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anti-Rat (Rattus) Glutaminase Antikörper:
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Human Monoclonal Glutaminase Primary Antibody für IF, ELISA - ABIN561056
Unterluggauer, Mazurek, Lener, Hütter, Eigenbrodt, Zwerschke, Jansen-Dürr: Premature senescence of human endothelial cells induced by inhibition of glutaminase. in Biogerontology 2008
Show all 4 Pubmed References
Human Polyclonal Glutaminase Primary Antibody für ICC, IF - ABIN4314688
Tanaka, Sasayama, Irino, Takata, Nagashima, Satoh, Kyotani, Mizowaki, Imahori, Ejima, Masui, Gini, Yang, Hosoda, Sasaki, Mischel, Kohmura: Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment. in The Journal of clinical investigation 2015
Human Polyclonal Glutaminase Primary Antibody für ELISA, WB - ABIN561055
Shajahan-Haq, Cook, Schwartz-Roberts, Eltayeb, Demas, Warri, Facey, Hilakivi-Clarke, Clarke: MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer. in Molecular cancer 2014
Dog (Canine) Polyclonal Glutaminase Primary Antibody für WB - ABIN2786054
Sahai: Glutaminase in human platelets. in Clinica chimica acta; international journal of clinical chemistry 1983
Gls is a novel ERRalpha (zeige ESRRA Antikörper) target gene.
ZIC5 (zeige ZIC5 Antikörper) positively regulated the proliferation, migration (Fig. 2), and survival (Fig. 5) of PCa (zeige FLVCR1 Antikörper) and CRC (zeige CALR Antikörper) cells
the crystal structure of full-length KGA and present a small-angle X-ray scattering model for full-length GLS2 (zeige GLS2 Antikörper). These structures explain these proteins' compromised ability to assemble into catalytically active supra-tetrameric filaments, as previously shown for GAC.
GLS1 inhibition using BPTES reduced metabolic intermediates including thymidine and carbamoyl phosphate. Reduction of thymidine and carbamoyl-phosphate synthesis by BPTES treatment exacerbated pyrimidine supply by combination with 5-FU, which induced cell death synergistically in NSCLC
studies show that the formation of large GAC oligomers is not a pre-requisite for full enzymatic activity. They also offer a mechanism by which the binding of activators like inorganic phosphate enables the activation loop to communicate with the active site to ensure maximal rates of catalysis, and promotes the opening of the lid to achieve optimal product release.
Glutaminase expression in tumor cells was significantly associated with a low level of tumor-infiltrating lymphocytesand poor disease-free survival in triple-negative breast cancers presenting with lymph node metastasis and high levels of tumor-infiltrating lymphocytes.
Study reports that GLS1 is a direct target of miR (zeige MLXIP Antikörper)-23a in retinal pigment epithelium cells (RPE (zeige RPE Antikörper)) providing evidence for a role in maintaining RPE (zeige RPE Antikörper) cell function.
The relative expression of microRNA-153 and glutaminase in glioblastoma versus matched non-tumor tissues showed a reverse correlation, further indicating that microRNA-153 may negatively regulate glutaminase in vivo.
High GLS1 expression is associated with epithelial-mesenchymal transition in cancer.
Data suggest that glutaminase C (GAC) inhibition maybe a potential treatment strategy for acquired erlotinib-resistant non-small cell lung cancer (NSCLC).
Our results suggested that glutamine (zeige GFPT1 Antikörper) metabolism is involved in the pathogenesis of rheumatoid arthritis and that GLS1 plays an important role in regulating rheumatoid arthritis fibroblast-like synoviocyte proliferation
Gls2 (zeige GLS2 Antikörper) expression is regulated by the dietary protein/carbohydrate ratio. This effect was not observed in Ppara (zeige PPARA Antikörper)-null mice.
Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.
findings suggest that glutaminase Heterozygote mice have a pro-cognitive profile in the trace fear conditioning paradigm, and this phenotype involves activation of both hippocampus and Anterior Cingulate Cortex.
studies demonstrate that GLS is required for tumorigenesis and support small molecule and genetic inhibition of GLS as potential approaches for targeting the tumor cell-autonomous dependence on GLS for cancer therapy.
The Phosphate-Activated Glutaminase (zeige GLS2 Antikörper)(PAG (zeige PRDX1 Antikörper)) is mainly active in mouse kidney, brain and liver, and shows different kinetics depending on which type of PAG (zeige PRDX1 Antikörper) is expressed.
The network identified in glutaminase deficient fetal mouse brain involves (a) cellular assembly and organization and (b) cell signaling and cell cycle, suggesting that Gls is crucial for neuronal maturation.
kidney-type glutaminase (KGA) as a novel partner of Bmcc1s
The up-regulation of neuronal glutaminase was demonstrated in situ in a murine model of HIV-1 encephalitis.
The memory deficits observed in nemy are because of reduced function of CytB561 (zeige CYB561 Antikörper) in specific brain regions that are involved in learning and memory.
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants.
, L-glutamine amidohydrolase
, glutaminase kidney isoform, mitochondrial
, glutaminase C
, phosphate-activated glutaminase
, glutaminase, phosphate-activated
, hypothetical protein
, glutaminase liver isoform, mitochondrial
, liver mitochondrial glutaminase