anti-MKNK2 (MKNK2) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 88 MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) Antikörper von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MKNK2 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 108 MKNK2 Produkte verfügbar.
Synonyme:
2010016G11Rik, Gprk7, mknk2, Mnk2, wu:fb37e05, wz5090
Alle Antikörper anzeigen Gen GeneID UniProt
MKNK2 2872 Q9HBH9
MKNK2 17347 Q8CDB0
MKNK2 299618 Q5U2N4

Meistgesuchte Reaktivitäten zu anti-MKNK2 (MKNK2) Antikörper

anti-Human MKNK2 Antikörper:

anti-Mouse (Murine) MKNK2 Antikörper:

anti-Rat (Rattus) MKNK2 Antikörper:

Alle verfügbaren anti-MKNK2 Antikörper

Sie gelangen zu unserer vorgefilterten Suche.

Weitere Antikörper gegen MKNK2 Interaktionspartner

Human MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) Interaktionspartner

  1. Data show that galeterone (gal (zeige GAL Antikörper)) and VNPT55 inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression via antagonizing the Mnk1 (zeige MKNK1 Antikörper)/2-eIF4E (zeige EIF4E Antikörper) axis.

  2. Data suggest MNK1 (zeige MKNK1 Antikörper)/MNK2 stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (zeige EIF4E Antikörper) (via decreased binding to eIF4G (zeige EIF4G1 Antikörper)).

  3. MNK1 (zeige MKNK1 Antikörper) and MNK2 inhibition ablates eIF4E1 (zeige EIF4E Antikörper) phosphorylation and concurrently enhances eIF4E3 (zeige EIF4E3 Antikörper) expression in diffuse large B-cell lymphoma.

  4. Data show that interferon-gamma (zeige IFNG Antikörper) regulated the metabolism and mRNA translation of macrophages by targeting the kinases mTORC1 and MNK1 (zeige MKNK1 Antikörper)/2, both of which converge on the selective regulator of translation initiation eukaryotic initiation factor-4E (eIF4E (zeige EIF4E Antikörper)).

  5. Provide evidence for the existence of a Mnk2/eIF4E (zeige EIF4E Antikörper)-controlled feedback loop in medulloblastoma cells that accounts for resistance to mTORC1 inhibitors.

  6. Data suggest that a combined pharmacologic inhibition of mTORC1 and Mnk1/2 kinases offers a therapeutic opportunity in blast crisis-chronic myeloid leukemia (BC-CML).

  7. These findings provide evidence for key and essential roles of the Mnk kinase pathway in the generation of the antineoplastic effects of type I IFNs in Jak2V617F-dependent myeloproliferative neoplasms.

  8. eIF4E (zeige EIF4E Antikörper) phosphorylation is enhanced by Rapamycin, which activates Mnk2a

  9. MNK2-dependent phosphorylation of eIF4E (zeige EIF4E Antikörper) represents a novel drug resistance, pro-survival pathway in pancreatic ductal carcinoma.

  10. siRNA-mediated Mnk1 (zeige MKNK1 Antikörper)/2 knockdown results in partial reversal of the suppressive effects of IFNgamma on human CD34 (zeige CD34 Antikörper)+-derived myeloid (CFU-GM) and erythroid (BFU-E) progenitors.

Mouse (Murine) MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) Interaktionspartner

  1. MNK2 plays a role in adipogenesis and/or lipogenesis and in macrophage biology

  2. Data suggest that Mnk1 (zeige MKNK1 Antikörper) and Mnk2 regulate cell migration/wound healing, expression of vimentin (zeige VIM Antikörper), stability of vimentin (zeige VIM Antikörper) protein, and binding of eIF4E (eukaryotic translation initiation factor 4E (zeige EIF4E Antikörper)) and Cyfip1 (cytoplasmic FMR1 interacting protein 1 (zeige CYFIP1 Antikörper)).

  3. Mnk2a directly interacts with and translocates p38alpha (zeige MAPK14 Antikörper)-MAPK (zeige MAPK1 Antikörper) into the nucleus. Alternatively, Mnk2b does not activate p38-MAPK (zeige MAPK14 Antikörper).

  4. eIF4E (zeige EIF4E Antikörper) phosphorylation is enhanced by Rapamycin, which activates Mnk2a

  5. Mnk1 (zeige MKNK1 Antikörper)/2 has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 (zeige HAND1 Antikörper) and Th17 differentiation in vivo.

  6. Data indicate that MNK2 plays a unique role, not shared by its closest paralog MNK1 (zeige MKNK1 Antikörper), in limiting protein translation through its negative effect on eIF4G (zeige EIF4G1 Antikörper) Ser1108 phosphorylation and p70S6K (zeige RPS6KB1 Antikörper) activation.

  7. MAP kinase (zeige MAPK1 Antikörper)-interacting kinase 1 and 2 activity enhances formation of the EIF-4F complex in pachytene spermatocytes but not in round spermatids.

  8. oncogenic role for Mnk1 (zeige MKNK1 Antikörper)/2 in tumor development

  9. Mnk2 and Mnk1 (zeige MKNK1 Antikörper) are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E (zeige EIF4EBP2 Antikörper) but not for cell growth or development

  10. The roles of features in the catalytic domains and C termini in determining the regulatory properties and basal activities of Mnk1 (zeige MKNK1 Antikörper) AND Mnk2 are reported.

MKNK2 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization.

Alternative names and synonyms associated with MKNK2

  • MAP kinase interacting serine/threonine kinase 2 (MKNK2) Antikörper
  • MAP kinase interacting serine/threonine kinase 2 (mknk2) Antikörper
  • MAP kinase-interacting serine/threonine kinase 2 (Mknk2) Antikörper
  • MAP kinase-interacting serine/threonine kinase 2b (mknk2b) Antikörper
  • 2010016G11Rik Antikörper
  • Gprk7 Antikörper
  • mknk2 Antikörper
  • Mnk2 Antikörper
  • wu:fb37e05 Antikörper
  • wz5090 Antikörper

Bezeichner auf Proteinebene für MKNK2

MAP kinase interacting serine/threonine kinase 2 , MAP kinase-interacting serine/threonine kinase 2 , MAP kinase signal-integrating kinase 2 , MAP kinase-interacting serine/threonine-protein kinase 2 , MAPK signal-integrating kinase 2 , G protein-coupled receptor kinase 7 , mnk2

GENE ID SPEZIES
429269 Gallus gallus
455561 Pan troglodytes
780232 Xenopus (Silurana) tropicalis
100517077 Sus scrofa
2872 Homo sapiens
399068 Xenopus laevis
612212 Canis lupus familiaris
538519 Bos taurus
17347 Mus musculus
299618 Rattus norvegicus
373121 Danio rerio
Ausgewählte Anbieter für anti-MKNK2 (MKNK2) Antikörper
Haben Sie etwas anderes gesucht?