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STAT1 Proteine (STAT1)

Bezeichnung:
Signal Transducer and Activator of Transcription 1, 91kDa Proteine (STAT1)
Auf www.antikoerper-online.de finden Sie aktuell 21 Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Proteine von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen STAT1 Antikörper (604) und STAT1 Kits (46) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 715 STAT1 Produkte verfügbar.
Synonyme:
2010005J02Rik, AA408197, CANDF7, DD6G4-4, dZ182H3.3, H2RSP, IMUP, IMUP-1, IMUP-2, ISGF-3, si:by51f19.1, si:by134g18.2, si:dz73o4.2, si:dz182h3.3, si:dz199m19.1, STAT, STAT1, STAT4, STAT91, XStat1
alle Proteine anzeigen Gen GeneID UniProt
STAT1 72275  
Ratte STAT1 STAT1 25124  
STAT1 6772 P42224

Weitere Synonyme anzeigen

STAT1 Proteine (STAT1) nach Spezies

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Am meisten referenzierte STAT1 Proteine

  1. Human STAT1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005323 : Ungureanu, Vanhatupa, Kotaja, Yang, Aittomaki, Jänne, Palvimo, Silvennoinen: PIAS proteins promote SUMO-1 conjugation to STAT1. in Blood 2003 (PubMed)
    Zeige alle 4 Referenzen für ABIN2005323

  2. Human STAT1 Protein expressed in Escherichia coli (E. coli) - ABIN667813 : Farlik, Reutterer, Schindler, Greten, Vogl, Müller, Decker: Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. in Immunity 2010 (PubMed)

Weitere Proteine zu STAT1 Interaktionspartnern

Mouse (Murine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Interaktionspartner

  1. We found that STAT-1(-/-) MRL lpr (zeige FAS Proteine) mice, but not IRF-9 (zeige IRF9 Proteine)(-/-) or IFNAR-2 (zeige IFNAR2 Proteine)(-/-) mice, developed interstitial nephritis characterized by infiltration with RORgammat-positive lymphocytes, macrophages, and eosinophils. Despite pronounced interstitial kidney disease and abnormal kidney function, STAT-1(-/-) mice had decreased proteinuria, glomerulonephritis, and autoantibody production.

  2. Y37L substitution in STAT1 accounted for high flavivirus susceptibility of a mouse strain.

  3. IFN-I can mediate ISG expression inmixed glial cell cultures (MGCs) via ISGF3 (zeige IRF9 Proteine)-independent signaling pathways but with reduced efficiency, with delayed and prolonged kinetics, and is more dependent on STAT1 and STAT2 (zeige STAT2 Proteine) than IRF9 (zeige IRF9 Proteine); and 2) signaling pathways not involving STAT1, STAT2 (zeige STAT2 Proteine), or IRF9 (zeige IRF9 Proteine) play a minor role only in mediating IFN-alpha (zeige IFNA Proteine)-stimulated genes expression in MGCs.

  4. These results demonstrate a novel mechanism by which STAT1 negatively regulates ULK1 (zeige ULK1 Proteine) expression and autophagy.

  5. a novel negative feedback loop mediated by STAT3 (zeige STAT3 Proteine)-SOCS3 (zeige SOCS3 Proteine), which is tightly controlled by SENP1 (zeige SENP1 Proteine) via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B (zeige PTPN1 Proteine)), in IFN-gamma (zeige IFNG Proteine) signaling, is reported.

  6. In a mouse model of spontaneous osteopenia caused by hyperactivation of STAT1/3 signaling downstream of gp130 (gp130 (zeige LRPPRC Proteine)(Y757F/Y757F)), STAT1 deletion rescued the osteopenic phenotype, indicating a beneficial effect of promoting STAT3 (zeige STAT3 Proteine) signaling over STAT1 downstream of gp130 (zeige LRPPRC Proteine) in this low bone mass condition, and this may have therapeutic value.

  7. this study shows that STAT-1 and STAT-3 (zeige STAT3 Proteine) interplay to regulate indoleamine 2,3-dioxygenase activity and immunosuppression in response to of IL-27 (zeige IL27 Proteine) in neonatal macrophages

  8. this study shows that binding motifs for the transcription factors STAT1 and IRF1 (zeige IRF1 Proteine) are associated with robust and IL-4 (zeige IL4 Proteine)-resistant responses to IFN-gamma (zeige IFNG Proteine) in macrophages

  9. Study showed that suppression of STAT3 (zeige STAT3 Proteine), STAT5 (zeige STAT5A Proteine), and STAT6 (zeige STAT6 Proteine) and overexpression of the proapoptotic factor STAT1, which provides p53 (zeige TP53 Proteine)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (zeige ERBB2 Proteine) tyrosine kinase receptor (zeige KDR Proteine) overexpression promotes neuronal survival through activation of STAT-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1

  10. STAT signaling plays a central role during retinal degeneration in the rd10 (zeige PDE6B Proteine) mouse model.

Human Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Interaktionspartner

  1. results indicated that USP18 (zeige USP18 Proteine) modulates the anti-HBV activity of IFN-F via activation of the JAK (zeige JAK3 Proteine)/STAT signaling pathway in Hepg2.2.15 cells.

  2. nicotine-mediated induction of alpha7 nAChR (zeige CHRNA7 Proteine) was reduced when E2F1 (zeige E2F1 Proteine) was depleted and in contrast elevated when STAT1 was depleted by siRNAs.

  3. Data suggest PML (promyelocytic leukemia protein (zeige PML Proteine)) positively regulates STAT1 and STAT2 (zeige STAT2 Proteine) isgylation, a ubiquitination-like protein modification; PML (zeige PML Proteine) exhibits potent angiostatic activity, doing so in part by forming a positive feedforward loop with STAT1/2 and a negative feedback loop with STAT3 (zeige STAT3 Proteine). (STAT = signal transducer and activator of transcription)

  4. the dual regulation of STAT1 by IKKalpha (zeige CHUK Proteine) in antiviral signaling suggests a role for IKKalpha (zeige CHUK Proteine) in the fine-tuning of antiviral signaling in response to non-self RNA.

  5. This study demonstrated the first coiled-coil domain mutation of STAT1 as a genetic cause of autosomal-dominant Mendelian susceptibility to mycobacterial diseases

  6. STAT1 suppression by S100A6 (zeige S100A6 Proteine) may represent a promising therapeutic target to facilitate reendothelialization in damaged vessels.

  7. Our data demonstrate an important connection between mRNA translation and KRAS tumorigenesis under the control of STAT1, which can determine the susceptibility of KRAS tumors to pharmacologic inhibition of mRNA translation initiation.

  8. study demonstrated that miR (zeige MLXIP Proteine)-9 could inhibit activation of the NLRP3 (zeige NLRP3 Proteine) inflammasome and attenuate atherosclerosis-related inflammation, likely through the JAK1 (zeige JAK1 Proteine)/STAT1 signaling pathway. Therefore, miR (zeige MLXIP Proteine)-9 may serve as a potential therapeutic target for atherosclerosis.

  9. the deubiquitinase USP2a translocates into the nucleus and binds to pY701-STAT1, and inhibits K48-linked ubiquitination and degradation of pY701-STAT1

  10. Demonstrate STAT1-dependent transcriptional activation of TLR8 (zeige TLR8 Proteine) with estrogen stimulation.

Pig (Porcine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Interaktionspartner

  1. Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (zeige IFNA Proteine) response by inducing STAT1 degradation.

  2. this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets

  3. Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (zeige JAK3 Proteine)-STAT1) signaling pathway.

  4. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (zeige STAT2 Proteine) nuclear translocation.

  5. Nsp1beta inhibits interferon-activated (zeige MNDA Proteine) STAT1/STAT2 (zeige STAT2 Proteine) signal transduction by inducing karyopherin-alpha1 degradation.

  6. STAT1 is involved in mediating the action of ghrelin (zeige GHRL Proteine) on ovarian cell functions.

  7. the majority of the STAT1/STAT2 (zeige STAT2 Proteine)/IRF9 (zeige IRF9 Proteine) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

  8. Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.

  9. Nitric oxide-dependent increase in caspase-8 (zeige CASP8 Proteine) mRNA levels is associated with phosphorylation of STAT-1 at Ser (zeige SIGLEC1 Proteine)-727 and STAT1 binding to the caspase-8 (zeige CASP8 Proteine) promoter in cultured lung endothelial cells.

  10. Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.

Cow (Bovine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Interaktionspartner

  1. Report interferon-tau dependent STAT1 regulation of SOCS (zeige CISH Proteine) genes in bovine endometrium during estrus cycle and embryo implantation.

  2. the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate

  3. results show for the first time that interleukin-6 (zeige IL6 Proteine) (IL), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1/STAT3 (zeige STAT3 Proteine) proteins in bovine articular chondrocytes

  4. Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (zeige CSN2 Proteine) synthesis and fat metabolism.

  5. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (zeige STAT2 Proteine).

STAT1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT1

  • signal transducer and activator of transcription 1, 91kDa (STAT1)
  • RIKEN cDNA 2200002D01 gene (2200002D01Rik)
  • signal transducer and activator of transcription 1 (Stat1)
  • signal transducer and activator of transcription 1, 91kDa (stat1)
  • signal transducer and activator of transcription 4 (stat4)
  • 2010005J02Rik Protein
  • AA408197 Protein
  • CANDF7 Protein
  • DD6G4-4 Protein
  • dZ182H3.3 Protein
  • H2RSP Protein
  • IMUP Protein
  • IMUP-1 Protein
  • IMUP-2 Protein
  • ISGF-3 Protein
  • si:by51f19.1 Protein
  • si:by134g18.2 Protein
  • si:dz73o4.2 Protein
  • si:dz182h3.3 Protein
  • si:dz199m19.1 Protein
  • STAT Protein
  • STAT1 Protein
  • STAT4 Protein
  • STAT91 Protein
  • XStat1 Protein

Bezeichner auf Proteinebene für STAT1

signal transducer and activator of transcription 1-alpha/beta , HAI-2 related small protein , signal transducer and activator of transcription-1 , transcription factor ISGF-3 components p91/p84 , signal transducer and activator of transcription 4 , signal transducer and activator of transcription 1 , transcription factor ISGF-3 , activator of transcription , signal transduction

GENE ID SPEZIES
100307049 Ovis aries
72275 Mus musculus
20846 Mus musculus
25124 Rattus norvegicus
6772 Homo sapiens
424044 Gallus gallus
488449 Canis lupus familiaris
396655 Sus scrofa
510814 Bos taurus
398324 Xenopus laevis
100343893 Oryctolagus cuniculus
368519 Danio rerio
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