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Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.
SIRT1 physically interacts with and deacetylates eIF2alpha (zeige EIF2A Proteine) and is a novel regulatory mechanism for protecting cardiac cells from endoplasmic reticulum stress.
Findings indicate that protein inhibitor of activated STAT 4 (PIAS4 (zeige PIAS4 Proteine)) mediated SIRT1 repression in response to nutrient surplus contributes to the pathogenesis of Nonalcoholic Steatohepatitis (NASH (zeige SAMSN1 Proteine)).
Berberine could attenuate oxidative stress of diabetic mice at least partly through miR (zeige MLXIP Proteine)-106b/SIRT1 pathway and affecting the function of islets, which might be beneficial in reducing the cardiovascular risk factors in diabetes.
ATGL (zeige PNPLA2 Proteine) acts as an important upstream signaling node that, via SIRT1, increases autophagy/lipophagy as a means to promote hepatic lipid droplet catabolism.
this study reveals a novel function of Vav1 (zeige VAV1 Proteine) in regulating mesenchymal stem cell fate decisions for differentiation through Sirt1.
The Sirt1 protein suppressed transcription of Dnmt3l (zeige TRDMT1 Proteine).
Cav-1 (zeige CAV1 Proteine) deficiency induces premature senescence via mitochondrial dysfunction and SIRT1 inactivation.
Regulation of Oct4 (zeige POU5F1 Proteine) by SirT1 may link stem cell development to environmental conditions, and it may provide strategies to manipulate epiblast cell state.
a tissue-restricted isoform of SIRT1 (SIRT1-DeltaE2) that lacks exon 2 (E2), is reported.
Thus we concluded that the AMPKalpha (zeige GRK4 Proteine)-SIRT1 molecular pathway may be a molecular mechanism of IR in PCOS and may serve as a therapeutic target for the development of potential treatments for improving metabolic and reproductive function in PCOS.
Our findings clearly evidenced a novel and negative role of miR (zeige MLXIP Proteine)-199b in the regulation of SIRT1 in colorectal cancer cells
We found a negative correlation between mRNA levels of SIRT1 in VAT of obese individuals and SIRT7 (zeige SIRT7 Proteine) in VAT of the normal-weight subjects and expression of the relevant miRNAs.
SIRT1 activation induces STAT3 (zeige STAT3 Proteine) deacetylation, reducing its ability to translocate into the nucleus, bind to Rorc (zeige RORC Proteine) promoter, and induce its transcription.
SIRT1 regulates inflammation by inhibiting NF-kappaB (zeige NFKB1 Proteine) during monocyte differentiation.
These findings reveal the involvement of SIRT1 in hepatocellular carcinoma metastasis
Our study shows that SIRT1 is a pro-survival protein that is downregulated under cellular stress.
These data provide the first evidence of the Egt ability to interfere with endothelial senescence linked to hyperglycaemia through the regulation of SIRT1 and SIRT6 (zeige SIRT6 Proteine) signaling, thus further strengthening the already assessed role of these two histone deacetylases in type 2 diabetes.
DDOST (zeige DDOST Proteine) and SIRT1 are differently expressed in peripheral blood mononuclear cells from type 1 diabetes patients with and without microvascular complications. Their expression is also influenced by dietary advanced glycation end-products and by statins and angiotensin receptor blockers.
High SIRT1 expression is associated with malignant pleural mesothelioma.
Data show that Sirt1 mRNA was negatively correlated with miR (zeige MLXIP Proteine)-133b level in tumor tissue.
Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.
SIRT1, p53 (zeige TP53 Proteine) and NF-kappaB (zeige NFKB1 Proteine) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
the expression of SIRT1 is associated with the Mt number in oocytes
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (zeige PNPLA2 Proteine)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (zeige PPARG Proteine) to that of ATGL (zeige PNPLA2 Proteine) in adipocytes.
CDK5 (zeige CDK5 Proteine)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
SIRT1 and LKB1 (zeige STK11 Proteine)/AMPK (zeige PRKAA1 Proteine) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.
Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (zeige FOXO1 Proteine).
The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein
Downregulation of miR (zeige MYLIP Proteine)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Sirt1 regulates the expression of FABP3 (zeige FABP3 Proteine) gene in adipocytes, and PPAR gamma (zeige PPARG Proteine) apparently plays an important role in this process.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Downregulation of SIRT1 and FoxO1 (zeige FOXO1 Proteine) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.
Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.
5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits
The expression profile of sirtuin 1 and sirtuin 3 (zeige SIRT3 Proteine) in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
, NAD-dependent deacetylase sirtuin-1
, NAD-dependent protein deacetylase sirtuin-1
, SIR2-like protein 1
, regulatory protein SIR2 homolog 1
, sir2-like 1
, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
, sirtuin type 1
, sirtuin (silent mating type information regulation 2 homolog) 1
, NAD-dependent deacetylase sirtuin 1