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SIRT1 Proteine (SIRT1)

Bezeichnung:
Sirtuin 1 Proteine (SIRT1)
Auf www.antikoerper-online.de finden Sie aktuell 18 Sirtuin 1 (SIRT1) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SIRT1 Antikörper (308) und SIRT1 Kits (44) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 377 SIRT1 Produkte verfügbar.
Synonyme:
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
alle Proteine anzeigen Gen GeneID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  

Weitere Synonyme anzeigen

SIRT1 Proteine (SIRT1) nach Spezies

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Am meisten referenzierte SIRT1 Proteine

  1. Human SIRT1 Protein expressed in Escherichia coli (E. coli) - ABIN2004752 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
    Zeige alle 5 Referenzen für ABIN2004752

Weitere Proteine zu SIRT1 Interaktionspartnern

Rabbit Sirtuin 1 (SIRT1) Interaktionspartner

  1. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) Interaktionspartner

  1. Lung fibroblasts deficient in Sirt1 or treated with a selective Sirt1 inhibitor exhibit increased cellular senescence and decreased TPP1 (zeige TPP1 Proteine) levels, whereas Sirt1 overexpression and pharmacological activation protect against CS-induced TPP1 (zeige TPP1 Proteine) reduction and telomeric DNA damage.

  2. this study shows that the expression of SIRT1 is decreased in sepsis; SIRT1 functions as a negative regulator of pro-inflammatory cytokines

  3. Hepatic G6Pase-alpha (zeige G6PC Proteine) deficiency leads to reduced expression of SIRT1. Downregulation of SIRT1 signaling impairs autophagy.

  4. AMPK (zeige PRKAA1 Proteine) phosphorylation of cortactin (zeige CTTN Proteine) followed by SIRT1 deacetylation modulates the interaction of cortactin (zeige CTTN Proteine) and cortical-actin in response to shear stress. Functionally, this AMPK (zeige PRKAA1 Proteine)/SIRT1 coregulated cortactin (zeige CTTN Proteine)-F-actin dynamics is required for endothelial nitric oxide synthase (zeige NOS3 Proteine) subcellular translocation/activation and is atheroprotective

  5. Activation of alpha7nAChR alleviates Ang II (zeige AGT Proteine)-induced vascular smooth muscle cell senescence by promoting NAD(+)-SIRT1 pathway.

  6. data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1 (zeige SP1 Proteine)/SIRT1 signaling pathway.

  7. Hyperglycemia and elevated free fatty acids in the diabetic milieu recruit p66Shc (zeige SHC1 Proteine) to upregulate endothelial miR (zeige MLXIP Proteine)-34a via an oxidant-sensitive mechanism, which leads to endothelial dysfunction by targeting Sirt1.

  8. Data demonstrate that CLOCK and BMAL1 (zeige ARNTL Proteine) regulate muscle insulin (zeige INS Proteine) sensitivity via SIRT1, and activation of SIRT1 might be a potential valuable strategy to attenuate muscle insulin (zeige INS Proteine) resistance related to circadian misalignment.

  9. NAMPT (zeige NAMPT Proteine) inhibited endothelial progenitor cell senescence through an SIRT1 AS lncRNA/miR (zeige MLXIP Proteine)-22/SIRT1 pathway

  10. this study shows that fisetin exerts anti-inflammatory effects and attenuates the progression of osteoarthritis through activating SIRT1

Human Sirtuin 1 (SIRT1) Interaktionspartner

  1. in chronic hyperoxia, SIRT1 promotes hyperoxia-induced lung epithelial cell damage and death by altering pro- and antiapoptotic balance, not by dampening optimal NRF2 (zeige GABPA Proteine)-dependent antioxidant enxyme expression.

  2. Lung fibroblasts deficient in Sirt1 or treated with a selective Sirt1 inhibitor exhibit increased cellular senescence and decreased TPP1 (zeige TPP1 Proteine) levels, whereas Sirt1 overexpression and pharmacological activation protect against CS-induced TPP1 (zeige TPP1 Proteine) reduction and telomeric DNA damage.

  3. our results showed that the expression and activity of SIRT1 are decreased in PASMCs exposed to H/R.

  4. Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a (zeige FOXO3 Proteine)/EGR1 (zeige EGR1 Proteine)/SIRT1 signaling, and AKT (zeige AKT1 Proteine) and p300 (zeige EP300 Proteine) negatively regulate this process via Bim (zeige BCL2L11 Proteine) upregulation.

  5. AMPK (zeige PRKAA1 Proteine) phosphorylation of cortactin (zeige CTTN Proteine) followed by SIRT1 deacetylation modulates the interaction of cortactin (zeige CTTN Proteine) and cortical-actin in response to shear stress. Functionally, this AMPK (zeige PRKAA1 Proteine)/SIRT1 coregulated cortactin (zeige CTTN Proteine)-F-actin dynamics is required for endothelial nitric oxide synthase (zeige NOS3 Proteine) subcellular translocation/activation and is atheroprotective

  6. Activation of alpha7nAChR alleviates Ang II (zeige AGT Proteine)-induced vascular smooth muscle cell senescence by promoting NAD(+)-SIRT1 pathway.

  7. Structural features important for SIRT1 activation.

  8. SIRT1 predominantly localizes to the nucleus in cancer cells.

  9. A potential mechanism for the role of Sirt1 in lung fibrosis was through regulating the expression of p300 (zeige EP300 Proteine). Thus, we characterized Sirt1 as an important regulator of lung fibrosis and provides a proof of principle for activation or overexpression of Sirt1 as a potential novel therapeutic strategy for IPF.

  10. the interplay between SIRT1 and HBx in the activation of hepatitis b virus transcription, is reported.

Pig (Porcine) Sirtuin 1 (SIRT1) Interaktionspartner

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (zeige TP53 Proteine) and NF-kappaB (zeige NFKB1 Proteine) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (zeige PNPLA2 Proteine)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (zeige PPARG Proteine) to that of ATGL (zeige PNPLA2 Proteine) in adipocytes.

  5. CDK5 (zeige CDK5 Proteine)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (zeige STK11 Proteine)/AMPK (zeige PRKAA1 Proteine) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (zeige FOXO1 Proteine).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (zeige MYLIP Proteine)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (zeige FABP3 Proteine) gene in adipocytes, and PPAR gamma (zeige PPARG Proteine) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) Interaktionspartner

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (zeige FOXO1 Proteine) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (zeige SIRT3 Proteine) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1)
  • sirtuin 1 (SRT1)
  • sirtuin 1 (LOC100349271)
  • sirtuin 1 (Sirt1)
  • sirtuin 1 (sirt1)
  • AA673258 Protein
  • SIR2 Protein
  • Sir2a Protein
  • Sir2alpha Protein
  • sir2l1 Protein
  • sirtuin Protein
  • sirtuin 1 Protein

Bezeichner auf Proteinebene für Sirtuin 1 Proteine (SIRT1)

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

GENE ID SPEZIES
100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
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