Interleukin 6 Proteine (IL6)

Bezeichnung:
Interleukin 6 Proteine (IL6)
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Synonyme:
BSF2, CHIL-6, HGF, HSF, IFNB2, IL-6, il6, ILg6
alle Proteine anzeigen Gen GeneID UniProt
IL6 16193 P08505
Ratte IL6 IL6 24498 P20607
IL6 3569 P05231

Weitere Synonyme anzeigen

Interleukin 6 Proteine (IL6) nach Spezies

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Am meisten referenzierte Interleukin 6 Proteine

  1. Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305110 : Chiu, Moulds, Coffman, Rennick, Lee: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. in Proceedings of the National Academy of Sciences of the United States of America 1988 (PubMed)
    Zeige alle 5 Referenzen für 1305110

  2. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305109 : Prussin, Metcalfe: Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. in Journal of immunological methods 1996 (PubMed)
    Zeige alle 5 Referenzen für 1305109

  3. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2002764 : Kishimoto, Akira, Narazaki, Taga: Interleukin-6 family of cytokines and gp130. in Blood 1995 (PubMed)
    Zeige alle 4 Referenzen für 2002764

  4. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305111 : Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991 (PubMed)
    Zeige alle 4 Referenzen für 1305111

  5. Rhesus Monkey Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2009972 : Heinrich, Behrmann, Müller-Newen, Schaper, Graeve: Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. in The Biochemical journal 1998 (PubMed)
    Zeige alle 3 Referenzen für 2009972

  6. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2007389 : Chung, Seo, Hur, Kim, Kim, Jung, Kim, Park, Shin: Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. in Journal of human genetics 2003 (PubMed)
    Zeige alle 3 Referenzen für 2007389

  7. Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1525747 : Andrianjafiniony, Dupré-Aucouturier, Letexier, Couchoux, Desplanches: Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading. in American journal of physiology. Cell physiology 2010 (PubMed)

  8. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1878195 : Fan, Ren, Zhu, Zhang, Zhu: A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. in Biosensors & bioelectronics 2014 (PubMed)

Weitere Proteine zu Interleukin 6 Interaktionspartnern

Mouse (Murine) Interleukin 6 (IL6) Interaktionspartner

  1. IL-6 directly increases IL-10 (zeige IL10 Proteine) production and participates in the counter-inflammatory response after acute kidney injury.

  2. This work demonstrates that autocrine IL-6 signaling in the gut (zeige GUSB Proteine) epithelium regulates crypt homeostasis through the Paneth cells and the Wnt (zeige WNT2 Proteine) signaling pathway.

  3. Early and direct IL-6 signals to memory CD4 (zeige CD4 Proteine) T cells are required to program maximal secondary effector responses at the site of infection during heterosubtypic challenge, indicating a novel role for a costimulatory cytokine in recall responses.

  4. 6 h post injury, IL-6 mRNA expression was significantly lower in diabetic wounds. Abnormal macrophage activation, but not the lower abundance of CD68 (zeige CD68 Proteine)-expressing macrophages, was found to be characteristic of diabetic wounds. IL-6 played a key role in facilitating non-diabetic fibroblast migration during wound healing via the p38 MAPK (zeige MAPK14 Proteine)-Akt (zeige AKT1 Proteine) pathway. This signaling pathway was found to be dysfunctional in diabetic fibroblasts

  5. Social isolation also increased IL-6 levels in the medial prefrontal cortex, and administration of an IL-6 inhibitor (ND50 = 0.01-0.03 mug for 0.25 ng/ml IL-6) ameliorated remyelination impairments

  6. Adipose-derived stem cells play a pro-malignant role in tumor development of Lewis lung carcinoma cells by particularly promoting cancer stem cell property through interleukin-6 paracrine circuit.

  7. Absence of IL-6 did not affect overall pathogenesis of Bacillus cereus endophthalmitis.

  8. SorLA (zeige SORL1 Proteine) ectodomain, released from the cell membrane upon enzymatic cleavage of full-length SorLA (zeige SORL1 Proteine), may act as an IL-6 carrier protein that stabilizes IL-6 and its capacity for trans signaling.

  9. These findings suggest that downregulation of miR (zeige MLXIP Proteine)-142-3p in macrophages of aged mice might contribute to IL-6-associated aging disorders and that epigenetic modification might be involved in age-related inflammatory diseases.

  10. IL-6 can directly induce the transition of HSCs toward myofibroblast-like cells. The effect is mediated by the activation of both MAPK (zeige MAPK1 Proteine) and JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling pathways. Elimination of either MAPK (zeige MAPK1 Proteine) or JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling pathways inhibits HSC (zeige FUT1 Proteine) stimulation

Human Interleukin 6 (IL6) Interaktionspartner

  1. Results show that SDF-1 and IL-6 expression level is regulated by CHEK2 in breast stromal fibroblasts.

  2. Minor allele of rs1800795 and rs2069837 of Il-6 gene and its interaction were associated with increased cervical cancer risk.

  3. miR (zeige MLXIP Proteine)-146a, miR (zeige MLXIP Proteine)-146b, and miR (zeige MLXIP Proteine)-155 are exerting anti-inflammatory properties by down-regulating IL-6 and IL-8 (zeige IL8 Proteine), and influencing the expression of HSP10 (zeige HSPE1 Proteine) in the activated endothelium

  4. GG SNP at IL-6: rs1800795 may indicate an increased risk of metastasis of primary breast cancer.

  5. TNFalpha (zeige TNF Proteine) significantly increased LIF (zeige LIF Proteine) expression in uncontrolled asthma. A similar trend was observed regarding IL-6.

  6. These data suggest that, without infection, inactivated-H5N1 induces mRNA expression of IL-6 and CXCL8 (zeige IL8 Proteine) by a mechanism, or mechanisms, requiring interaction between viral hemagglutinin (zeige HA Proteine) and alpha-2,3 sialic acid receptors at the cell membrane of host cells, and involves activation of P2Y6 (zeige P2RY6 Proteine) purinergic receptors.

  7. IL-6 SNPs were associated with pulmonary tuberculosis with co-morbid diabetes in patients and their household contacts.

  8. DEK correlates with IL6 expression in HPV16+/p16+ oropharyngeal squamous cell carcinomas (OPSCC).

  9. Peritoneal membrane dysfunction in long-term peritoneal dialysis patients may result from IL-6 promotion of epithelial-to-mesenchymal transition of human peritoneal mesothelial cells possibly through the JAK2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine) signaling pathway.

  10. The associations of diabetes, combined with the polymorphisms in the genes of fat mass and obesity-associated (zeige FTO Proteine) gene (FTO (zeige FTO Proteine)), interleukin 6 (IL-6), and heat shock protein 60 (HSPD1 (zeige HSPD1 Proteine)), with breast cancer risk and survival in a Chinese Han population, was evaluated.

Cow (Bovine) Interleukin 6 (IL6) Interaktionspartner

  1. when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.

  2. The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.

  3. Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1 (zeige NR3C1 Proteine). TNF (zeige TNF Proteine) and IL6 levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.

  4. Testicular IL-1 alpha (zeige IL1A Proteine) and IL-1 beta (zeige IL1B Proteine) concentrations were highest in the early post-natal period; however, IL-1 (zeige IL1A Proteine) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.

  5. The results showed that the expression of TNF-alpha (zeige TNF Proteine), iNOS (zeige NOS2 Proteine), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (zeige IL12A Proteine) was unaffected.[IL-6, IL-12 (zeige IL12A Proteine)]

  6. results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1 (zeige STAT1 Proteine)/STAT3 (zeige STAT3 Proteine) proteins in bovine articular chondrocytes.

  7. Mechanical injury potentiates the catabolic effects of TNFalpha (zeige TNF Proteine) and IL-6/sIL-6R in causing proteoglycan (zeige Vcan Proteine) degradation in human and bovine cartilage.

Rabbit Interleukin 6 (IL6) Interaktionspartner

  1. Mild heat shock increased the production of inflammatory cytokines, IL-1beta (zeige IL1B Proteine) and IL-6 in rabbit cornea cells.

Pig (Porcine) Interleukin 6 (IL6) Interaktionspartner

  1. we showed that IL-6 did not directly promote the proliferation of theca interna cells.

  2. Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1 (zeige HIF1A Proteine)-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.

  3. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (zeige TGFB1 Proteine), IL-10 (zeige IL10 Proteine), and IL-6 in ovarian follicles are reported.

  4. Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (zeige STAT3 Proteine) (signal transducer/activator of transcription (zeige STAT1 Proteine) 3) signaling pathway (including up-regulation of STAT3 (zeige STAT3 Proteine) expression/phosphorylation).

  5. LIF (zeige LIF Proteine) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.

  6. INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.

  7. interleukin-6, endothelin ET-1 (zeige EDN1 Proteine), and apoptotic Bak (zeige BAK1 Proteine) and Bcl-XL (zeige BCL2L1 Proteine) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury

  8. Data show that all five molecules, BNP, ICAM-1 (zeige ICAM1 Proteine), TNF-alpha (zeige TNF Proteine), VCAM-1 (zeige VCAM1 Proteine) and IL-6, quickly and reliably signaled adverse interactions.

  9. IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.

  10. These results suggest that TNF-alpha (zeige TNF Proteine) and IL-10 (zeige IL10 Proteine), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.

Goat Interleukin 6 (IL6) Interaktionspartner

  1. Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.

Horse (Equine) Interleukin 6 (IL6) Interaktionspartner

  1. These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.

  2. IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (zeige WNT2 Proteine) signaling pathway transactivator beta-catenin (zeige CTNNB1 Proteine), induced expression of inhibitors of the Wnt (zeige WNT2 Proteine) pathway, and increased expression of GDF-5 (zeige GDF5 Proteine).

  3. study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (zeige ADORA2B Proteine) activation and that this effect can be modulated by A2AAR (zeige ADORA2A Proteine)

  4. Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.

  5. Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.

  6. Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (zeige IL10 Proteine) alone, were useful diagnostic indices of sepsis in equine neonates.

  7. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (zeige IL10 Proteine) and TNF-alpha (zeige TNF Proteine), in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Rainbow Trout (Oncorhynchus mykiss) Interleukin 6 (IL6) Interaktionspartner

  1. IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.

  2. in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout

  3. found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (zeige KRT12 Proteine)), are potent inducers of IL-1beta (zeige IL1B Proteine) and IL-6 gene expression and were equal to, or more potent than, crude LPS (zeige IRF6 Proteine).

Interleukin 6 (IL6) Protein Überblick

Protein Überblick

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.

Alternative names and synonyms associated with Interleukin 6 (IL6)

  • interleukin 6 (Il6)
  • interleukin 6 (interferon, beta 2) (IL6)
  • interleukin-6 (il-6)
  • BSF2 Protein
  • CHIL-6 Protein
  • HGF Protein
  • HSF Protein
  • IFNB2 Protein
  • IL-6 Protein
  • il6 Protein
  • ILg6 Protein

Bezeichner auf Proteinebene für Interleukin 6 Proteine (IL6)

B-cell hybridoma growth factor , interleukin HP-1 , interleukin-6 , IL-6 , Interleukin 6 (interferon, beta 2) , B-cell differentiation factor , B-cell stimulatory factor 2 , BSF-2 , CDF , CTL differentiation factor , IFN-beta-2 , hybridoma growth factor , interferon beta-2 , interleukin BSF-2 , Anpl-IL*06-01 , interleukin-6 protein , interferon-beta-2

GENE ID SPEZIES
16193 Mus musculus
24498 Rattus norvegicus
3569 Homo sapiens
443406 Ovis aries
395337 Gallus gallus
280826 Bos taurus
403985 Canis lupus familiaris
101798321 Anas platyrhynchos
100008733 Oryctolagus cuniculus
399500 Sus scrofa
517016 Bos taurus
100860785 Capra hircus
100034196 Equus caballus
493687 Felis catus
705819 Macaca mulatta
101281783 Orcinus orca
100136689 Oncorhynchus mykiss
503562 Takifugu rubripes
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