Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.
Regulation of Oct4 (zeige POU5F1 Proteine) by SirT1 may link stem cell development to environmental conditions, and it may provide strategies to manipulate epiblast cell state.
a tissue-restricted isoform of SIRT1 (SIRT1-DeltaE2) that lacks exon 2 (E2), is reported.
Thus we concluded that the AMPKalpha (zeige GRK4 Proteine)-SIRT1 molecular pathway may be a molecular mechanism of IR in PCOS and may serve as a therapeutic target for the development of potential treatments for improving metabolic and reproductive function in PCOS.
SIRT1 knock-out embryos display reduced Mat2a (zeige MAT2A Proteine) expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 knock-out newborn mice.
The present study demonstrates that the aging heart is characterized by contractile dysfunction associated with increased oxidative stress and endoplasmic reticulum stress and Sirtuin 1 might have the ability to protect the aging hearts from the inhibition of endoplasmic reticulum-mediated apoptosis.
SIRT1 has the ability to effectively regulate the wear particle-induced inflammatory responses, apoptosis, osteolysis in particle-stimulated osteoblasts and particle-induced osteolysis animal models.
Taken together, our data indicated that increased expression of miR (zeige MLXIP Proteine)-181b potentially contributes to altered lipid metabolism in NAFLD. Downregulation of miR (zeige MLXIP Proteine)-34a may be a therapeutic strategy against NAFLD by regulating its target SIRT1.
data demonstrate that resveratrol requires neuronal SIRT1 to elicit ischemic tolerance and identify a novel role for SIRT1 in the regulation of glycolytic function in brain.
The Sirt7 (zeige SIRT7 Proteine) mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 (zeige DNMT1 Proteine) and another member of the sirtuin family, Sirt1.
findings reveal an unexpected mechanism for SIRT3 (zeige SIRT3 Proteine) regulation via SIRT1-mediated deacetylation. Improving mitochondrial SIRT3 (zeige SIRT3 Proteine) functions by inhibiting SIRT3 (zeige SIRT3 Proteine) acetylation may offer a new therapeutic approach for obesity- and aging-related diseases associated with mitochondrial dysfunction.
Data confirm that SIRT1 plays role in regulation of pre-rRNA synthesis/transcription and processing of RNA (specifically pre-rRNA and 28S rRNA); lysine acetylation stoichiometry is involved in gene expression regulation.
Long non-coding RNA HNF1A (zeige HNF1A Proteine)-AS1 (zeige PTGDR Proteine) mediated the metastatic progression of colon cancer in part through miR (zeige MLXIP Proteine)-34a/SIRT1/p53 (zeige TP53 Proteine) signaling axis.
Association between SIRT1 variation and pediatric obesity in Korean children with a gender difference.
The results suggested that inhibition of glycolysis using sub-lethal doses of 2-DG down-regulated the expression of VEGF (zeige VEGFA Proteine) and also significantly reduced its biological activity. Further mechanistic studies revealed that the down regulation of VEGF (zeige VEGFA Proteine) gene expression by 2-DG was due to an increase in SIRT-1 activity
The present results suggest that resveratrol and EPA, but not DHA, markedly activated the SIRT1 gene expression in THP1 cells, and that high glucose medium could inhibit the basic gene expression, but not powerful resveratrol-induced gene expression, in those cells.
Accordingly, our results demonstrated that NAMPT (zeige NAMPT Proteine) is a prognostic marker in melanoma, and the identificationofNAMPT-E2F2 (zeige E2F2 Proteine)-SIRT1 pathway establishes another link between NAMPT (zeige NAMPT Proteine) and apoptosis events in melanoma, with therapeutic implications for this deadly cancer.
These data suggest that SIRT1 activates HBG expression through facilitating LCR looping to the HBG promoter, inhibiting the expression of transcriptional suppressors of HBG, and indirectly increasing histone acetylation in the HBG promoter.
Levels of miR106a are modulated during cellular migration, causing a change in the levels of SIRT-1 mRNA by affecting its stability and the levels of SIRT-1 in turn can regulate the levels of MMP9 (zeige MMP9 Proteine).
Study demonstrated a functional role of the SIRT1/miR (zeige MLXIP Proteine)-15b-5p/ACOX1 (zeige ACOX1 Proteine) axis in CRC (zeige CALR Proteine) metastasis.
Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.
SIRT1, p53 (zeige TP53 Proteine) and NF-kappaB (zeige NFKB1 Proteine) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
the expression of SIRT1 is associated with the Mt number in oocytes
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (zeige PNPLA2 Proteine)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (zeige PPARG Proteine) to that of ATGL (zeige PNPLA2 Proteine) in adipocytes.
CDK5 (zeige CDK5 Proteine)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
SIRT1 and LKB1 (zeige STK11 Proteine)/AMPK (zeige PRKAA1 Proteine) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.
Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (zeige FOXO1 Proteine).
The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein
Downregulation of miR (zeige MYLIP Proteine)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Sirt1 regulates the expression of FABP3 (zeige FABP3 Proteine) gene in adipocytes, and PPAR gamma (zeige PPARG Proteine) apparently plays an important role in this process.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Downregulation of SIRT1 and FoxO1 (zeige FOXO1 Proteine) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.
Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.
5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits
The expression profile of sirtuin 1 and sirtuin 3 (zeige SIRT3 Proteine) in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
, NAD-dependent deacetylase sirtuin-1
, NAD-dependent protein deacetylase sirtuin-1
, SIR2-like protein 1
, regulatory protein SIR2 homolog 1
, sir2-like 1
, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
, sirtuin type 1
, sirtuin (silent mating type information regulation 2 homolog) 1
, NAD-dependent deacetylase sirtuin 1