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anti-Human GJA1 Antikörper:
anti-Rat (Rattus) GJA1 Antikörper:
anti-Mouse (Murine) GJA1 Antikörper:
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Chicken Monoclonal GJA1 Primary Antibody für IHC (f), IF - ABIN967717
Giepmans, Hengeveld, Postma, Moolenaar: Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. in The Journal of biological chemistry 2001
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Chicken Monoclonal GJA1 Primary Antibody für IHC (f), IF - ABIN967718
Loo, Berestecky, Kanemitsu, Lau: pp60src-mediated phosphorylation of connexin 43, a gap junction protein. in The Journal of biological chemistry 1995
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Human Polyclonal GJA1 Primary Antibody für IHC - ABIN965918
Solan, Fry, TenBroek, Lampe: Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation. in Journal of cell science 2003
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Human Polyclonal GJA1 Primary Antibody für IHC (p), WB - ABIN388369
Li, Zhang, Jiao, Zou: Knockdown of microRNA-181 by lentivirus mediated siRNA expression vector decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction. in Microvascular research 2009
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Human Polyclonal GJA1 Primary Antibody für IHC (p), WB - ABIN3043758
Peng, Dai, Ji, Dai: The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol. in European journal of pharmacology 2010
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Human Polyclonal GJA1 Primary Antibody für ICC, IHC (fro) - ABIN5518645
Li, Tang, Liang, Li, Wang, Song, Zheng, Xi, Zhang, Hescheler, Zhu: Coculture of embryonic ventricular myocytes and mouse embryonic stem cell enhance intercellular signaling by upregulation of connexin43. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2013
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Human GJA1 Primary Antibody für IHC - ABIN965917
Matsushita, Kurihara, Watanabe, Okada, Sakai, Amano: Alterations of phosphorylation state of connexin 43 during hypoxia and reoxygenation are associated with cardiac function. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006
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Dog (Canine) Polyclonal GJA1 Primary Antibody für IF (p), IHC (p) - ABIN671451
Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014
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Chicken Polyclonal GJA1 Primary Antibody für WB - ABIN2473077
Donovan: Indomethacin, ketoprofen and corpus luteum regression in the guinea-pig. in British journal of pharmacology 1975
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Bird (Avian) Polyclonal GJA1 Primary Antibody für WB - ABIN152643
Sahin, Akdemir, Tuzcu, Sahin, Onderci, Ozercan, Ilhan, Kilic, Seren, Kucuk: Genistein suppresses spontaneous oviduct tumorigenesis in quail. in Nutrition and cancer 2010
Data show that Cx43 was inhibited predominantly via IL-1beta (zeige IL1B Antikörper)-activated ERK1/2 (zeige MAPK1/3 Antikörper) and p38 MAP kinase (zeige MAPK14 Antikörper) cascades.
BMP2 (zeige BMP2 Antikörper) decreases gap junction intercellular communication of luteinized human granulosa cells by downregulating Cx43 expression through an ALK2 (zeige ACRV1 Antikörper)/ALK3 (zeige BMPR1A Antikörper)-mediated SMAD (zeige SMAD1 Antikörper)-dependent signaling pathway.
NO controls the calcium signal propagation through Cx37-containing gap junctions. The tyrosine phosphatase SHP-2 is the essential mediator and NO target.
Taking into account that connexin-43 (Cx43) (together with Cx30 (zeige GJB6 Antikörper)) is heavily expressed in astrocytes and that drebrin (zeige DBN1 Antikörper) supports cell-cell contacts, the understanding of details of how brain cells live and die reveals molecular pathology involved in neurodegeneration, Alzheimer's disease (AD), other cognitive disorders, and aging
at gap junctions drebrin (zeige DBN1 Antikörper) interacts with connexin 43, stabilizes this protein at membranes, and links it to the actin cytoskeleton. In vivo drebrin (zeige DBN1 Antikörper) is widespread in diverse non-neuronal tissues of epithelial, endothelial, and smooth muscle origin, but not ubiquitous.
These results suggested that the AKT (zeige AKT1 Antikörper) pathway was the dominant pathway involved in Cx43-mediated chronic cadmium toxicity.
Gap junctional intercellular communication mediated by the Cx43 channels plays a central role throughout the differentiation of bone marrow stromal cells into osteoblasts, from the early stages to the process of mineralization.
Study identify a role for Cx43 formed gap junction channels in the regulation of T lymphocyte proliferation and pro-inflammatory cytokines release during hypertension.
The article findings propose a novel, lactate-handling role for Cx43 (GJA1 gene) which may be particularly critical in acidotic regions of tumours.
We conclude that the targeted action of JM2 (zeige FOXP3 Antikörper) on Cx43 channels may improve the tolerance of implanted tissue-engineered constructs against the innate inflammatory response.
the presence of the C-terminal domain of Cx43 in osteocytes and other cell types is important to maintain normal structure and mechanical integrity of bone.
The astroglial targeted connexin43 gene knocking-out in APPswe/PS1dE9 mice allowed to diminish gliotransmitter release and to alleviate neuronal damages, reducing oxidative stress and neuritic dystrophies in hippocampal neurons associated to plaques.
Thus we propose that Cx43 might enhance the activation of Nrf2 (zeige NFE2L2 Antikörper)/ARE pathway by means of inhibiting c-Src (zeige SRC Antikörper) activity to hinder the nuclear export of Nrf2 (zeige NFE2L2 Antikörper), and then reduce expression of FN, ICAM-1 (zeige ICAM1 Antikörper) and TGF-b1, ultimately attenuating renal fibrosis in diabetes.
Upon the induction of autophagy by dexamethasone (Dex), connexin 43 (Cx43) was internalized into autophagosome/autolysosomes and degraded by autophagy.
Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging.
findings suggest that GJA1 may be one of the downstream targets of BMPR1A signaling in osteoclasts that mediates osteoclast-osteoblast communication during bone remodeling.
Down-regulation of Cx43 follows increased CELF1 (zeige CELF1 Antikörper) expression in the dilated cardiomyopathy heart.
we performed cotransfections of AP-1 (zeige JUN Antikörper) expression plasmids with different mouse Gja1 promoter/luciferase reporter constructs within TM3 (zeige TPM1 Antikörper) Leydig and TM4 (zeige TPM4 Antikörper) Sertoli cells.We showed that a functional cooperation between cJun (zeige JUN Antikörper) and cFos activates Gja1 expression and requires an AP-1 (zeige JUN Antikörper) DNA regulatory element located between -132 and -26 bp
weightlessness simulated by using a random position machine promoted the retention of Cx43 in the Golgi apparatus
show that knockout of the gap junction subunit connexin 43 in astrocytes throughout the brain causes excessive sleepiness and fragmented wakefulness during the nocturnal active phase.
Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.
serpinh1b is molecularly and functionally downstream of cx43. The gene serpinh1b codes for a protein called Hsp47, a molecular chaperone (zeige HSP90AA1 Antikörper) responsible for proper folding of procollagen molecules.
Hapln1a (zeige HAPLN1 Antikörper)-ECM (zeige MMRN1 Antikörper) stabilizes the secreted growth factor (zeige WNT2 Antikörper) Semaphorin3d (Sema3d (zeige SEMA3D Antikörper)), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.
Hapln1a (zeige HAPLN1 Antikörper) has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton
Sema3d (zeige SEMA3D Antikörper) functions in a common molecular pathway with Cx43 cell proliferation and joint formation
Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL (zeige COL6A1 Antikörper)) exhibited osteogenic characteristics, in which Cx43 played an important role.
Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.
Data demonstrate a cross-talk between IGF-1R (zeige IGF1R Antikörper) and AT-1R in AT-II and IGF-1 (zeige IGF1 Antikörper)-induced Cx43 expression in SV SMCs involving Erk 1 (zeige MAPK3 Antikörper)/2 and downstream activation of the AP-1 (zeige JUN Antikörper) transcription factor.
Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45 (zeige GJC1 Antikörper).
Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.
This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.
Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.
RhoA (zeige RHOA Antikörper) appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress
Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.
Human TGF-beta1 (zeige TGFB1 Antikörper) induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells
Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.
intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (zeige GJB2 Antikörper), Cx32 (zeige GJB1 Antikörper), and Cx43
CBN (zeige CALB1 Antikörper) blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.
Results describe the effect of suppression of connexin 43 and E-cadherin (zeige CDH1 Antikörper) on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
These findings indicated that Cx43/miR (zeige MYLIP Antikörper)-206 is involved in the pathogenesis of early stage steroid-induced avascular necrosis of the femoral head.
Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.
Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.
In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart
The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.
CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.
Data show that connexin 43 (Cx43) is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.
The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.
we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.
The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 (zeige CDK4 Antikörper) gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.
Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.
Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.
These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.
Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.
Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.
During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.
, gap junction 43 kDa heart protein
, gap junction alpha-1 protein
, gap junction membrane channel protein alpha 1
, connexin 32
, gap junction beta-1 protein
, gap junction membrane channel protein beta 1
, alpha 1 connexin
, gap junction protein, alpha 1
, short fin protein
, gap junction protein, alpha 1, 43 kD (connexin 43)
, vascular smooth muscle connexin-43
, alpha 1 gap junction protein
, gap junction protein, alpha 1, 43kDa (connexin 43)
, gap junction protein alpha 1
, alpha 3 connexin
, gap junction alpha-3 protein
, gap junction membrane channel protein alpha 3