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miR (zeige MLXIP ELISA Kits)-26b plays an anti-metastatic role and is downregulated in gastric cancer tissues via the KPNA2 (zeige KPNA2 ELISA Kits)/c-jun pathway
The IL1B (zeige IL1B ELISA Kits)/AP-1 (zeige FOSB ELISA Kits)/miR (zeige MLXIP ELISA Kits)-30a/ADAMTS-5 (zeige ADAMTS5 ELISA Kits) axis regulates cartilage matrix degradation in osteoarthritis.
TGM2 (zeige TGM2 ELISA Kits) is involved in amyloid-beta (1-42)-induced pro-inflammatory activation via AP1 (zeige FOSB ELISA Kits)/JNK (zeige MAPK8 ELISA Kits) signaling pathways in cultured monocytes.
Integrative genomic analysis indicated overexpression of the AP-1 (zeige FOSB ELISA Kits) transcriptional complex suggesting experimental therapeutic rationales, including blockade of the renin (zeige REN ELISA Kits)-angiotensin system. This led to the repurposing of the angiotensin II receptor antagonist, irbesartan, as an anticancer therapy, resulting in the patient experiencing a dramatic and durable response.
Knockdown of CD44 (zeige CD44 ELISA Kits) reduced the protein level of xCT (zeige SLC7A11 ELISA Kits), a cystine transporter, and increased oxidative stress. However, an increase in GSH was also observed and was associated with enhanced chemoresistance in CD44 (zeige CD44 ELISA Kits)-knockdown cells. Increased GSH was mediated by the Nrf2 (zeige GABPA ELISA Kits)/AP-1 (zeige FOSB ELISA Kits)-induced upregulation of GCLC (zeige GCLC ELISA Kits), a subunit of the enzyme catalyzing GSH synthesis
study highlights the role of AP1 (zeige FOSB ELISA Kits) in promoting the host gene expression profile that defines Ebola virus pathogenesis.
This is the first study to show how TGF-beta (zeige TGFB1 ELISA Kits) regulates the expression of Claudin-4 (zeige CLDN4 ELISA Kits) through c-Jun signaling and how this pathway contributes to the migratory and tumorigenic phenotype of lung tumor cells.
Data show that BRD4 (zeige BRD4 ELISA Kits) controls RUNX2 (zeige RUNX2 ELISA Kits) by binding to the enhancers (ENHs) and each RUNX2 (zeige RUNX2 ELISA Kits) ENH (zeige PDLIM5 ELISA Kits) is potentially controlled by a distinct set of TFs and c-JUN as the principal pivot of this regulatory platform.
AP-1 (zeige FOSB ELISA Kits) likely plays a more important role in the AR cistrome in fibroblasts.
elevated levels of bile acid increase the tumorigenic potential of pancreatic cancer cells by inducing FXR (zeige NR1H4 ELISA Kits)/FAK (zeige PTK2 ELISA Kits)/c-Jun axis to upregulate MUC4 (zeige MUC4 ELISA Kits) expression.
AP-1(c-Jun/FosB (zeige FOSB ELISA Kits)) may play a role in neurogenesis via the induction of FoxD5b expression during early vertebrate development
The cJun transcription factor bound to a variant cAMP response element in the promoter region of tlx3 (zeige TLX3 ELISA Kits) and modulated transcription and regulated neurotransmitter phenotype via its transactivation domain
These results support a role for trim69 (zeige TRIM69 ELISA Kits) in the development of the zebrafish brain through ap-1 pathway.
CPEB-1 (zeige CPEB1 ELISA Kits) control of c-Jun mRNA translation regulates GH gene expression and resulting downstream signaling events (e.g., synaptic plasticity) in the mouse hippocampus.
Overall, our results provide the first evidence that HDAC6 (zeige HDAC6 ELISA Kits) is capable of inducing expression of pro-inflammatory genes by regulating the ROS (zeige ROS1 ELISA Kits)-MAPK (zeige MAPK1 ELISA Kits)-NF-kappaB (zeige NFKB1 ELISA Kits)/AP-1 pathways and serves as a molecular target for inflammation.
c-jun expression patterns suggest that c-jun has a pivotal role in the proliferation of embryonic neural precursor cells, but it has also other roles in adult neurogenesis
Data show that miR (zeige MLXIP ELISA Kits)-200b and miR (zeige MLXIP ELISA Kits)-200c could directly bind the 3' UTR (zeige UTS2R ELISA Kits) of JUN, and JUN activated the transcription of srebp1 (zeige SREBF1 ELISA Kits) to increase lipid accumulation.
transgenic mice overexpressing sPLA2 -IIA (zeige PLA2G2A ELISA Kits) keratinocytes showed enhanced activation of EGFR (zeige EGFR ELISA Kits) and JNK1 (zeige MAPK8 ELISA Kits)/2 that led to c-Jun activation.
ths work provides transcriptional catalog for the developing inner circular smooth muscle and suggests that cJun regulates gene expression in the ICM downstream of Hh signaling.
Jun is required to upregulate a programme of genes associated with cell adhesion as Embryonic stem cells exit the pluripotent ground state.
ANXA11 (zeige ANXA11 ELISA Kits) level regulates lymph node metastases and 5-FU resistance of Hca-P murine hepatocarcinoma cells via c-Jun pathway
Taken together, these findings indicate that LT reduces c-Jun protein levels via two distinct mechanisms, thereby inhibiting critical cell functions, including cellular proliferation.
Ca(2 (zeige CA2 ELISA Kits)+) signaling pathway increases Nr4a1 (zeige NR4A1 ELISA Kits) expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (zeige MEF2C ELISA Kits), AP1, and CREB (zeige CREB1 ELISA Kits) transcription factors thus demonstrating an important interplay between the Ca(2 (zeige CA2 ELISA Kits)+) and cAMP pathways in regulating Nr4a1 (zeige NR4A1 ELISA Kits) expression.
we performed cotransfections of AP-1 expression plasmids with different mouse Gja1 (zeige GJA1 ELISA Kits) promoter/luciferase reporter constructs within TM3 (zeige TPM1 ELISA Kits) Leydig and TM4 (zeige TPM4 ELISA Kits) Sertoli cells.We showed that a functional cooperation between cJun and cFos activates Gja1 (zeige GJA1 ELISA Kits) expression and requires an AP-1 DNA regulatory element located between -132 and -26 bp
aken together, these results reveal that inactivation of Rpd3 (zeige HDAC1 ELISA Kits) independently regulates JNK (zeige MAPK8 ELISA Kits) and Yki (zeige YAP1 ELISA Kits) activities and that both Hippo and JNK (zeige MAPK8 ELISA Kits) signaling pathways contribute to Rpd3 (zeige HDAC1 ELISA Kits) RNAi-induced apoptosis.
Data show that JNK (zeige MAPK8 ELISA Kits) signalling inhibits the growth of losers, while JAK (zeige JAK3 ELISA Kits)/STAT (zeige STAT1 ELISA Kits) signalling promotes competition-induced winner cell proliferation.
Mir (zeige MYLIP ELISA Kits)-8 modulates Drosophila C virus replication by negative regulation of dJun.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (zeige EGFR ELISA Kits)) pathway in the lateral epidermis for sustained dpp (zeige TGFb ELISA Kits) expression in the LE. Specifically, we demonstrate that Egfr (zeige EGFR ELISA Kits) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (zeige MAPK8 ELISA Kits) signaling
Tau and spectraplakin promote synapse formation and maintenance through Jun kinase (zeige MAPK9 ELISA Kits) and neuronal trafficking.
n addition to significantly increasing the number of JNK (zeige MAPK8 ELISA Kits) target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK (zeige MAPK8 ELISA Kits), segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1 (zeige SCRIB ELISA Kits)) tumors requires bZIP protein Fos, the ETS (zeige ETS1 ELISA Kits)-domain factor Ets21c and the nuclear receptor Ftz-F1 (zeige NR5A2 ELISA Kits), all acting downstream of Jun-N-terminal kinase (zeige MAPK8 ELISA Kits).
Diminished MTORC1-dependent JNK (zeige MAPK8 ELISA Kits) activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (zeige ROS1 ELISA Kits)/JNK (zeige MAPK8 ELISA Kits)/p38 (zeige MAPK14 ELISA Kits)/Upd (zeige UROD ELISA Kits) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK (zeige MAPK8 ELISA Kits) pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (zeige NOTCH1 ELISA Kits)-Src (zeige SRC ELISA Kits) synergy.
study highlights the role of AP1 in promoting the host gene expression profile that defines Ebola virus pathogenesis.
Porcine reproductive and respiratory syndrome virus -activated TAK-1 (zeige NR2C2 ELISA Kits) was essential for the activation of JNK (zeige MAPK8 ELISA Kits) and NF-kappaB (zeige NFKB1 ELISA Kits) pathways and IL-8 (zeige IL8 ELISA Kits) expression.
The effects of prostaglandin F2alpha administration on transcription factor AP-1 expression and the expression of downstream genes involved in luteolysis are reported.
ICAM1 (zeige ICAM1 ELISA Kits) and IL10 (zeige IL10 ELISA Kits) were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 may be responsible for this upregulation.
The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 DNA-binding activity and expression of several transcriptions factors in breast cancer cells.
dynamic compression stimulates cell proliferation and proteoglycan (zeige Vcan ELISA Kits) synthesis in the presence of IL-1beta (zeige IL1B ELISA Kits) and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Jun activation domain binding protein
, activator protein 1
, enhancer-binding protein AP1
, jun oncogene
, proto-oncogene c-Jun
, transcription factor AP-1
, v-jun avian sarcoma virus 17 oncogene homolog
, v-jun sarcoma virus 17 oncogene homolog
, Avian sarcoma virus 17 (v-jun) oncogene homolog
, Jun oncogene
, V-jun avian sarcoma virus 17 oncogene homolog
, proto-oncogene c-jun
, CDK5 activator 2
, cyclin-dependent kinase 5 activator 2
, cyclin-dependent kinase 5 regulatory subunit 2
, v-jun sarcoma virus 17 oncogene
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, immediate early
, jun A
, Jun related antigen
, complementation group V
, LOW QUALITY PROTEIN: transcription factor AP-1