PCSK1 Proteine (PCSK1)

Bezeichnung:
Proprotein Convertase Subtilisin/kexin Type 1 Proteine (PCSK1)
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Synonyme:
BDP, BMIQ12, Nec-1, Nec1, PC1, PC1/3, PC3, Phpp-1, SPC3
alle Proteine anzeigen Gen GeneID UniProt
PCSK1 5122 P29120
PCSK1 25204 P28840
PCSK1 18548 P63239

Weitere Synonyme anzeigen

PCSK1 Proteine (PCSK1) nach Spezies

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Am meisten referenzierte PCSK1 Proteine

  1. Human PCSK1 Protein expressed in Human Cells - ABIN2002138 : Jackson, Creemers, Farooqi, Raffin-Sanson, Varro, Dockray, Holst, Brubaker, Corvol, Polonsky, Ostrega, Becker, Bertagna, Hutton, White, Dattani, Hussain, Middleton, Nicole, Milla, Lindley, ORahilly: Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. in The Journal of clinical investigation 2003 (PubMed)
    Zeige alle 4 Referenzen für 2002138

Weitere Proteine zu PCSK1 Interaktionspartnern

Zebrafish Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) Interaktionspartner

  1. Pcsk1 has been sequenced and characterized.

Human Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) Interaktionspartner

  1. PCSK1 mutations are associated with Obesity.

  2. PCSK1 expression is significantly upregulated in human masticatory mucosa during wound healing

  3. these common variants in PCSK1 and POMC (zeige POMC Proteine) were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 did affect cholesterol level, LDL-C level, and waist circumference.

  4. we demonstrate evidence that common gene variation in PCSK1 contributes to BMI variation and susceptibility to common obesity in the largest known meta-analysis published to date in genetic epidemiology.

  5. Data show that prohormone convertase 1/3 (PC1/3) endoplasmic reticulum-retained mutants induce endoplasmic reticulum stress.

  6. Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3.

  7. We showed for the first time that a nonsense mutation in PCSK1 was likely to cause dominantly inherited human obesity, due to the inhibiting properties of the propeptide fragment encoded by the null allele

  8. Epistases between single nucleotide polymorphisms within proprotein convertase subtilisin/kexin type 1(PCSK1) and dopamine beta-hydroxylase(DBH (zeige DBH Proteine)) genes are significantly associated with susceptibility or resistance to premature ovarian failure

  9. FTO (zeige FTO Proteine)-rs9939609, TMEM18 (zeige TMM18 Proteine)-rs6548238 and PCSK1-rs6234 polymorphisms are significantly associated with body mass index in a southern Chinese population.

  10. Common genetic variants in PCSK1 are associated with coronary artery disease in Chinese patients with type 2 diabetes.

Cow (Bovine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) Interaktionspartner

  1. Prohormone convertase PC1 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.

  2. a model of the membrane topology of the prohomone convertase PC3, where it is anchored to lipid rafts in secretory granule membranes via the transmembrane domain

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) Interaktionspartner

  1. macrophages from PC1/3 KO mice and rat PC1/3-KD NR8383 macrophages secreted more pro-inflammatory cytokines such as TNF-alpha (zeige TNF Proteine), IL6 (zeige IL6 Proteine), IL1alpha (zeige IL1A Proteine) and CXCL2 (zeige CXCL2 Proteine).

  2. PC1 and PC2 (zeige CBX4 Proteine) are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 (zeige TAC1 Proteine) protein

  3. Binding of MAGP2 (zeige MFAP5 Proteine) to microfibrils is regulated by proprotein convertase cleavage.

  4. Data indicate that the mutant PC1/3-N222D protein coimmunoprecipitates with wildtype(WT) prohormone convertase 1/3 (PC1/3) and exerts a modest effect on intracellular retention of the WT enzyme.

  5. proSAAS (zeige PCSK1N Proteine) as a novel down-regulated target of Pax6 (zeige PAX6 Proteine)

  6. Loss of PC1 in mice showed a dramatic decrease in the biosynthesis of all proTRH-derived peptides analyzed including TRH (zeige TRH Proteine) and its immediate precursor TRH (zeige TRH Proteine)-Gly.

  7. PC1/3 also has an important role in the regulation of the innate immune system, most likely through the regulation of cytokine secretion in macrophages.

  8. Reports demonstrate that mouse proprotein convertase 1/3 (mPC1 (zeige BRP44L Proteine)/3) has a lag (zeige STMN1 Proteine) phase of activation by substrates that can be interpreted as a hysteretic behavior of the enzyme for their hydrolysis.

  9. Intraislet production of GLP-1 (zeige GCG Proteine) by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of ss-cell regeneration.

  10. Data suggest that PC1/3 and many convertase-specific properties are attributable less to convertase-specific catalytic cleft residues than to convertase-specific domain interactions.

Pig (Porcine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) Interaktionspartner

  1. Study identified 14 polymorphisms that were organized in nine haplotypes, clearly distributed in two clades of putative European and Asian origin and showed that the porcine PCSK1 gene is associated with fat deposition.

PCSK1 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PCSK1

  • proprotein convertase subtilisin/kexin type 1 (pcsk1)
  • prohormone convertase 1 (PC1B)
  • prohormone convertase 1 (LOC100534403)
  • prohormone convertase 1 (LOC100534404)
  • proprotein convertase subtilisin/kexin type 1 (PCSK1)
  • proprotein convertase subtilisin/kexin type 1 (Pcsk1)
  • BDP Protein
  • BMIQ12 Protein
  • Nec-1 Protein
  • Nec1 Protein
  • PC1 Protein
  • PC1/3 Protein
  • PC3 Protein
  • Phpp-1 Protein
  • SPC3 Protein

Bezeichner auf Proteinebene für PCSK1

neuroendocrine convertase 1 , prohormone convertase 1 , NEC 1 , prohormone convertase 3 , Protein convertase subtilisin / kexin type I , Protein convertase subtilisin / kexin, type I , proprotein convertase 1 , furin homolog , prohormone convertase 1/3 , propeptide-processing protease , prohormone convertase

GENE ID SPEZIES
100005716 Danio rerio
100533213 Aplysia californica
100534403 Oreochromis niloticus
100534404 Oreochromis niloticus
5122 Homo sapiens
25204 Rattus norvegicus
281967 Bos taurus
18548 Mus musculus
479149 Canis lupus familiaris
397103 Sus scrofa
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