AGO2 Proteine (EIF2C2)

Eukaryotic Translation Initiation Factor 2C, 2 Proteine (EIF2C2)
Auf finden Sie aktuell 17 Eukaryotic Translation Initiation Factor 2C, 2 (EIF2C2) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen AGO2 Antikörper (74) und AGO2 Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 102 AGO2 Produkte verfügbar.
1110029L17Rik, 2310051F07Rik, AG02, ago, ago-2, AGO 2, ago2, AI225898, AL022874, Argonaute2, argonaute 2, AW546247, CG7439, CG13452, dAgo2, Dm Ago2, Dmel\\CG7439, eif2c1, eIF2C2, ENSMUSG00000072493, Gerp95, Gm10365, mKIAA4215, Q10, T19E23.7, T19E23_7
alle Proteine anzeigen Gen GeneID UniProt
EIF2C2 27161 Q9UKV8
Ratte EIF2C2 EIF2C2 59117 Q9QZ81
EIF2C2 239528 Q8CJG0

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Am meisten referenzierte AGO2 Proteine

  1. Human AGO2 Protein expressed in Baculovirus infected Insect Cells - ABIN2003923 : Rand, Petersen, Du, Wang: Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. in Cell 2005 (PubMed)
    Zeige alle 6 Referenzen für 2003923

  2. Mouse (Murine) AGO2 Protein expressed in Baculovirus infected Insect Cells - ABIN2008152 : Qi, Ongusaha, Myllyharju, Cheng, Pakkanen, Shi, Lee, Peng, Shi: Prolyl 4-hydroxylation regulates Argonaute 2 stability. in Nature 2008 (PubMed)
    Zeige alle 5 Referenzen für 2008152

  3. Human AGO2 Protein expressed in Wheat germ - ABIN1352524 : Rawlings, Krishnan, Walter: Viral RNAi suppressor reversibly binds siRNA to outcompete Dicer and RISC via multiple turnover. in Journal of molecular biology 2011 (PubMed)

Weitere Proteine zu AGO2 Interaktionspartnern

Arabidopsis thaliana Eukaryotic Translation Initiation Factor 2C, 2 (EIF2C2) Interaktionspartner

  1. AGO1, AGO2 and AGO10 promoted anti-TuMV defense in a modular way in various organs, with AGO2 providing a prominent antiviral role in leaves. AGO5, AGO7 and AGO10 had minor effects in leaves.

  2. Base pairing at the 15th nucleotide of a miRNA duplex is important for miRNA sorting in both Arabidopsis AGO1 (zeige EIF2C1 Proteine) and AGO2. AGO2 favours miRNA duplexes with no middle mismatches.

  3. Complementation analyses in ago mutant plants revealed that the catalytic residues of AGO1, AGO2, and AGO7 are required to restore the defects of Arabidopsis ago1-25, ago2-1, and zip-1 (AGO7-defective) mutants, respectively.

  4. AGO2 and HEN1 (zeige HENMT1 Proteine) participate in the DCL2-mediated antiviral defense to ensure the survival of Turnip crinkle virus-infected plants at high temperature.

  5. This study reveals that miR408, which has a 5'A, regulates its target Plantacyanin through either AGO1 (zeige EIF2C1 Proteine) or AGO2.

  6. AGO1 (zeige EIF2C1 Proteine) and AGO2 are involved in defense against mutant of Cucumber mosaic virus, which act downstream the biogenesis of viral secondary siRNAs in a nonredundant and cooperative manner.

  7. Results show that AGO2-bound small RNA miR393b( *) targets a Golgi-localized SNARE (zeige NAPA Proteine) gene, MEMB12.

  8. second layer is activated when the first layer is suppressed because AGO2 is repressed by AGO1 (zeige EIF2C1 Proteine) via miR403

Human Eukaryotic Translation Initiation Factor 2C, 2 (EIF2C2) Interaktionspartner

  1. This lack of 21-3U HCV host factor activity correlated with reduced recruitment of Ago2 to the HCV S1 site. Additional experiments demonstrated strong preference for guanosine at nt 22 of miR (zeige MLXIP Proteine)-122. Our findings reveal the importance of non-templated 3 miR (zeige MLXIP Proteine)-122 modifications to its HCV host factor activity, and identify unexpected differences in miRNA requirements for host gene suppression versus RNA virus replication.

  2. Low AGO2 expression is associated with melanoma.

  3. Altogether, these data suggest that the phosphorylation state of the serine/threonine cluster is important for Argonaute-mRNA interactions.

  4. data indicates that the aberrant expression of miR (zeige MLXIP Proteine)-15b contributes to abnormal placentation by targeting argonaute 2 messenger RNA

  5. findings support a model in which an AGO2 phosphorylation cycle stimulated by target engagement regulates miRNA:target interactions to maintain the global efficiency of miRNA-mediated silencing

  6. deciphering Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR (zeige MLXIP Proteine) targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across 2200 target transcripts

  7. AGO2 immunoprecipitation revealed LATS1 as a novel proapoptotic target of miR (zeige MLXIP Proteine)-21 in T cells.

  8. The miRNA biogenesis factors, DDX17 (zeige DDX17 Proteine) and KHSRP (zeige KHSRP Proteine), regulate the protein level of Ago2 in human cells.

  9. 1174 regions within the 45S rRNA transcript that have the ability to form a perfect duplex with position 2-6 (seed sequence) of each microRNA expressed in HEK293T cells. Of these potential AGO2 binding sites, 479 occurred within experimentally verified AGO2-rRNA cross-linking sites. The ability of AGO2 to cross-link to rRNA was almost completely lost in a DICER (zeige DICER1 Proteine) knock-out cell line.

  10. this study analysed binding of miR-122/ Argonaute 2 complexes to two conserved binding sites in the 5' UTR of hepatitis C virus RNA.

Mouse (Murine) Eukaryotic Translation Initiation Factor 2C, 2 (EIF2C2) Interaktionspartner

  1. We propose that RISC-mediated inhibition of specific sets of chromatin regulators is a primary mechanism for preserving embryonic stem cell pluripotency while inhibiting the onset of embryonic developmental programs

  2. Increased AGO2 was detected in autophagy-deficient ATG5 (zeige ATG5 Proteine)-/- and ATG16 (zeige ATG16L1 Proteine)-/- mouse embryonic fibroblast cells. Chemical agents and VacA toxin, which disrupt autophagy, increased AGO2 expression in MEFs, epithelial cells lines, and human monocytes.

  3. DIS3L2 (zeige DIS3L2 Proteine) interacts with Ago2 and governs target RNA-directed miRNA degradation.

  4. Results from the liver show that, siRNA targets 3'UTR and the coding sequence (CDs (zeige ABHD5 Proteine)) of endogenous genes in the presence Ago2 but in its absence, only 3'UTR-targeted siRNA-mediated knockdown are active with the help of Ago1 (zeige EIF2C1 Proteine) and Ago3 (zeige EIF2C3 Proteine).

  5. Roquin (zeige RC3H1 Proteine) also directly binds Argonaute2, a central component of the RNA-induced silencing complex, and miR (zeige MLXIP Proteine)-146a, a microRNA that targets Icos (zeige ICOS Proteine) mRNA.

  6. Target mRNAs induce tailing and trimming on Ago2-loaded miRNAs.

  7. Mouse AGO2 binds tighter to miRNA targets than its RNAi cleavage product, even though the cleaved product contains more base pairs. By re-writing the rules for nucleic acid hybridization, Argonautes allow oligonucleotides to serve as specificity determinants with thermodynamic and kinetic properties more typical of RNA-binding proteins than of RNA or DNA.

  8. Mouse Ago2 can be expressed as a fusion protein with the maltose binding protein in a soluble and enzymatically active form, without requiring coexpression with chaperones and cleave the complementary RNA in absence of other cellular factors.

  9. This study identifies the targeting of Ago2 by miR (zeige MLXIP Proteine)-184 as an essential component of the compensatory response to regulate proliferation according to insulin (zeige INS Proteine) sensitivity.

  10. study identifies Fkbp4 and Fkbp5 as novel components of the Ago2 RISC loading complex

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 2C, 2 (EIF2C2) Interaktionspartner

  1. Mutation of T1149 or R1158 in the conserved PIWI (zeige PIWIL1 Proteine) domain causes AGO2 protein instability, but only T1149 affects RNAi activity. Mass spec analysis shows that several proteasome components co-purify with both wildtype and mutant AGO2, and knockdown of two proteasome pathway components results in AGO2 protein accumulation.

  2. We speculate that the repeated evolution of testis specificity in obscura group Ago2 genes, combined with their dynamic turnover and strong signatures of adaptive evolution, may be associated with highly derived roles in the suppression of transposable elements or meiotic drive

  3. We find there are large differences in evolutionary rates and gene turnover between pathways, and that paralogs of Ago2, Ago3, and Piwi/Aub show contrasting rates of evolution after duplication.

  4. Study shows that the Cricket Paralysis virus suppressor of RNA silencing, CrPV-1A but not B2 strongly interfere with the Ago-2-dependent miRNA silencing in Drosophila.

  5. siRNA biogenesis does not stabilize AGO2 in Drosophila.

  6. The results of this study found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan

  7. analysis of regulation of Argonaute (zeige EIF2C1 Proteine) slicer activity by guide RNA 3' end interactions with the N-terminal lobe

  8. two new nuclear roles for Ago-2: one in pre-mRNA splicing and one in transcriptional repression.

  9. Highlighting its role in antiviral defense, fly Ago2 dissociates so slowly from extensively complementary target RNAs that essentially every fully paired target is cleaved. Conversely, mouse AGO2, which mainly mediates miRNA-directed repression, dissociates rapidly and with similar rates for fully paired and seed-matched targets.

  10. Nora virus VP1 and the viral suppressor of RNAi of Cricket paralysis virus (1A) antagonized Argonaute-2 (AGO2) Slicer activity of RNA induced silencing complexes pre-loaded with a methylated single-stranded guide strand.

AGO2 (EIF2C2) Protein Überblick

Protein Überblick

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with AGO2 (EIF2C2)

  • eukaryotic translation initiation factor 2C, 2 (EIF2C2)
  • Argonaute family protein (AGO2)
  • argonaute RISC catalytic component 2 (AGO2)
  • argonaute RISC catalytic component 2 (Ago2)
  • argonaute RISC catalytic component 2 (ago2)
  • argonaute RISC catalytic subunit 2 (Ago2)
  • Argonaute 2 (AGO2)
  • 1110029L17Rik Protein
  • 2310051F07Rik Protein
  • AG02 Protein
  • ago Protein
  • ago-2 Protein
  • AGO 2 Protein
  • ago2 Protein
  • AI225898 Protein
  • AL022874 Protein
  • Argonaute2 Protein
  • argonaute 2 Protein
  • AW546247 Protein
  • CG7439 Protein
  • CG13452 Protein
  • dAgo2 Protein
  • Dm Ago2 Protein
  • Dmel\\CG7439 Protein
  • eif2c1 Protein
  • eIF2C2 Protein
  • ENSMUSG00000072493 Protein
  • Gerp95 Protein
  • Gm10365 Protein
  • mKIAA4215 Protein
  • Q10 Protein
  • T19E23.7 Protein
  • T19E23_7 Protein

Bezeichner auf Proteinebene für EIF2C2

eukaryotic translation initiation factor 2C, 2 , protein argonaute-2-like , PAZ Piwi domain protein , PPD , argonaute 2 , argonaute2 , eIF-2C 2 , eIF2C 2 , hAgo2 , protein argonaute-2 , protein slicer , GERp95 , golgi ER protein 95 kDa , Protein slicer , eukaryotic translation initiation factor 2C, 1 , Piwi/Argonaute family protein meIF2C2 , argonaute RISC catalytic component 2 , mAgo2 , eukaryotic translation initiation factor 2C 2 , Eukaryotic translation initiation factor 2C 2 , translation initiation factor eIF2C , AGO2-PB , AGO2-PC , AGO2-PE , ARGONAUTE2 , CG7439-PB , CG7439-PC , CG7439-PE , argonaute , argonaute-2

475107 Canis lupus familiaris
737376 Pan troglodytes
100082977 Ornithorhynchus anatinus
100464244 Ailuropoda melanoleuca
840016 Arabidopsis thaliana
27161 Homo sapiens
59117 Rattus norvegicus
446823 Xenopus laevis
239528 Mus musculus
404130 Bos taurus
100009457 Oryctolagus cuniculus
39683 Drosophila melanogaster
448205 Xenopus (Silurana) tropicalis
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