STAT1 Proteine (STAT1)

Signal Transducer and Activator of Transcription 1, 91kDa Proteine (STAT1)
Auf finden Sie aktuell 21 Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Proteine von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen STAT1 Antikörper (635) und STAT1 Kits (46) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 747 STAT1 Produkte verfügbar.
2010005J02Rik, AA408197, CANDF7, DD6G4-4, dZ182H3.3, H2RSP, IMUP, IMUP-1, IMUP-2, ISGF-3, si:by51f19.1, si:by134g18.2, si:dz73o4.2, si:dz182h3.3, si:dz199m19.1, STAT, STAT1, STAT4, STAT91, XStat1
alle Proteine anzeigen Gen GeneID UniProt
STAT1 72275  
Ratte STAT1 STAT1 25124  
STAT1 6772 P42224

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Am meisten referenzierte STAT1 Proteine

  1. Human STAT1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005323 : Ungureanu, Vanhatupa, Kotaja, Yang, Aittomaki, Jänne, Palvimo, Silvennoinen: PIAS proteins promote SUMO-1 conjugation to STAT1. in Blood 2003 (PubMed)
    Zeige alle 4 Referenzen für 2005323

  2. Human STAT1 Protein expressed in Escherichia coli (E. coli) - ABIN667813 : Farlik, Reutterer, Schindler, Greten, Vogl, Müller, Decker: Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. in Immunity 2010 (PubMed)

Weitere Proteine zu STAT1 Interaktionspartnern

Mouse (Murine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Interaktionspartner

  1. Data demonstrate that STAT1 is a key orchestrator of cytokine-producing innate lymphoid cells responses during viral infection via ILC (zeige CCL27 Proteine)-extrinsic regulation of IL-33 (zeige IL33 Proteine) and IL-23 (zeige IL23A Proteine).

  2. NKLAM is a positive regulator of STAT1-mediated transcriptional activity and is an important component of the innate immune response.

  3. In cultured macrophages, LPS (zeige TLR4 Proteine)-induced expression of monocyte chemoattractant protein (MCP)-1 (zeige CPT1B Proteine) was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta (zeige NFKBIZ Proteine) activities.

  4. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (zeige MAPK14 Proteine), AAT (zeige SERPINA1A Proteine), signal transducer and activator of transcription 1 (STAT1) and activating transcription factor2 (ATF2 (zeige ATF2 Proteine))

  5. This secreted effector, toxoplasma inhibitor of STAT1-dependent transcription (TgIST), translocates to the host cell nucleus, where it recruits mouse Mi-2 (zeige CHD4 Proteine)/NuRD to STAT1-dependent promoters, resulting in altered chromatin and blocked transcription.

  6. Microbiome depletion as a result of broad-spectrum antibiotic treatment disrupts basal Stat1 signaling and alters T-cell homeostasis, leading to impaired progenitor maintenance and granulocyte maturation.

  7. We revealed that in mouse mesenchymal stem cells IFN-gamma-induced (zeige SAMHD1 Proteine) immunoregulation is mediated by early phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT3 (zeige STAT3 Proteine), which is significantly enhanced by an extracellular signal-regulated kinase 1/2 (zeige MAPK3 Proteine)-dependent mTOR (zeige FRAP1 Proteine) inhibition, thereby promoting pSTAT1 nuclear translocation.

  8. these results define a differential regulation of TLR-mediated activation and differentiation of MZ B cells by STAT1 and reveal a STAT1-dependent, but IFN-independent, antibody response during infection and inflammation.

  9. B cell-intrinsic IFN-gamma (zeige IFNG Proteine) receptor (IFN-gammaR (zeige IFNGR1 Proteine)) and STAT1 signaling are required for Spontaneously developed germinal centers and follicular T helper cell (Tfh cell) development.

  10. Inhibitor-sensitive tyrosine kinase (zeige TYRO3 Proteine) controls the population heterogeneity of basal STAT1 activity in Ube1l (zeige UBA7 Proteine) deficient fibroblasts.

Human Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Interaktionspartner

  1. MACC1 (zeige MACC1 Proteine) regulates Fas (zeige FAS Proteine) mediated apoptosis through STAT1/3 - Mcl-1 (zeige MCL1 Proteine) signaling in solid cancers.

  2. the phosphorylation of signal transducer and activator of transcription 1 (STAT1-py) was impaired in asthmatics, whereas the phosphorylation of signal transducer and activator of transcription 6 (STAT6 (zeige STAT6 Proteine)-py) was slightly enhanced.

  3. MFSD2B, CCL20 (zeige CCL20 Proteine) and STAT1, or STARD7 (zeige STARD7 Proteine) and ZNF512 genes may be risk or protect factors in prognosis of ADC (zeige ADC Proteine); HTR2B (zeige HTR2B Proteine), DPP4 (zeige DPP4 Proteine), and TGFBRAP1 (zeige TGFBRAP1 Proteine) genes may be risk factors in prognosis of SQC (zeige QPCT Proteine).

  4. In cultured macrophages, LPS (zeige IRF6 Proteine)-induced expression of monocyte chemoattractant protein (MCP)-1 (zeige CCL2 Proteine) was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta (zeige NFKBIZ Proteine) activities.

  5. Functional analysis of NK cells shows a significant impairment of cytolytic and degranulation activities in chronic mucocutaneous candidiasis patients with STAT1 GOF mutations

  6. Mechanistic investigations reveal that AJUBA (zeige AJUBA Proteine) specifically binds the FERM domain of JAK1 (zeige JAK1 Proteine) to dissociate JAK1 (zeige JAK1 Proteine) from the IFNgamma recepter, resulting in an inhibition of STAT1 phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA (zeige AJUBA Proteine) in CRC (zeige CALR Proteine) specimens is negatively correlated with the levels of IFIT2 (zeige IFIT2 Proteine) and pSTAT1

  7. Low STAT1 expression is associated with Pancreatic cancer.

  8. STAT1 and IRF1 (zeige IRF1 Proteine) collaborate to induce interferon-gamma (zeige IFNG Proteine) stimulated genes (ISGs), but the extent to which they act alone or together is unclear.This study provides strong evidence for widespread cooperation between STAT1 and IRF1 (zeige IRF1 Proteine) at ISGs, and suggests that in silico predictions reliably predict the effect of nucleotide variants on binding in vivo.

  9. IFITM1 (zeige IFITM1 Proteine) suppression blocks proliferation and invasion of aromatase (zeige CYP19A1 Proteine) inhibitor-resistant breast cancer in vivo by JAK (zeige JAK3 Proteine)/STAT1-mediated induction of p21 (zeige CDKN1A Proteine).

  10. This study reports a new role for SETD2 in promoting IFNalpha-induced antiviral immune response by directly methylating STAT1 on lysine 525 and catalyzing H3K36me3 on the promoters of some IFN-stimulated genes (ISGs such as ISG15) to activate gene transcription. Thus, SETD2 enhances host antiviral immunity by strengthening IFNalpha signaling both post-translationally and epigenetically.

Pig (Porcine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Interaktionspartner

  1. Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (zeige IFNA Proteine) response by inducing STAT1 degradation.

  2. this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets

  3. Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (zeige JAK3 Proteine)-STAT1) signaling pathway.

  4. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (zeige STAT2 Proteine) nuclear translocation.

  5. Nsp1beta inhibits interferon-activated (zeige MNDA Proteine) STAT1/STAT2 (zeige STAT2 Proteine) signal transduction by inducing karyopherin-alpha1 degradation.

  6. STAT1 is involved in mediating the action of ghrelin (zeige GHRL Proteine) on ovarian cell functions.

  7. the majority of the STAT1/STAT2 (zeige STAT2 Proteine)/IRF9 (zeige IRF9 Proteine) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

  8. Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.

  9. Nitric oxide-dependent increase in caspase-8 (zeige CASP8 Proteine) mRNA levels is associated with phosphorylation of STAT-1 at Ser (zeige SIGLEC1 Proteine)-727 and STAT1 binding to the caspase-8 (zeige CASP8 Proteine) promoter in cultured lung endothelial cells.

  10. Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.

Cow (Bovine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Interaktionspartner

  1. Report interferon-tau dependent STAT1 regulation of SOCS (zeige CISH Proteine) genes in bovine endometrium during estrus cycle and embryo implantation.

  2. the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate

  3. results show for the first time that interleukin-6 (zeige IL6 Proteine) (IL), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1/STAT3 (zeige STAT3 Proteine) proteins in bovine articular chondrocytes

  4. Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (zeige CSN2 Proteine) synthesis and fat metabolism.

  5. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (zeige STAT2 Proteine).

STAT1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT1

  • signal transducer and activator of transcription 1, 91kDa (STAT1)
  • RIKEN cDNA 2200002D01 gene (2200002D01Rik)
  • signal transducer and activator of transcription 1 (Stat1)
  • signal transducer and activator of transcription 1, 91kDa (stat1)
  • signal transducer and activator of transcription 4 (stat4)
  • 2010005J02Rik Protein
  • AA408197 Protein
  • CANDF7 Protein
  • DD6G4-4 Protein
  • dZ182H3.3 Protein
  • H2RSP Protein
  • IMUP Protein
  • IMUP-1 Protein
  • IMUP-2 Protein
  • ISGF-3 Protein
  • si:by51f19.1 Protein
  • si:by134g18.2 Protein
  • si:dz73o4.2 Protein
  • si:dz182h3.3 Protein
  • si:dz199m19.1 Protein
  • STAT Protein
  • STAT1 Protein
  • STAT4 Protein
  • STAT91 Protein
  • XStat1 Protein

Bezeichner auf Proteinebene für STAT1

signal transducer and activator of transcription 1-alpha/beta , HAI-2 related small protein , signal transducer and activator of transcription-1 , transcription factor ISGF-3 components p91/p84 , signal transducer and activator of transcription 4 , signal transducer and activator of transcription 1 , transcription factor ISGF-3 , activator of transcription , signal transduction

100307049 Ovis aries
72275 Mus musculus
20846 Mus musculus
25124 Rattus norvegicus
6772 Homo sapiens
424044 Gallus gallus
488449 Canis lupus familiaris
396655 Sus scrofa
510814 Bos taurus
398324 Xenopus laevis
100343893 Oryctolagus cuniculus
368519 Danio rerio
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