Methyl CpG Binding Protein 2 Proteine (MECP2)

Bezeichnung:
Methyl CpG Binding Protein 2 Proteine (MECP2)
Auf www.antikoerper-online.de finden Sie aktuell 13 Methyl CpG Binding Protein 2 (MECP2) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Methyl CpG Binding Protein 2 Antikörper (233) und Methyl CpG Binding Protein 2 Kits (13) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 273 Methyl CpG Binding Protein 2 Produkte verfügbar.
Synonyme:
1500041B07Rik, AUTSX3, BB130002, D630021H01Rik, Mbd5, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, WBP10, wu:fk96a04, zgc:111857
alle Proteine anzeigen Gen GeneID UniProt
MECP2 4204 P51608
MECP2 17257 Q9Z2D6
MECP2 29386 Q00566

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Am meisten referenzierte Methyl CpG Binding Protein 2 Proteine

  1. Human MECP2 Protein expressed in Wheat germ - ABIN1310622 : Nott, Cheng, Gao, Lin, Gjoneska, Ko, Minhas, Zamudio, Meng, Zhang, Jin, Tsai: Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. in Nature neuroscience 2016 (PubMed)

Weitere Proteine zu Methyl CpG Binding Protein 2 Interaktionspartnern

Human Methyl CpG Binding Protein 2 (MECP2) Interaktionspartner

  1. When it binds methylated/hydroxymethylated DNA, MeCP2 recruits various interacting protein and RNA partners, resulting in a highly specialized chromatin organization wherein linker histones and MeCP2 share an organizational role that dynamically changes during neuronal development. MeCP2 mutations alter its chromatin-binding dynamics and interactions with some of its partners, causing Rett syndrome. Review.

  2. MeCP2 regulates IGF1 (zeige IGF1 Proteine) and BDNF (zeige BDNF Proteine) levels, and when this gene is mutated both proteins have their expression decreased. In our study, we show that IGF1 (zeige IGF1 Proteine) gene expression was not different between control and RTT neurons. Interestingly, IGF1R (zeige IGF1R Proteine) has its gene expression increased in RTT neural cells compared to control

  3. The expression of Rb and MeCP2 in patients with B-cell non-Hodgkin's lymphoma (B-NHL) showed that positive staining for MeCP2 or Rb was significantly lower in B-NHL tumor tissues, and these changes were significantly and negatively correlated with the grade of B-NHL.

  4. MECP2 was increased at both mRNA and protein levels in gastric cancer (GC) compared with paracancerous tissues; MECP2 positive expression was correlated with the TNM stages, histological types, and lymph node metastasis status, but not with sex or age; dysregulated expression of MECP2 in GC and its correlation to clinicopathological parameters indicate that MECP2 may regulate the development of GC

  5. that histone deacetylase 3 (zeige HDAC3 Proteine) interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (zeige FOXO3 Proteine) deacetylation, and disruption of HDAC3 (zeige HDAC3 Proteine) contributes to cognitive and social impairment

  6. C- and N-terminal interactions are required for healthy function of MeCP2.

  7. These findings position MeCP2 as a novel component in metabolic homeostasis. We previously showed that treatment of Mecp2 mice with statin drugs alleviated motor symptoms and improved health and longevity. Lipid metabolism is a highly treatable target; therefore, our results shed light on new metabolic pathways for treatment of Rett syndrome

  8. Based on these findings, the authors suggest that MeCP2 recognition of methylated/hydroxymethylated CpA (zeige CPA1 Proteine) dinucleotides functions as an epigenetic switch redistributing MeCP2 among mCG and mCA (zeige RSPH1 Proteine) loci.

  9. Following the recent demonstration of phenotype reversal in a mouse model of MECP2 Duplication, a clear understanding of the natural history is crucial to the design and implementation of future therapeutic strategies.

  10. we could not find any significant correlation between specific MECP2 mutations and individual clinical features or global clinical score in Rett syndrome patients

Mouse (Murine) Methyl CpG Binding Protein 2 (MECP2) Interaktionspartner

  1. these findings demonstrate that increasing MeCP2 T158M protein expression is sufficient to mitigate Rett syndrome-like phenotypes and support the targeting of MeCP2 T158M expression or stability as an alternative therapeutic approach.

  2. Loss of Mecp2 is associated with Rett syndrome.

  3. Mice that lacked Mecp2 in macrophages displayed spontaneous obesity, which was linked to impaired function of brown adipose tissue (BAT (zeige BAAT Proteine)). Specifically, mutagenesis of a BAT (zeige BAAT Proteine)-resident Cx3Cr1 (zeige CX3CR1 Proteine)+ macrophage subpopulation compromised homeostatic thermogenesis but not acute, cold-induced thermogenesis. This was associated with diminished sympathetic innervation and local titers of norepinephrine.

  4. that histone deacetylase 3 (zeige HDAC3 Proteine) interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (zeige FOXO3 Proteine) deacetylation, and disruption of HDAC3 (zeige HDAC3 Proteine) contributes to cognitive and social impairment

  5. provide new insight into the upstream regulation of Sap90/Psd95 (zeige DLG4 Proteine)-associated protein 3 (zeige HSPB3 Proteine) and establish the essential role of striatal Hdac1 (zeige HDAC1 Proteine), Hdac2 (zeige HDAC2 Proteine) and MeCP2 for suppression of repetitive behaviors

  6. These findings position MeCP2 as a novel component in metabolic homeostasis. We previously showed that treatment of Mecp2 mice with statin drugs alleviated motor symptoms and improved health and longevity. Lipid metabolism is a highly treatable target; therefore, our results shed light on new metabolic pathways for treatment of Rett syndrome

  7. MeCP2 dysfunction in excitatory neurons mediated elevated synchrony at baseline, while MeCP2 dysfunction in inhibitory neurons increased susceptibility to hypersynchronization in response to perturbations.

  8. Loss of MeCP2 causes urological dysfunction and contributes to death by kidney failure in a mouse model of Rett syndrome.

  9. MeCP2 expression in the medullary respiratory network is sufficient for normal respiratory rhythm and preventing apnea. MeCP2 expression in the HoxA4 (zeige HOXA4 Proteine) domain alone is critical for survival.

  10. Mecp2 is responsive to neuronal stimulation and IGF1, and different stimuli have different effects on Mecp2 expression; this differential response may have downstream effects on functional mechanisms regulating brain development and plasticity.

Zebrafish Methyl CpG Binding Protein 2 (MECP2) Interaktionspartner

  1. A mecp2-null allele mutation zebrafish model is developed and the animals are viable and fertile.

Methyl CpG Binding Protein 2 (MECP2) Protein Überblick

Protein Überblick

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Alternative names and synonyms associated with Methyl CpG Binding Protein 2 (MECP2)

  • methyl CpG binding protein 2 (Rett syndrome) (MECP2)
  • methyl CpG binding protein 2 (Mecp2)
  • methyl CpG binding protein 2 (mecp2)
  • methyl CpG binding protein 2 (Rett syndrome) (mecp2)
  • 1500041B07Rik Protein
  • AUTSX3 Protein
  • BB130002 Protein
  • D630021H01Rik Protein
  • Mbd5 Protein
  • MRX16 Protein
  • MRX79 Protein
  • MRXS13 Protein
  • MRXSL Protein
  • PPMX Protein
  • RS Protein
  • RTS Protein
  • RTT Protein
  • WBP10 Protein
  • wu:fk96a04 Protein
  • zgc:111857 Protein

Bezeichner auf Proteinebene für MECP2

meCp-2 protein , methyl-CpG-binding protein 2 , meCP-2 protein , methyl-CpG-binding protein MeCP2

GENE ID SPEZIES
4204 Homo sapiens
17257 Mus musculus
29386 Rattus norvegicus
335250 Danio rerio
100328751 Oryctolagus cuniculus
398087 Xenopus laevis
612973 Canis lupus familiaris
539629 Bos taurus
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