and mouse brains.
We present experimental evidence that splicing factor (zeige SLU7 Antikörper) SRSF1, SRSF2 (zeige SRSF2 Antikörper), U2AF35 (zeige U2AF1 Antikörper), U2AF65 (zeige U2AF59 Antikörper) and KHSRP (zeige KHSRP Antikörper) expression levels in gastrointestinal tract (colon, gastric and pancreatic) tumors differ compare to healthy tissues and in cell lines
The expression levels of three splicing factors, ESRP1 (zeige ESRP1 Antikörper), PTB (zeige PTBP1 Antikörper) and SF2/ASF, are significantly altered during cardiac hypertrophy in mice.
RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1
Deletion of RRM1 (zeige RRM1 Antikörper) eliminated the splicing activity of SRSF1 and thus cellular transformation.
Specific effects on regulated splicing by SR proteins SRSF1 and SRSF2 (zeige SRSF2 Antikörper) depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.
Treatment with IL-17 (zeige IL17A Antikörper) prolongs the half-life of chemokine (zeige CCL1 Antikörper) CXCL1 (zeige CXCL1 Antikörper) mRNA via the adaptor TRAF5 (zeige TRAF5 Antikörper) and the splicing-regulatory factor SF2 (ASF).
analysis of the miRNA-mediated interaction between leukemia/lymphoma-related factor (LRF (zeige ZBTB7A Antikörper)) and alternative splicing factor/splicing factor (zeige SLU7 Antikörper) 2 (ASF/SF2) affects cell senescence and apoptosis
Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 (zeige SMN1 Antikörper) causes spinal muscular atrophy in the absence of SMN1 (zeige SMN1 Antikörper)
Both hnRNP A1 (zeige HNRNPA1 Antikörper) and alternative splicing factor/splicing factor (zeige SLU7 Antikörper) 2 contents rose in adenomas and during injury-induced hyperplasia compared to control lungs
These results highlight the requirement of Sfrs1-mediated alternative splicing for the survival of retinal neurons, with sensitivity defined by the window of time in which the neuron was generated.
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13.
, anti- silencing function 1
, anti-silencing factor
, splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)
, SR splicing factor 1
, alternative-splicing factor 1
, pre-mRNA-splicing factor SF2, P33 subunit
, splicing factor 2
, splicing factor, arginine/serine-rich 1
, splicing factor arginine/serine-rich 1
, splicing factor, arginine/serine-rich 1B
, pre-mRNA-splicing factor SRp30a
, splicing factor, arginine/serine-rich 1 (ASF/SF2)
, serine/arginine-rich splicing factor 1B
, splicing factor, arginine/serine-rich 1b