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anti-Human BUB3 Antikörper:
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Human Polyclonal BUB3 Primary Antibody für ICC, ELISA - ABIN1001948
Kalitsis, Earle, Fowler, Choo: Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. in Genes & development 2000
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Human Monoclonal BUB3 Primary Antibody für BI, WB - ABIN968648
Martinez-Exposito, Kaplan, Copeland, Sorger: Retention of the BUB3 checkpoint protein on lagging chromosomes. in Proceedings of the National Academy of Sciences of the United States of America 1999
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Human Monoclonal BUB3 Primary Antibody für BI, WB - ABIN968647
Taylor, Ha, McKeon: The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. in The Journal of cell biology 1998
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Human Polyclonal BUB3 Primary Antibody für ICC, IF - ABIN4285582
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Human Polyclonal BUB3 Primary Antibody für ICC, ELISA - ABIN1887091
Jiang, Li, Yang, Hawke, Zheng, Xia, Aldape, Wei, Guo, Chen, Lu: PKM2 regulates chromosome segregation and mitosis progression of tumor cells. in Molecular cell 2014
Human Polyclonal BUB3 Primary Antibody für WB - ABIN1981301
Morais da Silva, Moutinho-Santos, Sunkel: A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition. in The Journal of cell biology 2013
The integrity of the mitotic checkpoint complex depends on the specific recognition between BubR1 (zeige BUB1B Antikörper) and Bub3, for which the BubR1 (zeige BUB1B Antikörper) Gle2 (zeige RAE1 Antikörper) binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 (zeige BUB1B Antikörper) and BUB3 by BUB1 (zeige BUB1 Antikörper) is dispensable for SAC (zeige ADCY10 Antikörper) activation
a mutual antagonism exists between Bub3 and dynein to ensure optimal KT-MT attachments
the mechanisms of BUB3 in mitotic checkpoint signaling
Data show sequential multisite regulation of the microtubule-associated protein KNL1 (zeige CASC5 Antikörper)-kinase-adaptor complex BUB1 (zeige BUB1 Antikörper)/BUB3 interaction.
Data indicate that cell cycle protein Bub3-mediated kinetochore recruitment of BubR1 (zeige BUB1B Antikörper) kinase enhances mitotic checkpoint signaling.
Results suggest that these USP7 (zeige USP7 Antikörper)-dependent effects are mediated by decreased levels of spindle assembly checkpoint (SAC (zeige ADCY10 Antikörper)) component Bub3.
Mutations targeting the Bub3 interface prevent kinetochore recruitment of the SAC (zeige ADCY10 Antikörper) kinase Bub1 (zeige BUB1 Antikörper). Crucially, they also cause a checkpoint defect, showing that recognition of phosphorylated targets by Bub3 is required for checkpoint signaling
Results showed that neither variants in BUB3 nor variants in MAD2L1 (zeige MAD2L1 Antikörper) caused any significant effect on the risk of breast cancer
Mutations in BUB1 (zeige BUB1 Antikörper) and BUB3 cause mosaic variegated aneuploidy and increase the risk of colorectal cancer at a young age.
Data show that Zfp207 binds to Bub3 to form a complex and maintains its protein level in oocytes, and that overexpression of Bub3 is able to partially rescue the occurrence of aneuploid eggs in Zfp207-depleted oocytes.
as a member of the spindle assembly checkpoint, Bub3 is required for regulation of both meiosis I and II, and is potentially involved in kinetochore-microtubule attachment in mammalian oocytes
Cenpa (zeige CENPA Antikörper), Cenpb (zeige CENPB Antikörper), and Bub3, but not Cenpc (zeige CENPC1 Antikörper), interacted with PARP-1 (zeige PARP1 Antikörper)
Haploinsufficiency of Bub3 causes a slight increase in chromosome instability but is not clearly associated with a noticeable rise in the probability of tumor formation.
subpopulation of dynein, containing the DYNLT3 (zeige DYNLT3 Antikörper) light chain, may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
BUB3 budding uninhibited by benzimidazoles 3 homolog
, budding uninhibited by benomyl
, budding uninhibited by benzimidazoles 3 homolog
, mitotic checkpoint component
, mitotic checkpoint protein BUB3
, WD repeat protein Bub3
, WD repeat type I transmembrane protein A72.5