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The study shows that FXR (zeige NR1H4 Proteine)/RXR regulates Chop (zeige DDIT3 Proteine) expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.
These results suggest a mechanism to establish RXR therapeutic targets with significance in neurodegeneration.
The optimal PPARalpha (zeige PPARA Proteine)/RXRalpha heterodimer binding sequence was WAWVTRGGBBAHRGKTYA. The single nucleotide substitution, which reduces binding of RXRalpha to DNA, attenuated PPARalpha (zeige PPARA Proteine)-induced transcriptional activation, but this is not always true for PPARalpha (zeige PPARA Proteine).
A change in the heterodimeric partner of Peroxisome Proliferator Activated Receptor-alpha (zeige PPARA Proteine) from retinoid X receptor (zeige RXRB Proteine) to Silent information regulator 1 is responsible for the impaired fatty acid metabolism and cardiac dysfunction in the failing heart.
interaction of Wnt and RXR-alpha pathways in hepatocyte development and hepatocellular carcinoma
a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 and PTEN
This uncovered a novel RXR-dependent innate immune regulatory pathway, suggesting that downregulation of RXR expression or RXR antagonist treatment benefits host antiviral response, whereas RXR agonist treatment may increase risk of viral infections.
Data suggest that retinoic acid and GM-CSF (zeige CSF2 Proteine)-induced retinal dehydrogenase 2 (RALDH2 (zeige ALDH1A2 Proteine)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (zeige SP1 Proteine) via the RA receptor/retinoid X receptor (zeige RXRB Proteine) complex to the Aldh1a2 (zeige ALDH1A1 Proteine) promoter.
The expression and binding of RXRalpha to CYP3A genes in liver was sex-dependent and regulated by growth hormone secretion.
The depletion of retinoic acid and the inhibition of RXRalpha function in hepatic tumors involve more complex mechanisms besides the activation of RAS/ERK (zeige EPHB2 Proteine) pathway.
Immune cell-infiltration is controlled by activated peroxisome proliferator activated receptor gamma (PPARgamma (zeige PPARG Proteine))/retinoid X receptor alpha (RXRalpha) that inhibits expression/secretion of inflammatory cytokines.
Data suggest that the binding of Z-10 to RXRalpha inhibited the interaction of RXRalpha with PML (zeige PML Proteine)-RARalpha (zeige RARA Proteine), leading to Z-10's selective induction of PML (zeige PML Proteine)-RARalpha (zeige RARA Proteine) degradation.
This suggests that hRXRalpha phosphorylation significantly disrupts its nuclear localization, interaction with VDR, intra-nuclear trafficking, and binding to chromatin of the hVDR-hRXR complex.
the expression of CAMP, vitamin D receptor (VDR), and the retinoid X receptor (RXR) isoforms in human skin and gingival tissue biopsies and investigated the signaling pathways involved in 1alpha,25-dihydroxyvitamin D3-induced upregulation of CAMP.
data show that RXRalpha expression is increased in miscarriage in endometrial glands and correlation analysis showed that negative correlation between RXRalpha and PPARgamma (zeige PPARG Proteine) disappears in miscarriage. This shift is supposable responsible for the loss of regular function in trophoblast and embryonic tissue.
IL-1beta (zeige IL1B Proteine) upregulated RXRalpha through activation of NF-kappaB (zeige NFKB1 Proteine) signaling.
RXRA rs10776909 allele T is specifically involved in the pathogenesis of ChGN (zeige CSGALNACT1 Proteine). This risk allele may be also associated with worse clinical course of ChGN (zeige CSGALNACT1 Proteine).
Results suggest that retinoid X receptor (zeige RXRB Proteine) (RXR) activation protects retinal pigment epithelium (RPE (zeige RPE Proteine)) cells from oxidative stress-induced (zeige SQSTM1 Proteine) apoptosis.
Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively.
Retinoid X receptor alpha plays an important role in proliferation of cholangiocarcinoma
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.
retinoid X receptor, alpha
, retinoid X receptor alpha
, RXR alpha 1
, nuclear receptor subfamily 2 group B member 1
, retinoic acid receptor RXR-alpha
, retinoid X nuclear receptor alpha
, retinoic acid receptor
, retinoid x receptor alpha
, retinoid X receptor alpha protein
, nuclear receptor subfamily 2 group B member 2-A
, retinoic acid receptor RXR-beta-A
, retinoid X receptor beta-A
, retinoid receptor-epsilon
, retinoid x receptor, epsilon