TNFRSF10B Proteine (TNFRSF10B)

Tumor Necrosis Factor Receptor Superfamily, Member 10b Proteine (TNFRSF10B)
Auf finden Sie aktuell 47 Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Proteine von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TNFRSF10B Antikörper (373) und TNFRSF10B Kits (14) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 454 TNFRSF10B Produkte verfügbar.
alle Proteine anzeigen Gen GeneID UniProt
Ratte TNFRSF10B TNFRSF10B 364420  
TNFRSF10B 8795 O14763
TNFRSF10B 21933 Q9QZM4

Weitere Synonyme anzeigen

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Am meisten referenzierte TNFRSF10B Proteine

  1. Human TNFRSF10B Protein expressed in HEK293 - ABIN925132 : Schneider, Bodmer, Thome, Hofmann, Holler, Tschopp: Characterization of two receptors for TRAIL. in FEBS letters 1997 (PubMed)
    Zeige alle 2 Referenzen für 925132

  2. Human TNFRSF10B Protein expressed in Human Cells - ABIN2002897 : Pan, Ni, Wei, Yu, Gentz, Dixit: An antagonist decoy receptor and a death domain-containing receptor for TRAIL. in Science (New York, N.Y.) 1997 (PubMed)

  3. Human TNFRSF10B Protein expressed in HEK-293 Cells - ABIN2181868 : Yamaguchi, Wang: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. in The Journal of biological chemistry 2004 (PubMed)

Weitere Proteine zu TNFRSF10B Interaktionspartnern

Human Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Interaktionspartner

  1. Study provides direct biophysical evidence that Death Receptor 5 disulfide-linked transmembrane (TM)-dimers open in response to ligand binding. Then, to probe the importance of the closed-to-open TM domain transition in the overall energetics of receptor activation, point-mutants (alanine to phenylalanine) in the predicted, tightly packed TM domain dimer interface were designed and tested.

  2. High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancer cells and xenograft tumors.

  3. Oridonin analog CYD (zeige CYBB Proteine)-6-28 induces apoptosis at least partially by inducing the expression of death receptor 5 in breast neoplasms.

  4. The authors show that cholesterol is necessary for the covalent dimerization of DR5 transmembrane domains.

  5. Mono treatment with lexatumumab was not sufficient to induce apoptosis in pancreatic cancer cells, whereas focal adhesion kinase inhibitor PF573228 significantly sensitized lexatumumab-induced apoptosis. Western blotting analysis revealed that lexatumumab and PF573228 combination treatment increased death receptor 5 but decreased Bcl-xL (zeige BCL2L1 Proteine) expression.

  6. We demonstrate that PBOX-15 can enhance TRAIL-induced apoptosis by upregulation of DR5, reduction of cellular mitochondrial potential, activation of the caspase (zeige CASP3 Proteine) cascade and downregulation of PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine), c-FLIP (zeige CFLAR Proteine), Mcl-1 (zeige MCL1 Proteine) and IAP (zeige ALPI Proteine) survival pathways

  7. The nanovectorization of TRAIL enhanced its binding to both DR4 (zeige HLADRB4 Proteine) and DR5 receptors at 37 degrees C and could potentially sensitized cancer cells to TRAIL induced apoptosis through simultaneous activation of DR4 (zeige HLADRB4 Proteine) and DR5 as described in this paper for the non-small lung carcinoma cell line (H1703), the two hepatocarcinoma cell lines (SK-Hep1, HUH) and the colon carcinoma cell line (HCT116WT).

  8. we found that CQ decreased the expression of Cbl (zeige CBL Proteine), an E3 ligase of DR5, and knock-down of Cbl (zeige CBL Proteine) markedly enhanced DR5 up-regulation. Other lysosomal inhibitors, including monensin and nigericin, also up-regulated DR5 and sensitized TRAIL-mediated apoptosis

  9. MG132 possesses anti-gallbladder cancer potential that correlate with regulation of DR5-dependent pathway.

  10. Edelfosine also activated p38MAPK (MAPK14 (zeige MAPK14 Proteine)), and edelfosine-mediated rhTRAIL sensitization was partially regulated by a p38 (zeige CRK Proteine)-mediated decrease in mitochondrial membrane potential. This study suggests a novel therapeutic strategy targeting gastric cancer cells by using the combination of edelfosine and TRAIL.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Interaktionspartner

  1. Authors demonstrate, for the first time, expression of TNF-related apoptosis-inducing ligand (TRAIL (zeige TNFSF10 Proteine)) and its signaling death receptor 5 (DR5) in the murine inner ear.

  2. Malignant transformation in the endometrium is related to reduction of membrane DR4 (zeige HLADRB4 Proteine) and DR5 expression.

  3. TRAIL expression by osteoclast-like cells is increased in the presence of RANKL (zeige TNFSF11 Proteine) and after scraping; DcR2 (zeige TNFRSF10D Proteine) expression peaks at 24 hours, and and decreases at 5 days; DR5 expression peaks at 5 days

  4. Induction of death receptor 5 expression in tumor vasculature by perifosine restores the vascular disruption activity of TRAIL-expressing CD34 (zeige CD34 Proteine)(+) cells.

  5. TRAIL-DR5 interaction promoted malignant behaviors of B16F10 cells.

  6. results suggest that the transmembrane domains together with their adjacent stalk regions can play a major role in control of death receptor activation thereby contributing to cell type specific differences in TRAILR1 and TRAILR2 signaling

  7. DR5 is selectively expressed by neuroprogenitor cells and newborn neurons.

  8. Results suggest that excessive iodine could induce TRAIL and DR5 abnormal expression in thyroid. TRAIL band with DR5 to promote follicular cells apoptosis thus mediate thyroid destruction in EAT.

  9. NK cells inhibit dendritic cell cross-priming, but not direct priming, in a TRAIL/DR5-dependent manner.

  10. Antibody-based therapy targeting DR5 is an efficient strategy not only to eliminate TRAIL-sensitive tumor cells.

TNFRSF10B Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Alternative names and synonyms associated with TNFRSF10B

  • tumor necrosis factor receptor superfamily, member 10b (Tnfrsf10b)
  • tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B)
  • tumor necrosis factor receptor superfamily, member 10b (tnfrsf10b-b)
  • tumor necrosis factor receptor superfamily, member 10b (tnfrsf10b)
  • CD262 Protein
  • DR5 Protein
  • KILLER Protein
  • KILLER/DR5 Protein
  • Ly98 Protein
  • MK Protein
  • TNFRSF10B Protein
  • TRAIL-R2 Protein
  • TRAILR2 Protein
  • TRICK2 Protein
  • TRICK2A Protein
  • TRICK2B Protein
  • TRICKB Protein
  • xDR-M1 Protein
  • xDR-M2 Protein
  • ZTNFR9 Protein

Bezeichner auf Proteinebene für TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b , death receptor-M2 , death receptor-M1 , Fas-like protein , TNF-related apoptosis-inducing ligand receptor 2 , apoptosis inducing protein TRICK2A/2B , apoptosis inducing receptor TRAIL-R2 , cytotoxic TRAIL receptor-2 , death domain containing receptor for TRAIL/Apo-2L , death receptor 5 , p53-regulated DNA damage-inducible cell death receptor(killer) , tumor necrosis factor receptor superfamily member 10B , tumor necrosis factor receptor-like protein ZTNFR9 , KILLER/DR5 TRAIL death-inducing receptor

364420 Rattus norvegicus
282533 Bos taurus
404687 Xenopus laevis
404688 Xenopus laevis
448240 Xenopus (Silurana) tropicalis
742898 Pan troglodytes
8795 Homo sapiens
21933 Mus musculus
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