Tropomyosin 1 (Alpha) Proteine (TPM1)

Tropomyosin 1 (Alpha) Proteine (TPM1)
Auf finden Sie aktuell 41 Tropomyosin 1 (Alpha) (TPM1) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Tropomyosin 1 (Alpha) Antikörper (88) und Tropomyosin 1 (Alpha) Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 139 Tropomyosin 1 (Alpha) Produkte verfügbar.
AA986836, AI854628, alpha-fTM, alpha-tm, alpha-tropomyosin, C15orf13, CH1, CMD1Y, CMH3, fb37a09, HTM-alpha, MGC84844, tm, TM2, Tm3, Tm7, Tma2, Tmpa, TMSA, Tpm-1, TPM1, TPMA, wu:fb37a09
alle Proteine anzeigen Gen GeneID UniProt
TPM1 22003 P58771
TPM1 24851 P04692
TPM1 7168 P09493

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Am meisten referenzierte Tropomyosin 1 (Alpha) Proteine

  1. Human TPM1 Protein expressed in Escherichia coli (E. coli) - ABIN667191 : Perry: Vertebrate tropomyosin: distribution, properties and function. in Journal of muscle research and cell motility 2001 (PubMed)
    Zeige alle 2 Referenzen für 667191

Weitere Proteine zu Tropomyosin 1 (Alpha) Interaktionspartnern

Cow (Bovine) Tropomyosin 1 (Alpha) (TPM1) Interaktionspartner

  1. The tendency of smooth muscle tropomyosin to form semi-rigid polymers with continuous and undampened rigidity may compensate for the lack of troponin-based structural support in smooth muscles.

  2. Deletion of regions 2-3 in tropomyosin (zeige TPM2 Proteine) alpha resulted in an 60 % decrease in both isometric tension and stiffness of tropomyosin (zeige TPM2 Proteine)-reconstituted myocardium.

  3. Tropomyosin (zeige TPM2 Proteine) is primarily responsible for the change in the kinetic constants of the elementary steps of the cross bridge cycle.

  4. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules

Mouse (Murine) Tropomyosin 1 (Alpha) (TPM1) Interaktionspartner

  1. Stress fibre formation and up-regulation of alpha-smooth muscle actin (zeige ACTG2 Proteine) (alphaSMA (zeige ACTA2 Proteine)) induced by TGFbeta2 could be reversed by Tpm1/2 knock-down by siRNA.

  2. The cMyBP-C hypertrophic cardiomyopathy variant L348P enhances thin filament activation through an increased shift in tropomyosin (zeige TPM2 Proteine) position.

  3. three-dimensional structure of F-actin at a resolution of 3.7 A in complex with tropomyosin (zeige TPM2 Proteine) at a resolution of 6.5 A, determined by electron cryomicroscopy

  4. data also identify a novel alphaTM1/Tmod1-based pathway stabilizing F-actin at cell-cell junctions, which may be required for maintenance of cell shapes during embryonic cardiac morphogenesis.

  5. This is the first study to demonstrate that decreasing phosphorylation of tropomyosin (zeige TPM2 Proteine) can rescue a hypertrophic cardiomyopathic phenotype.

  6. Tropomyosin (zeige TPM2 Proteine) dephosphorylation results in myocyte hypertrophy with increases in SERCA2a (zeige ATP2A2 Proteine) expression.

  7. The results identify a novel mode of myofilament desensitization to Ca(2 (zeige CA2 Proteine)+) associated with a DCM linked switch in TPM1-kappa.

  8. signaling by alpha-tropomyosin may have a role in familial hypertrophic cardiomyopathy

  9. A point mutation in alpha-TM causes a disease similar to familial hypertophic cardiomyopahy.

  10. PTB (zeige PTBP1 Proteine) interacting protein raver1 (zeige RAVER1 Proteine) regulates alpha-tropomyosin alternative splicing.

Human Tropomyosin 1 (Alpha) (TPM1) Interaktionspartner

  1. Stress fibre formation and up-regulation of alpha-smooth muscle actin (zeige ACTG2 Proteine) (alphaSMA (zeige ACTA2 Proteine)) induced by TGFbeta2 could be reversed by Tpm1/2 knock-down by siRNA.

  2. data demonstrate that the K15N mutation alters pointed end dynamics by affecting molecular interactions between Tpm1.1, Lmod2 (zeige LMOD2 Proteine) and Tmod1 (zeige TMOD1 Proteine).

  3. Results report evidence for the existence of variants in LHFPL2 (zeige LHFPL2 Proteine) and TPM1 with low allele frequencies and large effects on age-at-onset of familial Parkinson's disease.

  4. In diabetes, expression of high molecular weight (HMW) isoforms from tropomyosin 1 (TPM1) were markedly decreased but HMW isoforms from tropomyosin 4 (TPM4 (zeige TPM4 Proteine)) were not significantly different.

  5. results suggest that TPM1 can suppress tumors in oral squamous cell carcinoma, and the TPM1 expression level is related to oral squamous cell carcinoma patient prognosis

  6. Data suggest that the tropomyosin (zeige TPM2 Proteine) overlap region structure and function are affected differentially by a point mutation in cardiac tropomyosin (TPM1, D230N) that is associated with dilated cardiomyopathy as compared to a point mutation in cardiac troponin T (TNNT2 (zeige TNNT2 Proteine), R92L) that is associated with hypertrophic cardiomyopathy.

  7. Data indicate that various hypertrophic cardiomyopathy (HCM) mutations can differently affect the structural and functional properties of tropomyosin (zeige TPM2 Proteine) (Tpm (zeige TPMT Proteine)) and cause HCM by different molecular mechanisms.

  8. Promoter variants in HOXA9 (zeige HOXA9 Proteine), TPM1, and TPM2 (zeige TPM2 Proteine), alter promoter expression suggesting that they have a functional role in clubfoot.

  9. The TPM1 mutations D175N and E180G increased the sliding velocity and its calcium sensitivity of the actin-myosin Interaction, while mutation E40K reduced both these parameters.

  10. No association was observed between the remaining three markers (rs11071720, rs3803499, and rs12148828) and NSOC as well as its subgroups. TPM1 polymorphisms might contribute to the etiology ofnonsyndromic orofacial clefts (NSOC), , and more emphasis should be placed on TPM1 during craniofacial development

Pig (Porcine) Tropomyosin 1 (Alpha) (TPM1) Interaktionspartner

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Rabbit Tropomyosin 1 (Alpha) (TPM1) Interaktionspartner

  1. The results indicate that cross-linking significantly affects properties of Tpm (zeige TPMT Proteine) and actin-myosin interaction and can explain, at least partly, the role of the interchain disulfide cross-linking of cardiac Tpm (zeige TPMT Proteine) in human heart diseases.

  2. altered TM-actin contacts destabilized the thin filament and affected the actin-myosin interactions

  3. analysis of the thin filament associated with the R167H and K168E substitutions in tropomyosin (zeige TPM2 Proteine) Tpm1.1

  4. We propose that TR100 acts to compromise the integrity of Tpm cables rather than prevent overlap complex formation. Our data suggests that TR100 is incorporated into the growing actin-Tpm co-polymer given that its effects cannot be observed on pre-formed Tpm3.1/actin filaments

  5. Maximal Ca(2 (zeige CA2 Proteine)+) activated force was the same in alphaalphaTm versus betabetaTm myofibrils, but betabetaTm myofibrils showed a marked slowing of relaxation and an impairment of regulation under resting conditions

  6. Tmod1 (zeige TMOD1 Proteine) and Tmod3 (zeige TMOD3 Proteine) showed somewhat different tropomyosin (zeige TPM2 Proteine)-binding site utilization.

  7. Thermal denaturation of rabbit cardiac alpha,alpha-tropomyosin is monitored at neutral pH and compared to shark tropomyosin (zeige TPM2 Proteine), showing that amino acid substitutions predicted to be unfavorable in one temperature regime are desirable in another.

  8. The rotational motion of a spin label covalently bound to the side chain of a cysteine genetically incorporated into rabbit skeletal muscle tropomyosin (zeige TPM2 Proteine), was measured.

  9. a computational search assessing electrostatic interactions for multiple azimuthal locations, z-positions, and pseudo-rotations of tropomyosin on F-actin was performed.

Tropomyosin 1 (Alpha) (TPM1) Protein Überblick

Protein Überblick

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

Alternative names and synonyms associated with Tropomyosin 1 (Alpha) (TPM1)

  • tropomyosin 1 (alpha) (TPM1)
  • tropomyosin (LOC100101174)
  • tropomyosin (tm7)
  • tropomyosin 1, alpha (Tpm1)
  • alpha-tropomyosin (tpma)
  • tropomyosin 1 (alpha) (tpm1)
  • alpha-tropomyosin (LOC100125989)
  • tropomyosin (Smp_044010.2)
  • tropomyosin 1 (LOC732984)
  • AA986836 Protein
  • AI854628 Protein
  • alpha-fTM Protein
  • alpha-tm Protein
  • alpha-tropomyosin Protein
  • C15orf13 Protein
  • CH1 Protein
  • CMD1Y Protein
  • CMH3 Protein
  • fb37a09 Protein
  • HTM-alpha Protein
  • MGC84844 Protein
  • tm Protein
  • TM2 Protein
  • Tm3 Protein
  • Tm7 Protein
  • Tma2 Protein
  • Tmpa Protein
  • TMSA Protein
  • Tpm-1 Protein
  • TPM1 Protein
  • TPMA Protein
  • wu:fb37a09 Protein

Bezeichner auf Proteinebene für Tropomyosin 1 (Alpha) Proteine (TPM1)

alpha-tropomyosin 1 , alpha-tropomyosin 2 , alpha-tropomyosin of skeletal fast muscle , tropomyosin (CTm4) , tropomyosin (CTm7) , tropomyosin alpha-1 chain , tropomyosin-1 , actotropomyosin , tropomyosin-2 , tropomyosin , Tropomyosin-1 alpha chain , tropomyosin 1 alpha chain , alpha tropomyosin , alpha-tropomyosin , hepatoma alpha tropomyosin , smooth muscle alpha-tropomyosin , striated muscle alpha-tropomyosin , tropomyosin 3 alpha , alpha-skeletal tropomyosin , cardiomyopathy, hypertrophic 3 , sarcomeric tropomyosin kappa , tropomyosin 1 (alpha) isoform 1 , tropomyosin 1 (alpha) isoform 2 , tropomyosin 1 (alpha) isoform 3 , tropomyosin 1 (alpha) isoform 4 , tropomyosin 1 (alpha) isoform 5 , tropomyosin 1 (alpha) isoform 6 , tropomyosin 1 (alpha) isoform 7

396366 Gallus gallus
100101174 Bombyx mori
431788 Xenopus laevis
281544 Bos taurus
22003 Mus musculus
24851 Rattus norvegicus
30324 Danio rerio
100189579 Xenopus laevis
7168 Homo sapiens
478332 Canis lupus familiaris
100037999 Sus scrofa
100125989 Oryctolagus cuniculus
8350314 Schistosoma mansoni
732984 Bombyx mori
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