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Human GMNN Protein expressed in Escherichia coli (E. coli) - ABIN667697
Luo, Yang, Takihara, Knoetgen, Kessel: The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. in Nature 2004
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In the absence of geminin, limited pre-replicative complex assembly was restricted to the heterochromatin by elevated cyclin A (zeige CCNA2 Proteine)-CDK (zeige CDK4 Proteine) activity.
Gem and Brm (zeige SMARCA2 Proteine) act antagonistically to modulate the EGFR (zeige EGFR Proteine)-Ras-MAPK (zeige MAPK1 Proteine) signaling pathway, by affecting Mek (zeige MAP2K1 Proteine) levels during Drosophila development
In cycling cells, Dup (zeige CDT1 Proteine) destruction is coupled to DNA replication and that increased levels of Gem balance elevated Dup (zeige CDT1 Proteine) levels to prevent pre-replicative complex reformation when Dup (zeige CDT1 Proteine) degradation fails.
Down-regulation of APC (zeige APC Proteine)/C activity results in stabilization of Geminin protein and blocks endocycle progression.
results demonstrate that geminin is required for proper Kupffer's vesicle formation and ciliogenesis, thus playing an important part in setting up left-right asymmetry.
Results from a dual-luciferase assay in HEK293 cells showed that ZDND increases the translation of geminin
These results provide proof-of-principle that preventing geminin function could prevent malignancy in tumors derived from pluripotent cells by selectively eliminating the progenitor cells with little harm to normal cells.
cell penetrating (CP) Geminin is imported into the nucleus after incorporation and also the incorporated CP-Geminin directly interacted with Cdt1 (zeige CDT1 Proteine) or Brahma (zeige SMARCA2 Proteine)/Brg1 (zeige SMARCA4 Proteine) as the same manner as Geminin
Study shows that ablation of Geminin induces massive rereplication as a result of unrestrained Cdt1 (zeige CDT1 Proteine) activity in embryonic stem cells, whereas it has no such effect in embryonic fibroblasts in which alternative regulation of Cdt1 (zeige CDT1 Proteine) activity is intact.
Maternal geminin does not regulate oogenesis and oocyte meiotic maturation, but it does control accurate DNA replication and timely cleavage of fertilized eggs.
Regulation of gene expression by geminin occurs only after pluripotent cells differentiate into cells in which geminin is not essential for viability.
Geminin is an important regulator of self-renewal and survival of enteric nervous system progenitor cells.
geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system.
these data demonstrate a requirement for Geminin for neural tube patterning and neuronal differentiation during mammalian neurulation in vivo.
geminin is required for Sox2 (zeige SOX2 Proteine) expression, and thus for the maintenance of totipotency, pluripotency and the early neural lineage.
geminin acts both like a component of the FGF4 (zeige FGF4 Proteine) signal transduction pathway that governs trophoblast proliferation and differentiation, and geminin is required to maintain endocycles.
geminin selectively couples the transcription factor forkhead box O3 (FoxO3 (zeige FOXO3 Proteine)) to HDAC3 (zeige HDAC3 Proteine), thereby specifically facilitating FoxO3 (zeige FOXO3 Proteine) deacetylation.
summarize current information on the molecular functions of Geminin and the regulatory system for Geminin protein expression, and argue for the molecular role of Geminin in cell fate determination of hematopoietic stem cells [review]
Studies indicate that geminin expression is associated with different types of cancer.
High geminin expression is associated with breast cancer.
De novo GMNN mutations cause autosomal-dominant primordial dwarfism associated with Meier-Gorlin syndrome.
Elevated Ki67 (zeige MKI67 Proteine) and geminin expression distinguish a fraction of metastatic breast carcinoma with worse prognosis.
These findings suggest that E2F (zeige E2F1 Proteine)-mediated activation of Geminin transcription is negatively regulated by Geminin through the inhibition of chromatin remodeling.
Bound Geminin prevents transition of the pre-replicative complexes to a state that is competent for initiation of DNA replication.
Selective expression of geminin during the proliferative phase of the cell cycle and its nuclear specificity increase its potential to be used as an alternative marker of proliferation in breast cancer patients.
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
, geminin protein
, geminin, DNA replication inhibitor