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RAD9 has a prominent role in the ATR-Chk1 (zeige CHEK1 Proteine) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.
We demonstrated that Mrad9 null enhances chromatid aberration frequency induced by radiation in bystander mouse embryonic stem cells
RAD9A is essential for male fertility and for repair of DNA double-strand breaks during meiotic prophase I.
HUS1 (zeige HUS1 Proteine) acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 (zeige RAD1 Proteine) and TOPBP1 (zeige TOPBP1 Proteine) respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 or HUS1 (zeige HUS1 Proteine).
A review of the many activities assigned to Rad9, and speculation as to which influence its function in tumor development.
Data show that Rad9 plays dual roles in generating functional antibodies and in maintaining the integrity of the whole genome in B cells.
Rad9A-mediated Claspin localization is a vital step during checkpoint activation.
tousled-like kinases play important roles in DNA repair, not only by modulation of chromatin assembly via Asf1, but also by a more direct function in processing the ends of a tousled-like kinase via interaction with Rad9.
HRAD9 and Mrad9 are part of a gene family and reveal a new genetic element encoding a product that interacts with multiple, known cell cycle checkpoint control proteins.
Results establish mouse rad9 as a key mammalian genetic element of pathways that regulate the cellular response to DNA damage, maintenance of genomic integrity, and proper embryonic development.
TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint
RAD9 has a prominent role in the ATR (zeige ANTXR1 Proteine)-Chk1 (zeige CHEK1 Proteine) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.
these results demonstrate a positive feedback loop involving Rad9A-dependend activation of Chk1 (zeige CHEK1 Proteine).
Intramolecular binding of the rad9 C-terminus in the checkpoint clamp (zeige PDZK1 Proteine) Rad9-Hus1 (zeige HUS1 Proteine)-Rad1 is closely linked with its DNA binding.
The role of Rad9 in homologous recombination is independent of its function in checkpoint activation, and this function is important for preventing alternative non-homologous end joining.
we found that H1299 cells with reduced RAD9 protein levels showed a higher frequency of radiation induced bystander micronuclei formation
These data reveal that human Rad9 interacts directly with N-terminal region of human MYH (zeige MUTYH Proteine).
Downregulation of RAD9 when combined with ionizing radiation results in reduction of ITGB1 (zeige ITGB1 Proteine) protein levels in prostate cancer cells, and increased lethality.
Loss of hrad9 expression is associated with breast and lung cancer.
These data suggest that v-Src (zeige SRC Proteine) attenuates ATR (zeige ANTXR1 Proteine)-Chk1 (zeige CHEK1 Proteine) signaling through the inhibition of Rad17 (zeige RAD17 Proteine)-Rad9 interaction.
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
RAD9 homolog A (S. pombe)
, cell cycle checkpoint control protein RAD9A-like
, RAD9 homolog A
, cell cycle checkpoint control protein RAD9A
, DNA repair exonuclease rad9 homolog A
, Rad9-like protein