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SOCS1 Proteine (SOCS1)

Suppressor of Cytokine Signaling 1 Proteine (SOCS1)
Auf finden Sie aktuell 13 Suppressor of Cytokine Signaling 1 (SOCS1) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SOCS1 Antikörper (172) und SOCS1 Kits (23) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 222 SOCS1 Produkte verfügbar.
CIS1, Cish1, Cish7, JAB, LOC100228306, Socs-1, SOCS1, socs1b, SSI-1, SSI1, TIP3, zgc:91868
alle Proteine anzeigen Gen GeneID UniProt
SOCS1 8651 O15524
SOCS1 12703 O35716
SOCS1 252971 Q9QX78

Weitere Synonyme anzeigen

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Weitere Proteine zu SOCS1 Interaktionspartnern

Zebrafish Suppressor of Cytokine Signaling 1 (SOCS1) Interaktionspartner

  1. Socs1a transgenic zebrafish have liver steatosis and insulin (zeige INS Proteine) resistance.

  2. Studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2 (zeige JAK2 Proteine)-Stat5 (zeige STAT5B Proteine) pathway.

  3. in homozygotes, GH signaling is reduced by the action of the SOCS1 and SOCS3 (zeige SOCS3 Proteine) proteins.

Rhesus Monkey Suppressor of Cytokine Signaling 1 (SOCS1) Interaktionspartner

  1. SOCS1 alleviates RhTRIM5alpha-mediated regulation in the late phase of HIV-1 life cycle probably due to the destabilization of RhTRIM5alpha.

Rainbow Trout (Oncorhynchus mykiss) Suppressor of Cytokine Signaling 1 (SOCS1) Interaktionspartner

  1. The upregulation of SOCS-1 and SOCS-2 (zeige SOCS2 Proteine) by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.

Human Suppressor of Cytokine Signaling 1 (SOCS1) Interaktionspartner

  1. This study showed that SOCS5 (zeige SOCS5 Proteine) expression was significantly down-regulated.

  2. this study shows that IL-7 (zeige IL7 Proteine) induces the expression of SOCS1 through the JAK (zeige JAK3 Proteine)/STAT-5 (zeige STAT5A Proteine) pathway

  3. SOCS1 silencing can inhibit proliferation and induce apoptosis of MV3 and A357 melanoma cells in vivo and in vitro by inhibiting extracellular signal-regulated kinase and janus kinase signal transduction and activators of transcription signaling pathways.

  4. SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 (zeige TP53 Proteine) signaling.

  5. The results revealed that although the expression levels of SOCS1, SOCS3 (zeige SOCS3 Proteine) and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 (zeige PIAS3 Proteine) downregulation is more negatively correlated with STAT3 (zeige STAT3 Proteine) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.

  6. findings provide novel insight into how dysregulated expression of SOCS (zeige CISH Proteine) increases IL-4 (zeige IL4 Proteine) responses in allergic monocytes, and this may represent a new therapeutic avenue for managing allergic disease.

  7. Overexpression of SOCS1 has a potent antitumor effect against ESCC.

  8. IL-4 (zeige IL4 Proteine) signaling plays a crucial role in the regulatory functions of SOCS1 in apoptosis and inflammation in human osteoarthritic chondrocytes. These findings provide a potential therapeutic target for the clinical treatment of osteoarthritis (OA)

  9. We demonstrated that VDR (zeige CYP27B1 Proteine)/miRNA155-modulated SOCS1 expression is decreased in PBC (zeige DLAT Proteine) which may lead to insufficient negative regulation of cytokine signaling. These findings suggest that the decreased VDR (zeige CYP27B1 Proteine) signaling in PBC (zeige DLAT Proteine) could be of importance in the pathogenesis of PBC (zeige DLAT Proteine).

  10. Through promoter hypermethylation, the SOCS-1 gene was severely down-regulated in the colorectal cancer tissue samples.

Mouse (Murine) Suppressor of Cytokine Signaling 1 (SOCS1) Interaktionspartner

  1. this study shows that genetic modification of dendritic cells with SOCS1 affects their activation and maturation, inhibits T-cell proliferation and induces hypo-responsiveness, and prolongs islet allograft survival

  2. SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 (zeige TP53 Proteine) signaling.

  3. Kdm5a (zeige KDM5A Proteine) associates with p50 (zeige LSP1 Proteine) and binds to the Socs1 promoter region in resting natural killer cells.

  4. The miR (zeige MLXIP Proteine)-155 inhibitor relieves liver injury by enhancing the expression of SOCS1 and inactivating JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling.

  5. NOS1 (zeige NOS1 Proteine)-derived nitric oxide promotes NF-kappaB (zeige NFKB1 Proteine) transcriptional activity through inhibition of Socs1.Cys147 and Cys179 are essential for SOCS1 nitrosation and proteasomal degradation.

  6. mir (zeige MLXIP Proteine)-155 deficiency attenuates liver ischemia-reperfusion injury through upregulation of SOCS1, which is associated with promotion of M2 macrophage and inhibition of Th17 differentiation

  7. Findings indicate that SOCS1 mediates its tumor suppressor functions, at least partly, by binding to MET and interfering with downstream signaling pathways as well as by promoting the turnover of the activated MET receptor.

  8. increased expression of SOCS-1 in the lungs of mice significantly protects against hyperoxic lung injury.

  9. Overexpression of SOCS1 in transgenic rat eyes attenuated ocular HSV-1 infection

  10. Axl (zeige AXL Proteine) promotes STAT1 (zeige STAT1 Proteine) signaling via inhibition of SOCS1 in activated smooth muscle cells in vein graft remodeling.

SOCS1 Protein Überblick

Protein Überblick

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Alternative names and synonyms associated with SOCS1

  • suppressor of cytokine signaling 1a (socs1a)
  • suppressor of cytokine signaling 1 (socs1)
  • suppressor of cytokine signaling 1 (SOCS1)
  • suppressor of cytokine signaling 1 (LOC100228306)
  • suppressor of cytokine signaling 1 (socs1-b)
  • suppressor of cytokine signaling 1-like protein (socs1)
  • suppressor of cytokine signaling 1 (Socs1)
  • CIS1 Protein
  • Cish1 Protein
  • Cish7 Protein
  • JAB Protein
  • LOC100228306 Protein
  • Socs-1 Protein
  • SOCS1 Protein
  • socs1b Protein
  • SSI-1 Protein
  • SSI1 Protein
  • TIP3 Protein
  • zgc:91868 Protein

Bezeichner auf Proteinebene für SOCS1

suppressor of cytokine signaling 1 , suppressor of cytokine signalling , suppressor of cytokine signaling 1b , suppressor of cytokine signaling 1-like protein , JAK binding protein , JAK-binding protein , STAT induced SH3 protein 1 , STAT-induced STAT inhibitor 1 , TIP-3 , Tec-interacting protein 3 , cytokine-inducible SH2 protein 1 , JAK2-binding protein , cytokine inducible SH2-containing protein 1 , cytokine inducible SH2-containing protein 7

445073 Danio rerio
496789 Xenopus (Silurana) tropicalis
711180 Macaca mulatta
737070 Pan troglodytes
100144374 Oryzias latipes
100228306 Taeniopygia guttata
100272210 Oncorhynchus mykiss
100294520 Xenopus laevis
100049621 Takifugu rubripes
8651 Homo sapiens
12703 Mus musculus
416630 Gallus gallus
490006 Canis lupus familiaris
252971 Rattus norvegicus
518795 Bos taurus
100307052 Sus scrofa
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