anti-Obscurin (OBSCN) Antikörper

Bezeichnung:
anti-Obscurin Antikörper (OBSCN)
Auf www.antikoerper-online.de finden Sie aktuell 5 Obscurin (OBSCN) Antikörper von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Obscurin Proteine (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 7 Obscurin Produkte verfügbar.
Synonyme:
ARHGEF30, BC046431, Gm878, OTTMUSG00000005786, UNC89
Alle Antikörper anzeigen Gen GeneID UniProt
OBSCN 84033 Q5VST9
Anti-Maus OBSCN OBSCN 380698  

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Meistgesuchte Reaktivitäten zu anti-Obscurin (OBSCN) Antikörper

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anti-Human Antikörper:

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Am meisten referenzierte anti-Obscurin Antikörper

  1. Human Polyclonal OBSCN Primary Antibody für ELISA, WB - ABIN529547 : Hu, Kontrogianni-Konstantopoulos: The kinase domains of obscurin interact with intercellular adhesion proteins. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 (PubMed)

Weitere Antikörper gegen Obscurin Interaktionspartner

Human Obscurin (OBSCN) Interaktionspartner

  1. OBSCN mutations may result in the development of a familial dilated cardiomyopathy (DCM) phenotype via haploinsufficiency. These mutations should be considered as a significant causal factor of DCM, alone or in concert with other mutations.

  2. Gene-based association analyses shows nominal significant association with multifocal fibromuscular dysplasia for obscurin.

  3. Loss of the obscurin-RhoGEF downregulates RhoA (zeige RHOA Antikörper) signaling and increases microtentacle formation and attachment of breast epithelial cells.

  4. this study presents here the X-ray structure of the human titin:obscurin M10:O1 complex extending our previous work on the M10:OL1 interaction.

  5. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (zeige ANK1 Antikörper) (sAnk1.5) protein turnover

  6. OBSCN polymorphisms, in particular, highly conserved nonsynonymous Leu2116Phe variant, might contribute to aspirin hypersensitivity in asthmatics

  7. Results describe the molecular basis for the head-to-tail interaction of the carboxyl terminus of titin (zeige TTN Antikörper) and the amino-terminus of obscurin-like-1 (zeige OBSL1 Antikörper) by X-ray crystallography.

  8. Results suggest that obscurin binds small ankyrin 1 (zeige ANK1 Antikörper), and document a specific and direct interaction between proteins of the sarcomere and the sarcoplasmic reticulum.

  9. The complete gene giant muscle protein obscurin was analysed. The fusion of the conventional obscurin A, containing only the GEF (zeige SLC2A4RG Antikörper) domain, and obscurin B, fusing into the 3' kinase exons, was experimentally confirmed and analysed.

  10. OBSCN and C9orf65 (zeige PRUNE2 Antikörper) comprise a highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.

Mouse (Murine) Obscurin (OBSCN) Interaktionspartner

  1. Altogether, these results suggest that obscurin is required for the maintenance of morphological and ultrastructural integrity of skeletal muscle fibers against damage induced by intense mechanical stress and point to the diaphragm as the skeletal muscle most severely affected in obscurin-deficient mice.

  2. obscurins are not restricted to striated (zeige NSDHL Antikörper) muscles, but are abundantly expressed in several tissues and organs including brain, skin, kidney, liver, spleen, and lung.

  3. the obscurin kinase domains, SK1 (zeige SPHK1 Antikörper) and SK2 (zeige PAPSS2 Antikörper), are active enzymes with distinct substrate specificities.

  4. Obscurin, by targeting ankB (zeige ANKH Antikörper) at the M band, contributes to the organization of subsarcolemma microtubules, localization of dystrophin (zeige DMD Antikörper) at costameres, and maintenance of sarcolemmal integrity.

  5. Results support a role of obscurin in mediating the subcellular localization of small ankyrin1 isoforms in striated (zeige NSDHL Antikörper) muscle cells.

  6. the Rho-GEF (zeige ARHGEF2 Antikörper) domain of obscurin interacts with RanBP9 (zeige RANBP9 Antikörper) and that both can interact with the N-terminal region of titin (zeige TTN Antikörper) to influence the formation of the Z-disk and A/I junction

  7. ANK2 (zeige ANK2 Antikörper) is subject to alternative splicing that gives rise to unique polypeptides with diverse roles in cardiac function.

  8. the organization of obscurin at different locations in the sarcomere changes during muscle development and that this might affect the interaction with ank1.5.

Obscurin (OBSCN) Antigen-Profil

Beschreibung des Gens

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with Obscurin (OBSCN)

  • obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN) Antikörper
  • obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (Obscn) Antikörper
  • ARHGEF30 Antikörper
  • BC046431 Antikörper
  • Gm878 Antikörper
  • OTTMUSG00000005786 Antikörper
  • UNC89 Antikörper

Bezeichner auf Proteinebene für anti-Obscurin (OBSCN) Antikörper

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF , obscurin , obscurin, myosin light chain kinase , obscurin-MLCK , obscurin-RhoGEF , obscurin-myosin light chain kinase

GENE ID SPEZIES
420395 Gallus gallus
457798 Pan troglodytes
537193 Bos taurus
84033 Homo sapiens
380698 Mus musculus
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