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Human PDCD6 Protein expressed in Escherichia coli (E. coli) - ABIN667892
Suzuki, Kawasaki, Inuzuka, Okumura, Kakiuchi, Shibata, Wakatsuki, Maki: Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism. in Structure (London, England : 1993) 2008
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Human PDCD6 Protein expressed in Escherichia coli (E. coli) - ABIN1047560
Kitaura, Matsumoto, Satoh, Hitomi, Maki: Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner. in The Journal of biological chemistry 2001
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The results suggest that ALG-2 acts as a Ca2 (zeige CA2 Proteine)+-sensitive adaptor to concentrate and polymerize TFG at endoplasmic reticulum exit sites, supporting a potential role for ALG-2 in COPII-dependent trafficking from the endoplasmic reticulum.
ALG2 has a tumor suppressive role in glioblastoma and might be a potential target for the treatment of glioblastoma.
miR (zeige MLXIP Proteine)-183 may function as an oncogene (zeige RAB1A Proteine) and may enhance cell proliferation by targeting PDCD6, implying a potential therapeutic target for this malignancy.
Our results suggest that PDCD6 may play an important role in the pathogenesis of cervical squamous cell carcinoma
PDCD6 may represent a biomarker candidate gene that could help to identify a group of patients at high risk for recurrence and death.
Palmitoylation sites and the N-terminal Pro-rich region were necessary for efficient secretion, but ABSs (ALG-2-binding sites) were dispensable.
The present study provided evidence that rs4957014 and rs3756712 are associated with Uterine leiomyoma (UL) risk, the results indicated that genetic polymorphisms in PDCD6 may contribute to the development of UL.
CHERP (zeige CHERP Proteine) and ALG-2 participate in regulation of alternative splicing of IP3R1 (zeige ITPR1 Proteine) pre-mRNA and provide new insights into post-transcriptional regulation of splicing variants in Ca(2 (zeige CA2 Proteine)+) signaling pathways.
the binding of ALG-2 to IST1 (zeige IST1 Proteine) is Ca(2 (zeige CA2 Proteine)+)-dependent
the current study indicates that PDCD6 gene may be a new susceptibility gene to endometriosis.
ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity.
Substitution of either L52 with Ala or F148 with Ser (zeige SIGLEC1 Proteine) of ALG-2 caused loss of binding abilities to PLSCR3 (zeige PLSCR3 Proteine) lacking type 1 motif but retained those to PLSCR3 (zeige PLSCR3 Proteine) lacking type 2 motif
ALG-2 is physiologically dispensable for apoptotic responses (ALG-2 protein)
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.
programmed cell death 6
, programmed cell death protein 6
, apoptosis-linked gene 2 protein
, probable calcium-binding protein ALG-2