anti-MAP3K8 (MAP3K8) Antikörper

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 Antikörper (MAP3K8)
Auf finden Sie aktuell 105 Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Antikörper von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAP3K8 Proteine (9) und MAP3K8 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 132 MAP3K8 Produkte verfügbar.
c-COT, Cot, Cot/Tpl2, D17TPL2, Est, Estf, MAP3K8, MEKK8, Tpl-2, Tpl2

Meistgesuchte Reaktivitäten zu anti-MAP3K8 (MAP3K8) Antikörper

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anti-Human MAP3K8 Antikörper:

anti-Mouse (Murine) MAP3K8 Antikörper:

anti-Rat (Rattus) MAP3K8 Antikörper:

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Am meisten referenzierte anti-MAP3K8 Antikörper

  1. Human Polyclonal MAP3K8 Primary Antibody für EIA, IHC (p) - ABIN360360 : Shlomchik, Zharhary, Saunders, Camper, Weigert: A rheumatoid factor transgenic mouse model of autoantibody regulation. in International immunology 1994 (PubMed)
    Zeige alle 5 Referenzen für 360360

  2. Human Polyclonal MAP3K8 Primary Antibody für EIA - ABIN358351 : Sánchez-Góngora, Lisbona, de Gregorio, Ballester, Calvo, Pérez-Jurado, Alemany: COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation. in The Journal of biological chemistry 2000 (PubMed)
    Zeige alle 5 Referenzen für 358351

  3. Human Polyclonal MAP3K8 Primary Antibody für IHC, ELISA - ABIN1532057 : Chan, Chedid, McGovern, Popescu, Miki, Aaronson: Expression cDNA cloning of a serine kinase transforming gene. in Oncogene 1993 (PubMed)

  4. Cow (Bovine) Polyclonal MAP3K8 Primary Antibody für WB - ABIN2779366 : Wittwer, Schmitz: NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation. in Biochemical and biophysical research communications 2008 (PubMed)

  5. Cow (Bovine) Polyclonal MAP3K8 Primary Antibody für WB - ABIN2779365 : Jia, Quinn, Bump, Clark, Clabbers, Hardman, Gagnon, Kamens, Tomlinson, Wishart, Allen: Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-kappa B1 p105. in Archives of biochemistry and biophysics 2005 (PubMed)

Weitere Antikörper gegen MAP3K8 Interaktionspartner

Human Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Interaktionspartner

  1. role of p105 (zeige CDH13 Antikörper)/Tpl2 signaling in lung homeostasis

  2. rs1042058 GG Crohn's disease -risk polymorphism in TPL2 results in a gain-of-function by increasing TPL2 expression and signalling, thereby amplifying Pattern recognition receptor -initiated outcomes.

  3. MAP3K8 is a direct target of miR (zeige MLXIP Antikörper)-144-3p, and miR (zeige MLXIP Antikörper)-144-3p downregulation is a factor in renal cell carcinoma (zeige MOK Antikörper) progression through potentiation of MAP3K8 expression.

  4. Taken together, these results suggest that Cot kinase might play a critical role in Helicobacter pylori type IV secretion apparatus-dependent early IL-8 (zeige IL8 Antikörper) secretion and CagA (zeige S100A8 Antikörper)-dependent late IL-8 (zeige IL8 Antikörper) secretion as an alternative signaling molecule in the Erk (zeige EPHB2 Antikörper) pathway.

  5. Studies indicate that Tpl2, a MAP3K, participates in a broad range of cancer-related signaling pathways and induces tumorigenesis and progression of many cancers.

  6. the results of the present study demonstrated that the miR (zeige MLXIP Antikörper)-509-3p RCC (zeige XRCC1 Antikörper) suppressor was a significant regulator of the MAP3K8 oncogene (zeige RAB1A Antikörper), suggesting that it may have a potential therapeutic role in the treatment of renal cell carcinoma (zeige MOK Antikörper)

  7. findings provide a novel perspective on the role of the IL-33 (zeige IL33 Antikörper)/ST2 (zeige SULT2A1 Antikörper)/COT signaling pathway in supporting cancer-associated inflammation in the tumor microenvironment

  8. structurally versatile active site significantly impacts the design of potent, low molecular weight COT kinase inhibitors

  9. TPL2 mediates the phosphorylation of a fraction of nucleophosmin (zeige NPM1 Antikörper) at threonine 199, an event required for its proteasomal degradation and maintenance of steady-state nucleophosmin (zeige NPM1 Antikörper) levels.

  10. MAP3K8 and miR-17-5p expression were inversely correlated with treatment response

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Interaktionspartner

  1. TPL-2-regulated Ccl24 (zeige CCL24 Antikörper) in CD11c (zeige ITGAX Antikörper)+CD11b (zeige ITGAM Antikörper)+ cells prevents accelerated type-2 mediated immunity to H. polygyrus.

  2. role of p105 (zeige NEDD9 Antikörper)/Tpl2 signaling in lung homeostasis

  3. this study shows that TPL-2 deficiency leads to severe house duct mite-induced airway allergy, when compared with wild-type mice

  4. The kinase TPL2 activates ERK (zeige EPHB2 Antikörper) and p38 (zeige CRK Antikörper) signaling to promote neutrophilic inflammation

  5. TPL2 kinase is a crucial signaling factor in iNKT cells and major mediator of hepatic inflammation.

  6. Taken together this study identified that TPL-2 regulated TH2-mediated inflammation by supporting lipolysis and M2 macrophage activation, preventing TH2 cell expansion and downstream immunopathology and fibrosis.

  7. Map3k8 decreases apoptosis of monocytes and enhances CCR2 (zeige CCR2 Antikörper) expression on Ly6C(high)CD11c (zeige ITGAX Antikörper)(low) monocytes of atherosclerotic ApoE (zeige APOE Antikörper)(-/-) mice fed an high fat diet.

  8. results demonstrate that Tpl2 promotes inflammation in part by constraining FoxP3 (zeige FOXP3 Antikörper) expression and Treg immunosuppressive functions.

  9. Tpl2 plays a significant role in promoting HCC (zeige FAM126A Antikörper) development by its pro-inflammatory effect, which suggested that Tpl2 could be a molecular target for HCC (zeige FAM126A Antikörper) prevention.

  10. Tpl2 null mice displayed low COX-2 (zeige COX2 Antikörper) mRNA induction in adipose tissue.

MAP3K8 Antigen-Profil

Beschreibung des Gens

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

Alternative names and synonyms associated with MAP3K8

  • mitogen-activated protein kinase kinase kinase 8 (MAP3K8) Antikörper
  • mitogen-activated protein kinase kinase kinase 8 (map3k8) Antikörper
  • mitogen-activated protein kinase kinase kinase 8 (Map3k8) Antikörper
  • c-COT Antikörper
  • Cot Antikörper
  • Cot/Tpl2 Antikörper
  • D17TPL2 Antikörper
  • Est Antikörper
  • Estf Antikörper
  • MAP3K8 Antikörper
  • MEKK8 Antikörper
  • Tpl-2 Antikörper
  • Tpl2 Antikörper

Bezeichner auf Proteinebene für MAP3K8

mitogen-activated protein kinase kinase kinase 8 , Ewing sarcoma transformant , cot (cancer Osaka thyroid) oncogene , proto-oncogene c-Cot , proto-oncogene serine/threoine protein kinase , tumor progression locus 2 , COT proto-oncogene serine/threonine-protein kinase , cancer Osaka thyroid oncogene , cancer Osaka thyroid, oncogene , mitogen activated protein kinase kinase kinase 8 , serine/threonine-protein kinase cot , serine/threonine kinase (Tpl-2)

450384 Pan troglodytes
100018684 Monodelphis domestica
100063602 Equus caballus
100355566 Oryctolagus cuniculus
100385107 Callithrix jacchus
100480593 Ailuropoda melanoleuca
100541097 Meleagris gallopavo
100562883 Anolis carolinensis
100579516 Nomascus leucogenys
420479 Gallus gallus
1326 Homo sapiens
487085 Canis lupus familiaris
535622 Bos taurus
26410 Mus musculus
116596 Rattus norvegicus
449002 Sus scrofa
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