anti-GJA1 (GJA1) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 311 Gap Junction Protein, alpha 1, 43kDa (GJA1) Antikörper von 30 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GJA1 Kits (65) und GJA1 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 400 GJA1 Produkte verfügbar.
Synonyme:
AI118175, AU042049, AVSD3, AW546267, Cnx32, Cnx43, Cnx46, connexin43, connexin 43, Cx32, CX43, cx43a1, Cx43alpha1, Cx46, DFNB38, Gja-1, Gja-3, gja1, gja1-A, GJAL, Gjb-1, HLHS1, HSS, Npm1, ODDD, zfCx43.3
Alle Antikörper anzeigen Gen GeneID UniProt
GJA1 14609 P23242
Anti-Ratte GJA1 GJA1 24392 P08050
GJA1 2697 P17302

Meistgesuchte Reaktivitäten zu anti-GJA1 (GJA1) Antikörper

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Weitere Antikörper gegen GJA1 Interaktionspartner

Zebrafish Gap Junction Protein, alpha 1, 43kDa (GJA1) Interaktionspartner

  1. Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.

  2. serpinh1b (zeige HSP47 Antikörper) is molecularly and functionally downstream of cx43. The gene serpinh1b (zeige HSP47 Antikörper) codes for a protein called Hsp47 (zeige HSP47 Antikörper), a molecular chaperone (zeige HSP90AA1 Antikörper) responsible for proper folding of procollagen molecules.

  3. Hapln1a (zeige HAPLN1 Antikörper)-ECM (zeige MMRN1 Antikörper) stabilizes the secreted growth factor (zeige WNT2 Antikörper) Semaphorin3d (Sema3d (zeige SEMA3D Antikörper)), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.

  4. Hapln1a (zeige HAPLN1 Antikörper) has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton

  5. Sema3d (zeige SEMA3D Antikörper) functions in a common molecular pathway with Cx43 cell proliferation and joint formation

  6. Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL (zeige COL6A1 Antikörper)) exhibited osteogenic characteristics, in which Cx43 played an important role.

  7. Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.

  8. Data demonstrate a cross-talk between IGF-1R (zeige IGF1R Antikörper) and AT-1R in AT-II and IGF-1 (zeige IGF1 Antikörper)-induced Cx43 expression in SV SMCs involving Erk 1 (zeige MAPK3 Antikörper)/2 and downstream activation of the AP-1 (zeige JUN Antikörper) transcription factor.

  9. Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45 (zeige GJC1 Antikörper).

  10. Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.

Rabbit Gap Junction Protein, alpha 1, 43kDa (GJA1) Interaktionspartner

  1. These findings indicated that Cx43/miR (zeige MYLIP Antikörper)-206 is involved in the pathogenesis of early stage steroid-induced avascular necrosis of the femoral head.

  2. Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.

  3. Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.

  4. In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart

Mouse (Murine) Gap Junction Protein, alpha 1, 43kDa (GJA1) Interaktionspartner

  1. Activation of WNT/b-catenin activity improved cardiac contractility and ameliorated intraventricular conduction defects in LmnaH222P/H222P mice, which was associated with increased expression of myocardial connexin 43. These results indicate that decreased WNT/b-catenin contributes to the pathophysiology of LMNA cardiomyopathy and that drugs activating b-catenin may be beneficial in affected individuals

  2. These findings imply that enteric glia activation via Cx43 and P2X receptors is a significant modulator of morphine-related inflammation and constipation.

  3. Lower expression of connexin43 in vascular cells contributes to impaired vasomotor control in experimental diabetes.

  4. Blocking of connexin32 (zeige GJB1 Antikörper) or connexin43 hemichannels decreased serum levels of pro-inflammatory cytokines, and reduced acetaminophen-induced liver injury.

  5. deletion of connexin 43 (Cx43, also known as GJA1) in astrocytes inhibits OPC proliferation by decreasing matrix glucose levels without impacting on OPC hemichannel properties, a process that also occurs in corpus callosum from acute brain slices.

  6. Relative to Gja1(+/-) controls, male Gja1(-/K258Stop) mice have a cortical bone phenotype that is remarkably similar to those reported for deletion of the entire Cx43 gene in osteoblasts.

  7. S368 of connexin 43 (also known as GJA1) is phosphorylated on gap junctions and connexosomes, whereas connexin 43 residue S262 is phosphorylated only on some connexosomes.

  8. a plaque accretion defect as the primary manifestation of myosin VI (zeige MYO6 Antikörper) loss in Cx43 homeostasis, is reported.

  9. Findings demonstrate that spinal cord injury activates astrocyte sigma-1 receptors leading to increases in the expression of the gap junction protein, connexin 43 and astrocyte activation in the lumbar dorsal horn, and ultimately contribute to the induction of bilateral below-level mechanical allodynia.

  10. beige (zeige LYST Antikörper) adipocytes display an increased cell-to-cell coupling via connexin 43 (Cx43) gap junction channels.

Guinea Pig Gap Junction Protein, alpha 1, 43kDa (GJA1) Interaktionspartner

  1. The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.

  2. CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.

Cow (Bovine) Gap Junction Protein, alpha 1, 43kDa (GJA1) Interaktionspartner

  1. This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.

  2. Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.

  3. RhoA (zeige RHOA Antikörper) appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress

  4. Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.

  5. Human TGF-beta1 (zeige TGFB1 Antikörper) induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells

  6. Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.

  7. intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (zeige GJB2 Antikörper), Cx32 (zeige GJB1 Antikörper), and Cx43

  8. CBN (zeige CALB1 Antikörper) blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.

  9. Results describe the effect of suppression of connexin 43 and E-cadherin (zeige CDH1 Antikörper) on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.

Human Gap Junction Protein, alpha 1, 43kDa (GJA1) Interaktionspartner

  1. Cx45 (zeige GJC1 Antikörper) mutant p.R75H is responsible for a novel disease entity of progressive atrial conduction system defects associated with craniofacial and dentodigital malformation.

  2. Connexin 43 expression is increased in human fetal membrane defects after fetoscopic surgery compared to controls, with preferential distribution in the fibroblast layer compared with the epithelial layer.

  3. Results show stark differences in gap junction plaque formation, gap junctional intercellular communication, Cx43 phosphorylation, and hemichannel activity among Cx43 variants, as well as subtle differences in myofibroblast differentiation.

  4. These observations point to Cx43 as a novel profibrotic factor in asthma progression.

  5. results show that Cx43 expression is reduced in the diabetic retinas and Cx43 reduction is associated with increased vascular cell death; findings suggest that diabetes decreases retinal Cx43 expression and that the development of pericyte loss and acellular capilaries is associated with reduced Cx43 expression in diabetic retinopathy

  6. Reduced expression of Cx26 (zeige GJB2 Antikörper) and Cx43 is implicated in the pathophysiology of colonic dysmotility in the aganglionic bowel as well as, in the case of Cx26 (zeige GJB2 Antikörper), the ganglionic bowel in Hirschsprung's disease.

  7. Results suggest polymorphisms of Cx37 (zeige GJA4 Antikörper) rs1630310 and Cx43 rs1925223 genes may be associated with the pathogenesis of essential hypertension.

  8. The Cx43 is the most prominent gap junction protein in the heart, cardiomyocyte-differentiated stem cells have been studied intensely. Cx43 expression was detected at mRNA and protein level in human cord-blood-derived induced pluripotent stem cells .

  9. Human deltoid muscle biopsies of 5 Chilean dysferlinopathy patients exhibited the presence of muscular connexins (Cx40.1, Cx43 and Cx45 (zeige GJC1 Antikörper)).

  10. endogenous osteocyte Cx43 hemichannels emerge as important and promising therapeutic targets for the prevention of bone metastases and/or clinical treatment of bone-metastasized breast cancers

Pig (Porcine) Gap Junction Protein, alpha 1, 43kDa (GJA1) Interaktionspartner

  1. Data show that connexin 43 (Cx43) is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.

  2. The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.

  3. we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.

  4. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 (zeige CDK4 Antikörper) gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

  5. Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.

  6. Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.

  7. These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.

  8. Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.

  9. Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.

  10. During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.

GJA1 Antigen-Profil

Beschreibung des Gens

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.

Alternative names and synonyms associated with GJA1

  • gap junction protein, alpha 1, 43kDa (gja1) Antikörper
  • connexin 43 (cx43) Antikörper
  • connexin 43 (CX43) Antikörper
  • CONNEXIN 43 protein (CONNEXIN 43) Antikörper
  • connexin 43-like (LOC100359132) Antikörper
  • gap junction protein, alpha 1 (Gja1) Antikörper
  • gap junction protein, alpha 1, 43kDa (GJA1) Antikörper
  • gap junction protein, alpha 3 (Gja3) Antikörper
  • gap junction protein, beta 1 (Gjb1) Antikörper
  • AI118175 Antikörper
  • AU042049 Antikörper
  • AVSD3 Antikörper
  • AW546267 Antikörper
  • Cnx32 Antikörper
  • Cnx43 Antikörper
  • Cnx46 Antikörper
  • connexin43 Antikörper
  • connexin 43 Antikörper
  • Cx32 Antikörper
  • CX43 Antikörper
  • cx43a1 Antikörper
  • Cx43alpha1 Antikörper
  • Cx46 Antikörper
  • DFNB38 Antikörper
  • Gja-1 Antikörper
  • Gja-3 Antikörper
  • gja1 Antikörper
  • gja1-A Antikörper
  • GJAL Antikörper
  • Gjb-1 Antikörper
  • HLHS1 Antikörper
  • HSS Antikörper
  • Npm1 Antikörper
  • ODDD Antikörper
  • zfCx43.3 Antikörper

Bezeichner auf Proteinebene für GJA1

alpha 1 gap junction protein , connexin 43 , connexin-43 , etID309742.9 , gap junction alpha-1 protein , gap junction protein, alpha 1 , shf , short fin protein , sof , alpha 1 connexin , gap junction 43 kDa heart protein , gap junction membrane channel protein alpha 1 , cx43 , gap junction protein, alpha 1, 43 kD (connexin 43) , vascular smooth muscle connexin-43 , gap junction protein, alpha 1, 43kDa (connexin 43) , Connexin-43 , gap junction protein alpha 1 , gap junction protein, alpha 1, 43kDa , alpha 3 connexin , connexin-46 , gap junction alpha-3 protein , gap junction membrane channel protein alpha 3 , connexin 32 , connexin-32 , gap junction beta-1 protein , gap junction membrane channel protein beta 1

GENE ID SPEZIES
394450 Xenopus (Silurana) tropicalis
30236 Danio rerio
100067229 Equus caballus
443455 Ovis aries
100359132 Oryctolagus cuniculus
14609 Mus musculus
24392 Rattus norvegicus
100379273 Cavia porcellus
281193 Bos taurus
2697 Homo sapiens
403418 Canis lupus familiaris
100518636 Sus scrofa
100008935 Oryctolagus cuniculus
373664 Xenopus laevis
395278 Gallus gallus
443233 Ovis aries
101100211 Felis catus
14611 Mus musculus
14618 Mus musculus
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