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Authors propose a proapoptotic role for NP in IAV pathogenesis, whereby it suppresses expression of antiapoptotic factor API5, thus potentiating the E2F1 (zeige E2F1 Proteine)-dependent apoptotic pathway and ensuring viral replication.
Authors show that API5 increases the metastatic capacity of cervical cancer cells in vitro and in vivo via up-regulation of MMP-9 (zeige MMP9 Proteine).
rs17684886 (ZNRF1 (zeige ZNRF1 Proteine)) and rs599019 (COLEC12 (zeige COLEC12 Proteine)) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1 (zeige GORAB Proteine)) and rs899036 (API5) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes
API5 overexpression promoted cell proliferation and colony formation in CaSki cancer cells, whereas API5 knockdown inhibited the both properties in HeLa cells; API5 expression is associated with pERK1/2 in a subset of cervical cancer patients and its expression predicts poor overall survival.
miR (zeige MLXIP Proteine)-143 and miR (zeige MLXIP Proteine)-145 and the predicted target proteins API5, ERK5 (zeige MAPK7 Proteine), K-RAS (zeige HRAS Proteine), and IRS-1 (zeige IRS1 Proteine) display regional differences in expression in the colon
Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells.
API5 acts as an immune escape gene in tumors by rendering them resistant to apoptosis triggered by tumor antigen-specific T cells.
Low miR (zeige MLXIP Proteine)-224 and high API5 expression correlated with worse survival of glioblastoma patients.
Api5, even if not physically interacting with E2F1 (zeige E2F1 Proteine), contributes positively to E2F1 (zeige E2F1 Proteine) transcriptional activity by increasing E2F1 (zeige E2F1 Proteine) binding to its target promoters.
structure and function of API5
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
apoptosis inhibitor 5
, Apoptosis inhibitor 5-A
, Apoptosis inhibitor 5
, apoptosis inhibitor 5-like
, antiapoptosis clone 11 protein
, cell migration-inducing gene 8 protein
, fibroblast growth factor 2-interacting factor 2
, migration-inducing protein MIG8
, apoptosis inhibitory protein 5