anti-BBC3 (BBC3) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 298 BCL2 Binding Component 3 (BBC3) Antikörper von 27 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen BBC3 Kits (13) und BBC3 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 338 BBC3 Produkte verfügbar.
Synonyme:
BBC3, JFY-1, JFY1, PUMA, PUMA/JFY1
Alle Antikörper anzeigen Gen GeneID UniProt
BBC3 317673 Q80ZG6
BBC3 27113 Q96PG8 , Q9BXH1
BBC3 170770 Q99ML1

Meistgesuchte Reaktivitäten zu anti-BBC3 (BBC3) Antikörper

anti-Rat (Rattus) BBC3 Antikörper:

anti-Human BBC3 Antikörper:

anti-Mouse (Murine) BBC3 Antikörper:

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Weitere Antikörper gegen BBC3 Interaktionspartner

Human BCL2 Binding Component 3 (BBC3) Interaktionspartner

  1. Results show that in PUMA protein adenovirus-infected A2780s ovarian cancer cells, exogenous PUMA was partially accumulated in the cytosol and mainly located to the mitochondria.

  2. Inhibition of mTORC1-mediated 4EBP1 (zeige EIF4EBP1 Antikörper) phosphorylation leads to decreased expression of c-MYC (zeige MYC Antikörper) and subsequent upregulation of the proapoptotic BCL2 (zeige BCL2 Antikörper) family member PUMA, whereas inhibition of mTORC2 (zeige CRTC2 Antikörper) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (zeige EGR1 Antikörper)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (zeige BCL2L11 Antikörper) locus encoding BIM (zeige BCL2L11 Antikörper).

  3. These results demonstrated the involvement of BBC3/Bbc3 in cold preservation/rewarming-mediated islet injury, possibly through modulating HMGB1 (zeige HMGB1 Antikörper)- and oxidative stress-mediated injury to islets.

  4. miR (zeige MLXIP Antikörper)-23a-3p, miR (zeige MLXIP Antikörper)-23b-3p, and miR (zeige MLXIP Antikörper)-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 (zeige BCL2 Antikörper) proteins DP5 (zeige HRK Antikörper) and PUMA and consequent human beta-cell apoptosis.

  5. Our results revealed that Slug (zeige SNAI2 Antikörper) siRNA transfection in combination with radiation increased the expression of PUMA, which contributed to radiosensitivity of oral squamous cell carcinoma cells

  6. p53 (zeige TP53 Antikörper) and Bax (zeige BAX Antikörper) might play an important role in microcystin-LR (MC-LR)-induced apoptosis in HepG2 cells in which PUMA and survivin (zeige BIRC5 Antikörper) were involved.

  7. Therapeutic response to non-genotoxic activation of p53 (zeige TP53 Antikörper) by Nutlin3a is driven by PUMA-mediated apoptosis in lymphoma cells.

  8. p53 (zeige TP53 Antikörper)/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis

  9. Suggest that the accumulation of PUMA in the cytosol may be important for the participation of this protein in apoptosis without the need for prior transcription in Burkitt's lymphoma b cells.

  10. in vitro OGT (zeige OGT Antikörper) knockdown induced more cell apoptosis through increasing PUMA and caspase-3 (zeige CASP3 Antikörper) expression

Mouse (Murine) BCL2 Binding Component 3 (BBC3) Interaktionspartner

  1. Data show that Emu-Myc (zeige MYC Antikörper) mice lacking both p21 (zeige D4S234E Antikörper) and PUMA developed lymphoma at a rate considerably longer latency than Emu-Myc (zeige MYC Antikörper);p53 (zeige TP53 Antikörper)(+/-)mice.

  2. Our data show a novel pathway of infection-induced apoptosis that enhances our understanding of the mechanism by which BH3-only proteins control apoptotic host cell death during Listeria infection.

  3. Overexpression of miR (zeige MLXIP Antikörper)-29 or miR (zeige MLXIP Antikörper)-24 is sufficient to inhibit the induction of Bim (zeige BCL2L11 Antikörper) and Puma in young sympathetic neurons.

  4. loss of PUMA had no impact on the loss of platelets caused by loss of BCL-XL (zeige BCL2L1 Antikörper). It therefore remains to be established whether other BH3-only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between BCL-XL (zeige BCL2L1 Antikörper) with BAK (zeige BAK1 Antikörper) and BAX (zeige BAX Antikörper).

  5. PUMA is dispensable for glucose homeostasis in lean and obese mice, but it can affect leptin (zeige LEP Antikörper) levels and food intake during obesity.

  6. MYSM1 (zeige MYSM1 Antikörper) is a critical negative regulator of p53 (zeige TP53 Antikörper) transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cel function.

  7. Therapeutic response to non-genotoxic activation of p53 (zeige TP53 Antikörper) by Nutlin3a is driven by PUMA-mediated apoptosis in lymphoma cells.

  8. Bim (zeige BCL2L11 Antikörper) and Puma overlapped apoptosis only partially during physiological apoptotic stage and they were present in non-apoptotic parts of the follicles.

  9. Beta-arrestin 2 (zeige ARRB2 Antikörper) promotes inflammation-induced intestinal epithelial apoptosis through endoplasmic reticulum stress/PUMA in colitis.

  10. Puma is the major mediator of virus-induced Bax (zeige BAX Antikörper)/Bak (zeige BAK1 Antikörper) activation and mitochondrial membrane permeabilization induction.

Zebrafish BCL2 Binding Component 3 (BBC3) Interaktionspartner

  1. Bad functions as an essential sensitizer and Puma as an essential activator of IR-induced mitochondrial apoptosis specifically in embryonic neural tissue.

  2. Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin (zeige TUBA4A Antikörper) mutation

BBC3 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with BBC3

  • BCL2 binding component 3 (BBC3) Antikörper
  • Bcl-2 binding component 3 (Bbc3) Antikörper
  • BCL2 binding component 3 (Bbc3) Antikörper
  • BCL2 binding component 3 (bbc3) Antikörper
  • BBC3 Antikörper
  • JFY-1 Antikörper
  • JFY1 Antikörper
  • PUMA Antikörper
  • PUMA/JFY1 Antikörper

Bezeichner auf Proteinebene für BBC3

BCL2 binding component 3 , bcl-2-binding component 3 , p53 up-regulated modulator of apoptosis , BH3-only , Bcl-2 binding component 3 , Puma

GENE ID SPEZIES
612153 Canis lupus familiaris
746617 Pan troglodytes
317673 Rattus norvegicus
27113 Homo sapiens
170770 Mus musculus
751763 Danio rerio
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