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p97 (zeige EIF4G2 Proteine) negatively regulates NRF2 (zeige GABPA Proteine) through the canonical pathway by extracting ubiquitylated NRF2 (zeige GABPA Proteine) from the KEAP1 (zeige KEAP1 Proteine)-CUL3 (zeige CUL3 Proteine) E3 complex.
Data suggest that dimerization of UBX domain protein 7 (UBXD7) could affect the formation of the p97 ATPase-UBXD7 complex.
a VCP mutation/knockdown-induced dysregulation in the adenine nucleotide translocase, which results in a slower rate of ADP or ATP translocation across the mitochondrial membranes.
The functional motions of p97 (zeige EIF4G2 Proteine) using symmetric normal modes have been predicted.
insights into the interactions between other SHP (zeige LAMC1 Proteine)-containing proteins and p97N
The findings of the present study indicated that VCP is very important for the proliferation and metastasis of colorectal cancer; therefore, targeting VCP and its downstream targets may represent novel therapies for the treatment of colorectal cancer.
Timely and efficient degradation of ubiquitinated IkappaB[alpha], concomitant with timely and efficient liberation of RelA (zeige NFkBP65 Proteine) from ubiquitinated IkappaB[alpha] and RelA (zeige NFkBP65 Proteine) nuclear translocation, essentially depends on the presence of functional p97/VCP.
results have revealed SUMOylation as a molecular signaling switch to regulate the distribution and functions of VCP during stress response, and suggest that deficiency in VCP SUMOylation caused by pathogenic mutations will render cells vulnerable to stress insults.
depletion of VCP enzymatic activity triggers cancer cell death in part through inadequate regulation of protein synthesis and amino acid metabolism.
new role of VCP/p97 segregase in the timely processing of ubiquitinated CSB (zeige ERCC6 Proteine) from damaged chromatin.
cellular phenotypes caused by P137L mutant expression were not isolated observations, and some other IBMPFD disease-related VCP/p97 mutations could lead to similar outcomes
results suggest that (i) NLRP3 inflammasome and local IL-1beta((+))F4/80((+))Ly6C((+)) inflammatory macrophages contribute to pathogenesis of VCP-associated myopathy
VCP (valosin-containing protein), together with its cofactor P47 (zeige MFGE8 Proteine) and the endoplasmic reticulum (ER) morphology regulator ATL1 (Atlastin-1 (zeige ATL1 Proteine)), regulates tubular ER formation
Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
Global expression profiling of VCP(R155H/+) mice identified key dysregulated signaling pathways including genes involved in the physiological system development and function, diseases and disorders, and molecular and cellular functions.
The results reveal an unexpected, crucial role of ATP consumption by VCP in determining cell fate in retinitis pigmentosa, and point to a promising new neuroprotective strategy for this currently incurable disease.
Pro(178) and Pro(183) of SelS (zeige SELS Proteine) play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress
Knockdown or chemical inhibition of p97 (zeige EIF4G2 Proteine) causes robust accumulation of USP33 (zeige USP33 Proteine) due to inhibition of its degradation
conclude that the Akt (zeige AKT1 Proteine) substrate, VCP, mediates the increased expression of iNOS (zeige NOS2 Proteine) downstream from Hsp22 (zeige HSPB8 Proteine) through an NF-kappaB (zeige NFKB1 Proteine)-dependent mechanism
Findings indicate that p97 plays a conserved role in dismantling the CMG helicase complex during different cellular events, but that distinct regulatory signals ultimately control when and where unloading takes place.
p97 is an essential regulator of DNA damage-dependent CDT1 (zeige CDT1 Proteine) destruction
CDC-48/p97 coordinates CDT-1 (zeige CDT1 Proteine) degradation with GINS chromatin dissociation to ensure faithful DNA replication
data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation
results suggest that VCP plays a mechanistic role in releasing WRNp from the nucleolus
When we introduced CDC48 antisense morpholino oligonucleotides into zebrafish embryos, the morphant embryos were lethal and showed defects in neuronal outgrowth and neurodegeneration.
CDC48 may promote cell cycling and cell proliferation via C-terminal tyrosine phosphorylation during cold acclimation in fish cells
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
transitional endoplasmic reticulum ATPase
, valosin-containing protein
, valosin containing protein
, 15S Mg(2+)-ATPase p97 subunit
, TER ATPase
, yeast Cdc48p homolog
, AAA ATPase p97
, Inv protein
, homolog of yeast cdc48
, p97 ATPase