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Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305109
Chiu, Moulds, Coffman, Rennick, Lee: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. in Proceedings of the National Academy of Sciences of the United States of America 1988
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Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305110
Van Snick, Cayphas, Szikora, Renauld, Van Roost, Boon, Simpson: cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. in European journal of immunology 1988
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Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305111
Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991
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Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1878195
Fan, Ren, Zhu, Zhang, Zhu: A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. in Biosensors & bioelectronics 2014
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1589641
Poli, Asperti, Ruzzenenti, Mandelli, Campostrini, Martini, Di Somma, Maccarinelli, Girelli, Naggi, Arosio: Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo. in Biochemical pharmacology 2014
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2002764
Kishimoto, Akira, Narazaki, Taga: Interleukin-6 family of cytokines and gp130. in Blood 1995
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Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1525747
Andrianjafiniony, Dupré-Aucouturier, Letexier, Couchoux, Desplanches: Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading. in American journal of physiology. Cell physiology 2010
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN803874
Tan, Li, Rajendran, Kumar, Hui, Sethi et al.: Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis ... in The Journal of pharmacology and experimental therapeutics 2010
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN935536
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
HDAC3 (zeige HDAC3 Proteine)-deficient chondrocytes exhibited increased expression of cytokine and matrix-degrading genes (Il-6, Mmp3 (zeige MMP3 Proteine), Mmp13 (zeige MMP13 Proteine), and Saa3 (zeige SAA3 Proteine)) and a reduced abundance of genes related to extracellular matrix production, bone development, and ossification (Acan (zeige ACAN Proteine), Col2a1 (zeige COL2A1 Proteine), Ihh (zeige IHH Proteine), and Col10a1 (zeige COL10A1 Proteine)).
Our study is the first to show the important role of IL-6 in regulating cardiac pathogenesis via inflammation and apoptosis during AngII-induced hypertension. We also provide a novel link between IL-6/STAT3 (zeige STAT3 Proteine) and EndoG (zeige ENDOG Proteine)/MEF2A (zeige MEF2A Proteine) pathway that affects cardiac hypertrophy during AngII stimulation.
It enhances hepatic ketogenesis via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38 (zeige CRK Proteine)/nuclear factor kappaB p65 (zeige NFkBP65 Proteine).
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27 (zeige IL27 Proteine)
results suggest that IL-6 plays an important but limited role in AAA (zeige AAAS Proteine) pathogenesis, and primarily regulates cell migration and infiltration
The analysis points to a critical role for Hoxa9 (zeige HOXA9 Proteine) and PU.1 in distal regulation of c-myb (zeige MYB Proteine) expression in murine myeloid cells during iL-6-induced cell differentiation.
these findings suggested that IL6 gene deficiency antagonized HFD-induced bone loss.
Long-term exposure to atmospheric particulates, PM2.5 up-regulated H3K4 and H3K9 methylation in IL-6 and IFN-beta (zeige IFNB1 Proteine) promoter regions through down-regulating Kdm6a (zeige KDM6A Proteine) expression. The results suggest that short-term exposure to PM2.5 significantly enhances the survival rate of influenza A-contaminated mice, while long-term PM2.5 inhalation lowers the capacity of pulmonary macrophages to secrete IL-6 and IFN-beta (zeige IFNB1 Proteine).
This study suggests direct stimulation of autophagy as a novel mechanism for IL-6-mediated protection of beta cells from stress-induced apoptosis.
Internalized CpG oligodeoxynucleotide (ODN)-conjugated PPMs (PPM-CpG) greatly enhance the induction of selected cytokines (TNF-alpha (zeige TNF Proteine) and IL-6) in RAW 264.7 cells compared to that by the soluble CpG ODN and ionic complexes.
Interleukin-6 is a potential biomarker for the differential diagnosis of bacterial meningitis.
IL-6 and TIE2 (zeige TEK Proteine) polymorphisms are associated with baseline peritoneal transport property.
IL6 and PRG4 (zeige PRG4 Proteine) represent potential novel tissue biomarkers of disease severity and prognosis in conjunctival fibrosis after glaucoma surgery.
Results showed that IL-6 promoter regulates the transcription of RelA (zeige NFkBP65 Proteine) with phosphosites pSer42 and pSer45 seems to play a role in this regulation.
The levels of IL-1 (zeige IL1A Proteine), IL-6 and TNF-alpha (zeige TNF Proteine) in GCF (zeige GUCY2F Proteine) were higher in patients with ischemic stroke but the difference was not significant. In conclusion, ischemic stroke was found to be associated with higher levels of IL-1beta (zeige IL1B Proteine) and IL-6 in serum
These results support the emerging potential of CaSR (zeige CASR Proteine) as a therapeutic target in metastatic breast cancer whose pharmacological modulation would reduce IL-6.
IL6 expression was significantly higher in the cortex of asphyctic suicide subjects than in non-suicidal asphyxia and controls.
The gene polymorphism of Interleukin-6 -174 C and G allele are an risk factor for diabetes, but gene polymorphism of Interleukin-6 -174 G > C is not an independent risk factor for diabetic foot.
The expression of IL-1beta (zeige IL1B Proteine) and IL-6 during leprosy reactions did not differ significantly between tissues obtained from leprosy patients with and without HIV coinfection.
Elevated levels of systemic IFNgamma and IL-6 implied that the CEACAM5 (zeige CEACAM5 Proteine)-specific T cells had undergone immune activation in vivo but only in patients receiving high-intensity pre-conditioning.
STA3 (zeige ARHGEF3 Proteine) facilitates TLR4 (zeige TLR4 Proteine)-dependent IL-6 and IL-8 (zeige IL8 Proteine) production via IL-6 receptor-positive feedback in endometrial cells.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1 (zeige NR3C1 Proteine). TNF (zeige TNF Proteine) and IL6 levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.
Testicular IL-1 alpha (zeige IL1A Proteine) and IL-1 beta (zeige IL1B Proteine) concentrations were highest in the early post-natal period; however, IL-1 (zeige IL1A Proteine) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha (zeige TNF Proteine), iNOS (zeige NOS2 Proteine), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (zeige IL12A Proteine) was unaffected.[IL-6, IL-12 (zeige IL12A Proteine)]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1 (zeige STAT1 Proteine)/STAT3 (zeige STAT3 Proteine) proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha (zeige TNF Proteine) and IL-6/sIL-6R in causing proteoglycan (zeige Vcan Proteine) degradation in human and bovine cartilage.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta (zeige IL1B Proteine) and IL-6 in rabbit cornea cells.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1 (zeige HIF1A Proteine)-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (zeige TGFB1 Proteine), IL-10 (zeige IL10 Proteine), and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (zeige STAT3 Proteine) (signal transducer/activator of transcription (zeige STAT1 Proteine) 3) signaling pathway (including up-regulation of STAT3 (zeige STAT3 Proteine) expression/phosphorylation).
LIF (zeige LIF Proteine) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
interleukin-6, endothelin ET-1 (zeige EDN1 Proteine), and apoptotic Bak (zeige BAK1 Proteine) and Bcl-XL (zeige BCL2L1 Proteine) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP, ICAM-1 (zeige ICAM1 Proteine), TNF-alpha (zeige TNF Proteine), VCAM-1 (zeige VCAM1 Proteine) and IL-6, quickly and reliably signaled adverse interactions.
IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.
These results suggest that TNF-alpha (zeige TNF Proteine) and IL-10 (zeige IL10 Proteine), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (zeige WNT2 Proteine) signaling pathway transactivator beta-catenin (zeige CTNNB1 Proteine), induced expression of inhibitors of the Wnt (zeige WNT2 Proteine) pathway, and increased expression of GDF-5 (zeige GDF5 Proteine).
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (zeige ADORA2B Proteine) activation and that this effect can be modulated by A2AAR (zeige ADORA2A Proteine)
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (zeige IL10 Proteine) alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (zeige IL10 Proteine) and TNF-alpha (zeige TNF Proteine), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (zeige KRT12 Proteine)), are potent inducers of IL-1beta (zeige IL1B Proteine) and IL-6 gene expression and were equal to, or more potent than, crude LPS (zeige IRF6 Proteine).
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
B-cell hybridoma growth factor
, interleukin HP-1
, Interleukin 6 (interferon, beta 2)
, B-cell differentiation factor
, B-cell stimulatory factor 2
, CTL differentiation factor
, hybridoma growth factor
, interferon beta-2
, interleukin BSF-2
, interleukin-6 protein