OTUB1 Protein (AA 2-201, partial) (GST tag)
Kurzübersicht für OTUB1 Protein (AA 2-201, partial) (GST tag) (ABIN7479615)
Target
Alle OTUB1 Proteine anzeigenProtein-Typ
Spezies
Quelle
Applikation
Reinheit
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Proteineigenschaft
- AA 2-201, partial
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Aufreinigungstag / Konjugat
- Dieses OTUB1 Protein ist gelabelt mit GST tag.
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Sequenz
- AAEEPQQQKQ EPLGSDSEGV NCLAYDEAIM AQQDRIQQEI AVQNPLVSER LELSVLYKEY AEDDNIYQQK IKDLHKKYSY IRKTRPDGNC FYRAFGFSHL EALLDDSKEL QRFKAVSAKS KEDLVSQGFT EFTIEDFHNT FMDLIEQVEK QTSVADLLAS FNDQSTSDYL VVYLRLLTSG YLQRESKFFE HFIEGGRTVK
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OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) protein (GST tag)
OTUB1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) protein (His-IF2DI Tag)OTUB1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)OTUB1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Buffer
- 6M guanidine hydrochloride, 20mM Tris.
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Lagerung
- 4 °C
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- OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
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Andere Bezeichnung
- Ubiquitin thioesterase OTUB1
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Hintergrund
- Background: Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a nuch lower preference compared to 'Lys-48'-linked ubiquitin. R. Synonyms: Deubiquitinating enzyme OTUB1 OTU domain-containing ubiquitin aldehyde-binding protein 1 Otubain-1 Short name=hOTU1 Ubiquitin-specific-processing protease OTUB1.
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Molekulargewicht
- 50.5 kD
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NCBI Accession
- NM_017670
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UniProt
- Q96FW1
Target
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