PAIP2 Protein (AA 1-127) (His tag)

Produktnummer ABIN666906

Dieses Recombinant PAIP2-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für PAIP2 Protein (AA 1-127) (His tag) (ABIN666906)

Target: PAIP2 (Poly Binding Protein Interacting Protein 2 (PAIP2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Reinheit: > 90 %

Produktdetails

Proteineigenschaft: AA 1-127

Aufreinigungstag / Konjugat: Dieses PAIP2 Protein ist gelabelt mit His tag.

Sequenz: MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS SLEDLVVKSN LNPNAKEFVP GVKYGNI

Produktmerkmale: PAIP2, 1-127 aa, Human, His-tag, E.coli

Aufreinigung: > 90% by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 20 mM Tris-HCl buffer ( pH 8.0) containing 1 mM DTT, 10 % glycerol

Handhabung: Avoid repeated freezing and thawing cycles

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: PAIP2 (Poly Binding Protein Interacting Protein 2 (PAIP2))

Andere Bezeichnung: PAIP2

Hintergrund: PAIP2, also known as Poly (A) -binding protein-interacting protein 2, acts as a repressor in the regulation of translation initiation of poly (A) -containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. It displaces the interaction of PABPC1 with poly (A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly (A) RNP structure organization. Recombinant PAIP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Molekulargewicht: 17.1 kDa (147aa) confirmed by MALDI-TOF

NCBI Accession: NP_057564