PDCD6 Proteine (PDCD6)

Bezeichnung:
Programmed Cell Death 6 Proteine (PDCD6)
Auf www.antikoerper-online.de finden Sie aktuell 16 Programmed Cell Death 6 (PDCD6) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PDCD6 Antikörper (82) und PDCD6 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 105 PDCD6 Produkte verfügbar.
Synonyme:
alg-2, Alg2, AV299538, MA-3, MGC52821, MGC132114, PDCD6, PEF1B, PS2, zgc:63952
alle Proteine anzeigen Gen GeneID UniProt
PDCD6 10016 O75340
PDCD6 18570 P12815
Ratte PDCD6 PDCD6 308061  

Weitere Synonyme anzeigen

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Am meisten referenzierte PDCD6 Proteine

  1. Human PDCD6 Protein expressed in Escherichia coli (E. coli) - ABIN667892 : Suzuki, Kawasaki, Inuzuka, Okumura, Kakiuchi, Shibata, Wakatsuki, Maki: Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism. in Structure (London, England : 1993) 2008 (PubMed)
    Zeige alle 2 Referenzen für 667892

  2. Human PDCD6 Protein expressed in Escherichia coli (E. coli) - ABIN1047560 : Kitaura, Matsumoto, Satoh, Hitomi, Maki: Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner. in The Journal of biological chemistry 2001 (PubMed)
    Zeige alle 2 Referenzen für 1047560

Weitere Proteine zu PDCD6 Interaktionspartnern

Human Programmed Cell Death 6 (PDCD6) Interaktionspartner

  1. The gene copy numbers and mRNA levels for both ALG-2 and HEBP2 (zeige HEBP2 Proteine) are significantly upregulated in breast and lung cancer. Coexpression of ALG-2 and HEBP2 (zeige HEBP2 Proteine) markedly increases the cytoplasmic pool of ALG-2 and alters the subcellular distribution of HEBP2 (zeige HEBP2 Proteine). Abnormalities in the ALG-2/HEBP2 (zeige HEBP2 Proteine) interaction impairs spindle orientation and positioning during mitosis.

  2. The results suggest that ALG-2 acts as a Ca2 (zeige CA2 Proteine)+-sensitive adaptor to concentrate and polymerize TFG at endoplasmic reticulum exit sites, supporting a potential role for ALG-2 in COPII-dependent trafficking from the endoplasmic reticulum.

  3. ALG2 has a tumor suppressive role in glioblastoma and might be a potential target for the treatment of glioblastoma.

  4. miR (zeige MLXIP Proteine)-183 may function as an oncogene (zeige RAB1A Proteine) and may enhance cell proliferation by targeting PDCD6, implying a potential therapeutic target for this malignancy.

  5. Our results suggest that PDCD6 may play an important role in the pathogenesis of cervical squamous cell carcinoma

  6. PDCD6 may represent a biomarker candidate gene that could help to identify a group of patients at high risk for recurrence and death.

  7. Palmitoylation sites and the N-terminal Pro-rich region were necessary for efficient secretion, but ABSs (ALG-2-binding sites) were dispensable.

  8. The present study provided evidence that rs4957014 and rs3756712 are associated with Uterine leiomyoma (UL) risk, the results indicated that genetic polymorphisms in PDCD6 may contribute to the development of UL.

  9. CHERP (zeige CHERP Proteine) and ALG-2 participate in regulation of alternative splicing of IP3R1 (zeige ITPR1 Proteine) pre-mRNA and provide new insights into post-transcriptional regulation of splicing variants in Ca(2 (zeige CA2 Proteine)+) signaling pathways.

  10. the binding of ALG-2 to IST1 (zeige IST1 Proteine) is Ca(2 (zeige CA2 Proteine)+)-dependent

Mouse (Murine) Programmed Cell Death 6 (PDCD6) Interaktionspartner

  1. ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity.

  2. Substitution of either L52 with Ala or F148 with Ser (zeige SIGLEC1 Proteine) of ALG-2 caused loss of binding abilities to PLSCR3 (zeige PLSCR3 Proteine) lacking type 1 motif but retained those to PLSCR3 (zeige PLSCR3 Proteine) lacking type 2 motif

  3. ALG-2 is physiologically dispensable for apoptotic responses (ALG-2 protein)

PDCD6 Protein Überblick

Protein Überblick

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.

Alternative names and synonyms associated with PDCD6

  • programmed cell death 6 (pdcd6)
  • programmed cell death 6 (PDCD6)
  • programmed cell death 6 (Pdcd6)
  • alg-2 Protein
  • Alg2 Protein
  • AV299538 Protein
  • MA-3 Protein
  • MGC52821 Protein
  • MGC132114 Protein
  • PDCD6 Protein
  • PEF1B Protein
  • PS2 Protein
  • zgc:63952 Protein

Bezeichner auf Proteinebene für PDCD6

programmed cell death 6 , programmed cell death protein 6 , apoptosis-linked gene 2 protein , probable calcium-binding protein ALG-2 , ALG-257 , PMP41

GENE ID SPEZIES
380264 Xenopus laevis
393925 Danio rerio
723039 Macaca mulatta
10016 Homo sapiens
18570 Mus musculus
420988 Gallus gallus
609549 Canis lupus familiaris
100125927 Bos taurus
308061 Rattus norvegicus
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