SIRT1 Proteine (SIRT1)

Sirtuin 1 Proteine (SIRT1)
Auf finden Sie aktuell 18 Sirtuin 1 (SIRT1) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SIRT1 Antikörper (330) und SIRT1 Kits (44) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 399 SIRT1 Produkte verfügbar.
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
alle Proteine anzeigen Gen GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

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Am meisten referenzierte SIRT1 Proteine

  1. Human SIRT1 Protein expressed in Escherichia coli (E. coli) - ABIN2004752 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
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Weitere Proteine zu SIRT1 Interaktionspartnern

Rabbit Sirtuin 1 (SIRT1) Interaktionspartner

  1. Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.

  2. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) Interaktionspartner

  1. Sirt1 interacts with NF-kappa B (zeige NFKB1 Proteine) and PPAR alpha (zeige PPARA Proteine) to mediate the effects of the high-fat diet on the heart.

  2. SIRT1 regulated hepatocellular proliferation, circadian rhythms, and lipid metabolism during liver regeneration.

  3. Obesity-linked phosphorylation of SIRT1 inhibits its function and promotes pathological symptoms of nonalcoholic fatty liver disease. Ser-164 was identified as a major serine phosphorylation site in SIRT1 in obese, but not lean, mice, and this phosphorylation was catalyzed by casein kinase 2.

  4. SIRT1 promotes early-onset AHL (zeige CDH23 Proteine) through suppressing FOXO3a (zeige FOXO3 Proteine)-mediated oxidative stress resistance in the cochlea of C57BL/6 mice.

  5. In analyses of intestinal tissues, colitis induction, and gut (zeige GUSB Proteine) microbiota in mice with intestinal epithelial disruption of SIRT1, we found this protein to prevent intestinal inflammation by regulating the gut (zeige GUSB Proteine) microbiota.

  6. this study shows that SIRT1-dependent differentiation of Th9 cells confers protection against tumors and contributes to allergic airway inflammation

  7. SIRT1 interacts with and promotes the transactivation potential of RUNX2 (zeige RUNX2 Proteine).

  8. Sirt1 might be directly involved in spermiogenesis in germ cells but not in steroidogenic cells. Germ cell-specific Sirt1 knockout mice were almost completely infertile; the early mitotic and meiotic progression of germ cells in spermatogenesis were not obviously affected after Sirt1 depletion, but subsequent spermiogenesis was disrupted by a defect in acrosome biogenesis.

  9. Sirt1 significantly reduced the levels of raptor (zeige RPTOR Proteine) and inactivated mammalian target of rapamycin (mTOR (zeige FRAP1 Proteine))C1 signal by interacting with Akt2 (zeige AKT2 Proteine).

  10. These findings indicate that SIRT1 is a key regulator of macrophage self-renewal that integrates cell cycle and longevity pathways.

Human Sirtuin 1 (SIRT1) Interaktionspartner

  1. In cigarette smoke extract stimulated bronchial epithelial cells, carbocysteine increased cell proliferation, and SIRT1 and FoxO3 (zeige FOXO3 Proteine) nuclear expression, and reduced beta galactosidase (zeige GLB1 Proteine) and survivin (zeige BIRC5 Proteine) expression.

  2. O-GlcNAcylation is a central component linking metabolism to invasion and metastasis via an SIRT1/ERK (zeige EPHB2 Proteine)/FOXM1 (zeige FOXM1 Proteine) axis.

  3. Phosphorylated S164-SIRT1 and Casein Kinase 2 levels were also highly elevated in liver samples of nonalcoholic fatty liver disease patients and correlated with disease severity.

  4. Our data suggest that the p53 (zeige TP53 Proteine)-dependent, chemotherapeutics-induced cytotoxicity in cervical cancer cells may be compromised by catecholamines-induced upregulation of the Sirt1 expression through activating the beta2-adrenergic receptor (zeige ADRB2 Proteine) signaling

  5. Up-regulation of transcription factor DeltaNp63 led to the decline of miR (zeige MLXIP Proteine)-181a expression, resulting in an overexpression of the antiaging protein Sirt1, in CD4 (zeige CD4 Proteine)(+) T cells from HCV-infected individuals. Either reconstituting miR (zeige MLXIP Proteine)-181a or silencing DeltaNp63 or Sirt1 expression in CD4 (zeige CD4 Proteine)(+) T cells led to accelerated T cell senescence.

  6. data reveals that the pathway 'HULC/USP22 (zeige USP22 Proteine)/Sirt1/ protective autophagy' attenuates the sensitivity of hepatocellular carcinoma cells to chemotherapeutic agents, suggesting that this pathway may be a novel target for developing sensitizing strategy to hepatocellular carcinoma chemotherapy

  7. SIRT1 plays a key role in the inflammatory response in aseptic loosening through NF-kappaB (zeige NFKB1 Proteine) deacetylation .

  8. The tumor-associated NADH oxidase (tNOX (zeige ENOX2 Proteine))-mediated modulation of the NAD+ concentration and SIRT1 are involved in oxaliplatin-induced apoptosis.

  9. Up-regulated SIRT1 expression may serve as a potential biomarker for predicting the progression of cervical squamous intraepithelial lesions to invasive squamous cell carcinoma.

  10. Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F (zeige HNRNPF Proteine), SIRTUIN-1, and FOXO3alpha than nondiabetic kidneys.

Pig (Porcine) Sirtuin 1 (SIRT1) Interaktionspartner

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (zeige TP53 Proteine) and NF-kappaB (zeige NFKB1 Proteine) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (zeige PNPLA2 Proteine)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (zeige PPARG Proteine) to that of ATGL (zeige PNPLA2 Proteine) in adipocytes.

  5. CDK5 (zeige CDK5 Proteine)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (zeige STK11 Proteine)/AMPK (zeige PRKAA1 Proteine) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (zeige FOXO1 Proteine).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (zeige MYLIP Proteine)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (zeige FABP3 Proteine) gene in adipocytes, and PPAR gamma (zeige PPARG Proteine) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) Interaktionspartner

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (zeige FOXO1 Proteine) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (zeige SIRT3 Proteine) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1)
  • sirtuin 1 (SRT1)
  • sirtuin 1 (LOC100349271)
  • sirtuin 1 (Sirt1)
  • sirtuin 1 (sirt1)
  • AA673258 Protein
  • SIR2 Protein
  • Sir2a Protein
  • Sir2alpha Protein
  • sir2l1 Protein
  • sirtuin Protein
  • sirtuin 1 Protein

Bezeichner auf Proteinebene für Sirtuin 1 Proteine (SIRT1)

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
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