anti-PIDD (PIDD) Antikörper

anti-P53-Induced Death Domain Protein Antikörper (PIDD)
Auf finden Sie aktuell 44 P53-Induced Death Domain Protein (PIDD) Antikörper von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PIDD Proteine (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 51 PIDD Produkte verfügbar.
1200011D09Rik, AU042446, Lrdd, Pidd

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anti-Mouse (Murine) PIDD Antikörper:

anti-Human PIDD Antikörper:

anti-Rat (Rattus) PIDD Antikörper:

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Am meisten referenzierte anti-PIDD Antikörper

  1. Human Polyclonal PIDD Primary Antibody für IP, IHC - ABIN1169268 : Tinel, Tschopp: The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. in Science (New York, N.Y.) 2004 (PubMed)
    Zeige alle 3 Referenzen für 1169268

  2. Human Monoclonal PIDD Primary Antibody für IHC, IHC (p) - ABIN4331451 : Tinel, Janssens, Lippens, Cuenin, Logette, Jaccard, Quadroni, Tschopp: Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. in The EMBO journal 2007 (PubMed)
    Zeige alle 2 Referenzen für 4331451

Weitere Antikörper gegen PIDD Interaktionspartner

Mouse (Murine) P53-Induced Death Domain Protein (PIDD) Interaktionspartner

  1. NPM1 (zeige GJA1 Antikörper)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (zeige CASP2 Antikörper) activation cascade.

  2. PIDD acts as a critical switcher between the NF-kappabeta (zeige NFKB1 Antikörper) transcription pathway and radiation-induced apoptosis

  3. The tumor-modulatory effects of Caspase-2 (zeige CASP2 Antikörper) and Pidd1 do not require the scaffold protein (zeige HOMER1 Antikörper) Raidd (zeige CRADD Antikörper)

  4. Loss of PIDD leads to an impaired inflammatory response after DNA damage.

  5. Caspase 2 (zeige CASP2 Antikörper) activity can be induced in neurons from PIDD-null mice, and NGF (zeige NGFB Antikörper) deprivation or Abeta (zeige APP Antikörper) use caspase 2 (zeige CASP2 Antikörper) and RAIDD (zeige CRADD Antikörper) to execute death of these neurons.

  6. P450 (zeige POR Antikörper) levels were higher in female DES (zeige DES Antikörper)-treated p53 (zeige TP53 Antikörper)+/- mice compared to treated wild type mice.

  7. Results suggest that at least one alternative PIDDosome-independent mechanism of caspase-2 (zeige CASP2 Antikörper) activation exists in mammals in response to DNA damage.

  8. PIDD does not play an essential role for all p53 (zeige TP53 Antikörper)-mediated or p53 (zeige TP53 Antikörper)-independent apoptotic pathways.

Human P53-Induced Death Domain Protein (PIDD) Interaktionspartner

  1. NPM1 (zeige NPM1 Antikörper)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (zeige CASP2 Antikörper) activation cascade.

  2. PIDD expression was lower in HCC (zeige FAM126A Antikörper) tissues and HCC (zeige FAM126A Antikörper) cell lines, compared with the adjacent non-tumorous tissues and LO2 normal hepatocytes. PIDD could serve as an independent prognostic factor to predict the survival of HCC (zeige FAM126A Antikörper) patients. PIDD facilitated cell cycle progression and accelerated cell proliferation in HepG2 cells, while overexpression of PIDD resulted in cell cycle arrest at G1 phase in Hep3B cells.

  3. By sequestering PIDD at the kinetochore, BubR1 (zeige BUB1B Antikörper) acts to delay PIDDosome formation until the next cycle, defining a new mechanism by which cells evade apoptosis during mitosis.

  4. The ATM (zeige ATM Antikörper) phosphorylation of the PIDD DD enables a binary switch through which cells elect to survive or die upon DNA injury.

  5. PIDD performs key functions upon UV irradiation, including TLS (zeige FUS Antikörper), NHEJ, NF-kappaB (zeige NFKB1 Antikörper) activation and cell death.

  6. Hsp90 (zeige HSP90 Antikörper) has a major role in controlling PIDD functional activity.

  7. a new splicing variant of PIDD named PIDD4 is reported.

  8. point mutations on RAIDD (zeige CRADD Antikörper) (R147E) and on PIDD (Y814A) exert a dominant negative effect on the formation of the PIDDosome, and that this effect cannot be applied after the PIDDosome has been formed

  9. Total caspase-2 (zeige CASP2 Antikörper) is upregulated during tumour progression in renal cell carcinomas.

  10. activation of caspase-2 (zeige CASP2 Antikörper) occurs in a complex that contains PIDD, whose expression is induced by p53 (zeige TP53 Antikörper), and RAIDD (zeige CRADD Antikörper); increased PIDD expression resulted in spontaneous activation of caspase-2 (zeige CASP2 Antikörper) and sensitization to apoptosis by genotoxic stimuli

PIDD Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with PIDD

  • leucine-rich and death domain containing (Lrdd) Antikörper
  • p53-induced death domain protein (PIDD) Antikörper
  • p53-induced death domain protein (Pidd) Antikörper
  • 1200011D09Rik Antikörper
  • AU042446 Antikörper
  • Lrdd Antikörper
  • Pidd Antikörper

Bezeichner auf Proteinebene für PIDD

leucine-rich repeat and death domain-containing protein , p53 protein induced, with death domain , p53-induced protein with a death domain , leucine-rich repeats and death domain containing

57913 Mus musculus
55367 Homo sapiens
293625 Rattus norvegicus
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