anti-Presenilin 2 (PSEN2) Antikörper

Bezeichnung:
anti-Presenilin 2 (Alzheimer Disease 4) Antikörper (PSEN2)
Auf www.antikoerper-online.de finden Sie aktuell 142 Presenilin 2 (Alzheimer Disease 4) (PSEN2) Antikörper von 22 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Presenilin 2 Kits (31) und Presenilin 2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 184 Presenilin 2 Produkte verfügbar.
Synonyme:
AD3L, AD4, Ad4h, ALG-3, Alg3, CMD1V, pre2, PS-2, PS2, PSEN2, PSNL2, STM2, zf-PS2

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anti-Rat (Rattus) Presenilin 2 Antikörper:

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Am meisten referenzierte anti-Presenilin 2 Antikörper

  1. Human Polyclonal Presenilin 2 Primary Antibody für WB - ABIN1944732 : Li, Ma, Potter: Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Zeige alle 4 Referenzen für 1944732

  2. Human Polyclonal Presenilin 2 Primary Antibody für EIA, WB - ABIN493378 : Hansson, Popescu, Laudon, Cedazo-Minguez, Popescu, Winblad, Ankarcrona: Caspase cleaved presenilin-1 is part of active gamma-secretase complexes. in Journal of neurochemistry 2006 (PubMed)
    Zeige alle 2 Referenzen für 493378

  3. Cow (Bovine) Polyclonal Presenilin 2 Primary Antibody für IHC, WB - ABIN2781802 : da Costa: Recent insights on the pro-apoptotic phenotype elicited by presenilin 2 and its caspase and presenilinase-derived fragments. in Current Alzheimer research 2005 (PubMed)

  4. Human Polyclonal Presenilin 2 Primary Antibody für EIA, IHC (fro) - ABIN318338 : Levy-Lahad, Wasco, Poorkaj, Romano, Oshima, Pettingell, Yu, Jondro, Schmidt, Wang: Candidate gene for the chromosome 1 familial Alzheimer's disease locus. in Science (New York, N.Y.) 1995 (PubMed)

Weitere Antikörper gegen Presenilin 2 Interaktionspartner

Mouse (Murine) Presenilin 2 (Alzheimer Disease 4) (PSEN2) Interaktionspartner

  1. Presenilin 2 (PS2), mutations in which underlie familial Alzheimer's disease (FAD (zeige FANCD2 Antikörper)), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2 (zeige MFN2 Antikörper)).

  2. Study shows that the binding of HSF-1 (zeige HSF1 Antikörper), Cdx1 (zeige CDX1 Antikörper), Ets-1 (zeige ETS1 Antikörper) and Sp1 (zeige SP1 Antikörper) to Presenilin 1 (zeige PSEN1 Antikörper) promoter and that of Nkx2.2 (zeige Nkx2-2 Antikörper), HFH-2 (zeige FOXD3 Antikörper), Cdx1 (zeige CDX1 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) to Presenilin 2 promoter regulate their differential expression during brain development.

  3. ARF4 (zeige ARF4 Antikörper) is required for Presenilin basal body localization, Notch (zeige NOTCH1 Antikörper) signaling, and subsequent epidermal differentiation.

  4. Results suggest that mutation of PS2 (zeige PDCD6 Antikörper) can lead to NF-kappaB (zeige NFKB1 Antikörper) mediate amyloidogensis, and this effect can be amplified by the absence of estrogen.

  5. Results showed that epigenetic mechanisms play a pivotal role in transcriptional regulation of PS1 (zeige PSEN1 Antikörper) and PS2 (zeige PDCD6 Antikörper) during cerebral cortical development

  6. This study presents novel evidence for the differential expression of PS proteins in a nongenetic model for aging, resulting in an overall increase of the PS2 (zeige PDCD6 Antikörper) to PS1 (zeige PSEN1 Antikörper) ratio.

  7. The loss of PS2 (zeige PDCD6 Antikörper) could have a critical role in lung tumor development through the upregulation of iPLA2 (zeige PLA2G6 Antikörper) activity by reducing gamma-secretase.

  8. One mechanism by which PS2 (zeige PDCD6 Antikörper) works to reign in proinflammatory microglial behavior and PS2 (zeige PDCD6 Antikörper) dysfunction or deficiency could result in unchecked proinflammatory activation. contributing to neurodegeneration.

  9. At the transcriptional level, Psen1/2 removal induced cyclic AMP response element-binding protein (CREB)/CREB-binding protein binding.

  10. Upregulation of PS1 (zeige PSEN1 Antikörper)/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease.

Zebrafish Presenilin 2 (Alzheimer Disease 4) (PSEN2) Interaktionspartner

  1. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation.

  2. These results suggest that Psen2 plays a more prominent role in Notch (zeige NOTCH1 Antikörper) signalling and embryo development in zebrafish than in mammals, and that the effect of reduced Psen2 can be ameliorated by Psen1 (zeige PSEN1 Antikörper) loss.

Human Presenilin 2 (Alzheimer Disease 4) (PSEN2) Interaktionspartner

  1. Presenilin 2 (PS2), mutations in which underlie familial Alzheimer's disease (FAD (zeige BRCA2 Antikörper)), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2 (zeige MFN2 Antikörper)).

  2. The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. It started from the discovery of fully penetrant mutations in Amyloid precursor protein (zeige APP Antikörper), Presenilin 1 (zeige PSEN1 Antikörper), and Presenilin 2 as a cause of autosomal dominant AD

  3. Data show that presenilin 1 (PS1 (zeige PSEN1 Antikörper))/anterior-pharynx-defective protein 1 (Aph1b (zeige aph1b Antikörper)), presenilin 2 (PS2)/Aph1aL, PS2/Aph1aS and PS2/anterior pharynx defective 1 homolog B (Aph1b (zeige aph1b Antikörper)) gamma-secretase produced amyloid beta peptide (Abeta (zeige APP Antikörper)) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases.

  4. This review reveled that Mutations in APP (zeige APP Antikörper) and PS-1 (zeige PSEN1 Antikörper) and PS-2 genes that are associated with early-onset, autosomal, dominantly inherited AD.

  5. Most of the early-onset Alzheimer's disease -associated mutations have been detected in PSEN1 (zeige PSEN1 Antikörper), and several novel PSEN1 (zeige PSEN1 Antikörper) mutations were recently identified in patients from various parts of the world, including Asia. Until 2014, no PSEN2 mutations were found in Asian patients; however, emerging studies from Korea and the People's Republic of China discovered probably pathogenic PSEN2 mutations. [review]

  6. Familial Alzheimer's disease Patients with PSEN2 mutations have a delayed AOO with longest disease duration and presented more frequently with disorientation. [review]

  7. Study identified a unique motif in PSEN2 that directs gamma-secretase to late endosomes/lysosomes via a phosphorylation-dependent interaction with the AP-1 (zeige FOSB Antikörper) adaptor complex. PSEN2 selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular Abeta (zeige APP Antikörper) that contains longer Abeta (zeige APP Antikörper); familial Alzheimer's disease-associated mutations in PSEN2 increased the levels of longer Ab...

  8. Data show that presenilin 1 (PS1 (zeige PSEN1 Antikörper))-containing gamma-secretase complexes were targeted to the plasma membrane, whereas presenilin 2 (PS2)-containing ones were addressed to the trans-Golgi network, to recycling endosomes.

  9. German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants.

  10. This study identified variants in PSEN2 across a range of phenotypes (Alzheimer's Disease , Alzheimer's Disease and cerebrovascular disease,frontotemporal dementia and progressive supranuclear palsy.

Presenilin 2 (PSEN2) Antigen-Profil

Beschreibung des Gens

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Alternative names and synonyms associated with Presenilin 2 (PSEN2)

  • presenilin 2 (Alzheimer disease 4) (PSEN2) Antikörper
  • presenilin 2 (Alzheimer disease 4) (psen2) Antikörper
  • presenilin 2 (Psen2) Antikörper
  • presenilin 2 (psen2) Antikörper
  • presenilin-2-like (LOC100717114) Antikörper
  • AD3L Antikörper
  • AD4 Antikörper
  • Ad4h Antikörper
  • ALG-3 Antikörper
  • Alg3 Antikörper
  • CMD1V Antikörper
  • pre2 Antikörper
  • PS-2 Antikörper
  • PS2 Antikörper
  • PSEN2 Antikörper
  • PSNL2 Antikörper
  • STM2 Antikörper
  • zf-PS2 Antikörper

Bezeichner auf Proteinebene für PSEN2

presenilin 2 (Alzheimer disease 4) , presenilin-2 , PS-2 , AD3LP , AD5 , E5-1 , STM-2 , PS-beta , presenilin beta , presenilin-beta

GENE ID SPEZIES
457790 Pan troglodytes
549935 Xenopus (Silurana) tropicalis
698770 Macaca mulatta
100596029 Nomascus leucogenys
81751 Rattus norvegicus
19165 Mus musculus
58026 Danio rerio
5664 Homo sapiens
397713 Xenopus laevis
374188 Gallus gallus
490382 Canis lupus familiaris
780410 Sus scrofa
282010 Bos taurus
100172138 Pongo abelii
100717114 Cavia porcellus
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