Valosin Containing Protein Proteine (vcp)

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Synonyme:
3110001E05, ALS14, CDC48, IBMPFD, p93, p97, p97/VCP, TERA, wu:fd16d05, wu:fj63d11
alle Proteine anzeigen Gen GeneID UniProt
vcp 7415 P55072
vcp 269523 Q01853
Ratte vcp vcp 116643 P46462

Valosin Containing Protein Proteine (vcp) nach Spezies

Weitere Proteine zu Valosin Containing Protein Interaktionspartnern

Human Valosin Containing Protein (vcp) Interaktionspartner

  1. VCP removes sterically trapped Ku70/80 rings from DNA in double-strand break repair.

  2. Data suggest that AAA+ (ATPases associated with diverse cellular activities) ATPase p97 is essential to wide range of cellular functions, including endoplasmic reticulum-associated degradation, membrane fusion, NFkappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation, and chromatin-associated processes, which are regulated by ubiquitination. [REVIEW]

  3. Upon damage, p97 (zeige EIF4G2 Proteine) translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1 (zeige UBXN6 Proteine), PLAA (zeige PLAA Proteine), and the deubiquitinating enzyme YOD1 (zeige YOD1 Proteine), which we term ELDR components for Endo-Lysosomal Damage Response.

  4. Data show that inhibition of VCP/p97, or siRNA-mediated ablation of VCP/p97 impairs ultraviolet radiation (UVR)-induced RNA polymerase II (RNAPII) degradation.

  5. p97 (zeige EIF4G2 Proteine) negatively regulates NRF2 (zeige GABPA Proteine) through the canonical pathway by extracting ubiquitylated NRF2 (zeige GABPA Proteine) from the KEAP1 (zeige KEAP1 Proteine)-CUL3 (zeige CUL3 Proteine) E3 complex.

  6. Data suggest that dimerization of UBX domain protein 7 (UBXD7) could affect the formation of the p97 ATPase-UBXD7 complex.

  7. a VCP mutation/knockdown-induced dysregulation in the adenine nucleotide translocase, which results in a slower rate of ADP or ATP translocation across the mitochondrial membranes.

  8. The functional motions of p97 (zeige EIF4G2 Proteine) using symmetric normal modes have been predicted.

  9. insights into the interactions between other SHP (zeige LAMC1 Proteine)-containing proteins and p97N

  10. The findings of the present study indicated that VCP is very important for the proliferation and metastasis of colorectal cancer; therefore, targeting VCP and its downstream targets may represent novel therapies for the treatment of colorectal cancer.

Mouse (Murine) Valosin Containing Protein (vcp) Interaktionspartner

  1. Together, these results suggested that mouse mammary tumor virus Rem (zeige REM1 Proteine) uses a novel p97 (zeige EIF4G2 Proteine)-dependent, Derlin-independent retrotranslocation mechanism distinct from other pathogens to avoid signal peptide ubiquitylation and proteasomal degradation.

  2. cellular phenotypes caused by P137L mutant expression were not isolated observations, and some other IBMPFD disease-related VCP/p97 mutations could lead to similar outcomes

  3. The functional motions of p97 (zeige EIF4G2 Proteine) using symmetric normal modes have been predicted.

  4. results suggest that (i) NLRP3 inflammasome and local IL-1beta((+))F4/80((+))Ly6C((+)) inflammatory macrophages contribute to pathogenesis of VCP-associated myopathy

  5. VCP (valosin-containing protein), together with its cofactor P47 (zeige MFGE8 Proteine) and the endoplasmic reticulum (ER) morphology regulator ATL1 (Atlastin-1 (zeige ATL1 Proteine)), regulates tubular ER formation

  6. Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice

  7. Global expression profiling of VCP(R155H/+) mice identified key dysregulated signaling pathways including genes involved in the physiological system development and function, diseases and disorders, and molecular and cellular functions.

  8. The results reveal an unexpected, crucial role of ATP consumption by VCP in determining cell fate in retinitis pigmentosa, and point to a promising new neuroprotective strategy for this currently incurable disease.

  9. Pro(178) and Pro(183) of SelS (zeige SELS Proteine) play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress

  10. Knockdown or chemical inhibition of p97 (zeige EIF4G2 Proteine) causes robust accumulation of USP33 (zeige USP33 Proteine) due to inhibition of its degradation

Xenopus laevis Valosin Containing Protein (vcp) Interaktionspartner

  1. VCP removes sterically trapped Ku70/80 rings from DNA in double-strand break repair.

  2. Findings indicate that p97 plays a conserved role in dismantling the CMG helicase complex during different cellular events, but that distinct regulatory signals ultimately control when and where unloading takes place.

  3. p97 is an essential regulator of DNA damage-dependent CDT1 (zeige CDT1 Proteine) destruction

  4. CDC-48/p97 coordinates CDT-1 (zeige CDT1 Proteine) degradation with GINS chromatin dissociation to ensure faithful DNA replication

  5. data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation

Cow (Bovine) Valosin Containing Protein (vcp) Interaktionspartner

  1. results suggest that VCP plays a mechanistic role in releasing WRNp from the nucleolus

Zebrafish Valosin Containing Protein (vcp) Interaktionspartner

  1. When we introduced CDC48 antisense morpholino oligonucleotides into zebrafish embryos, the morphant embryos were lethal and showed defects in neuronal outgrowth and neurodegeneration.

  2. CDC48 may promote cell cycling and cell proliferation via C-terminal tyrosine phosphorylation during cold acclimation in fish cells

Valosin Containing Protein (vcp) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

Alternative names and synonyms associated with Valosin Containing Protein (vcp)

  • valosin containing protein (VCP)
  • valosin containing protein (Bm1_56585)
  • valosin containing protein (LOC100136246)
  • valosin containing protein (Vcp)
  • valosin containing protein (vcp)
  • valosin-containing protein (Vcp)
  • 3110001E05 Protein
  • ALS14 Protein
  • CDC48 Protein
  • IBMPFD Protein
  • p93 Protein
  • p97 Protein
  • p97/VCP Protein
  • TERA Protein
  • wu:fd16d05 Protein
  • wu:fj63d11 Protein

Bezeichner auf Proteinebene für vcp

transitional endoplasmic reticulum ATPase , valosin-containing protein , valosin containing protein , 15S Mg(2+)-ATPase p97 subunit , TER ATPase , yeast Cdc48p homolog , AAA ATPase p97 , Inv protein , homolog of yeast cdc48 , p97 ATPase

GENE ID SPEZIES
427410 Gallus gallus
6106199 Brugia malayi
100136246 Oncorhynchus mykiss
7415 Homo sapiens
269523 Mus musculus
380491 Xenopus laevis
397524 Sus scrofa
481590 Canis lupus familiaris
507345 Bos taurus
327197 Danio rerio
116643 Rattus norvegicus
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