anti-POLB (POLB) Antikörper

Bezeichnung:
anti-Polymerase (DNA Directed), beta Antikörper (POLB)
Auf www.antikoerper-online.de finden Sie aktuell 103 Polymerase (DNA Directed), beta (POLB) Antikörper von 21 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen POLB Proteine (14) und POLB Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 130 POLB Produkte verfügbar.
Synonyme:
A430088C08Rik, DDBDRAFT_0186152, DDBDRAFT_0215784, DDBDRAFT_0232376, DDB_0186152, DDB_0215784, DDB_0232376, POLB, wu:fa97a05, zgc:109924

Meistgesuchte Reaktivitäten zu anti-POLB (POLB) Antikörper

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anti-Human POLB Antikörper:

anti-Mouse (Murine) POLB Antikörper:

anti-Rat (Rattus) POLB Antikörper:

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Am meisten referenzierte anti-POLB Antikörper

  1. Cow (Bovine) Monoclonal POLB Primary Antibody für IHC (p), IP - ABIN153073 : Fotiadou, Henegariu, Sweasy: DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line. in Cancer research 2004 (PubMed)
    Zeige alle 6 Referenzen für 153073

  2. Human Polyclonal POLB Primary Antibody für IHC (p), IHC - ABIN407651 : Dutto, Sukhanova, Tillhon, Cazzalini, Stivala, Scovassi, Lavrik, Prosperi: p21CDKN1A Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates. in PLoS ONE 2016 (PubMed)
    Zeige alle 4 Referenzen für 407651

  3. Human Monoclonal POLB Primary Antibody für IHC (p), WB - ABIN115052 : Husain, Morton, Beard, Singhal, Prasad, Wilson, Besterman: Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition. in Nucleic acids research 1995 (PubMed)
    Zeige alle 2 Referenzen für 115052

  4. Mouse (Murine) Polyclonal POLB Primary Antibody für IHC, WB - ABIN3022385 : Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. in Cell cycle (Georgetown, Tex.) 2015 (PubMed)

  5. Cow (Bovine) Polyclonal POLB Primary Antibody für IHC, WB - ABIN2786683 : Batra, Beard, Shock, Pedersen, Wilson: Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. in Molecular cell 2008 (PubMed)

Weitere Antikörper gegen POLB Interaktionspartner

Zebrafish Polymerase (DNA Directed), beta (POLB) Interaktionspartner

  1. DNA polymerase beta is sensitive to Mn2+ and Mg2 (zeige MCOLN1 Antikörper)+ and its optimumal pH is 9.

  2. In brief, the major differences in BER performed by early stage embryos and adults are the absence of DNA polymerase-beta, leading to predominance of replicative polymerases, in early stage embryos.

Human Polymerase (DNA Directed), beta (POLB) Interaktionspartner

  1. High DNA polymerase beta mRNA expression is associated with Graves' thyroid tissue.

  2. Polbeta was shown to inhibit the 3'->5' exonuclease (zeige EXOSC10 Antikörper) activity of APE1 (zeige APEX1 Antikörper) when both enzymes were added simultaneously and to insert the correct nucleotide into the gap arising after hydrolysis of AP site clustered with the benzo[a]pyrene adducts.

  3. Remote mutations induce functional changes in active site residues of human DNA polymerase beta.

  4. It has been concluded based on calculations and the experimental pH profile that the most likely path for the wild-type (WT) and the D256E and D256A mutants is a proton transfer (PT) to the bulk, although the WT may also use a PT to Asp (zeige ASIP Antikörper) 256.

  5. The homozygous/heterozygous genotypes containing the African allele showed higher POLB expression than the homozygous white allele genotype (P < .001). A replication study using a GEO data set validated all 5 eQTLs and also showed a statistically significant difference in POLB expression based on genetic ancestry (P = .002).

  6. HMGB1 (zeige HMGB1 Antikörper) stimulates activity of DNA polymerase beta on nucleosome substrates in the process of base excision repair.

  7. The results help to define the tolerance of DNA Pol beta to subtle local structural and functional alterations derived from lysine 72.

  8. PolB is ubiquitylated on amino-acid residues K206 and K244 when not in a complex with XRCC1 (zeige XRCC1 Antikörper).

  9. Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.

  10. a substitution mutation, R152C, impairs Pol beta polymerase activity and DNA base excision repair efficiency.

Mouse (Murine) Polymerase (DNA Directed), beta (POLB) Interaktionspartner

  1. pol beta plays an important role in bypassing a 5',8-cyclo-dA during DNA replication and repair.

  2. we show here that heterozygosity for a Y265C mutation in Polbeta, a key polymerase in the BER pathway, is enough to significantly reduce both the number of expansions seen in paternal gametes and the extent of somatic expansion in some tissues

  3. The aberrant DNA replication mediated by the PCNA (zeige PCNA Antikörper)-DNA pol-b complex induces p53 (zeige TP53 Antikörper)-dependent neuronal cell death

  4. Y265C POLB mutation leads to several pathologies associated with SLE and short CDR3 regions during VDJ recombination in B cells.

  5. Pol beta deficiency could enable ROS (zeige ROS1 Antikörper) accumulation.

  6. Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM (zeige CNTNAP1 Antikörper)) with no effect on mutation specificity, suggesting no direct role in SHM (zeige CNTNAP1 Antikörper).

  7. Transient OGG1 (zeige OGG1 Antikörper), APE1 (zeige APEX1 Antikörper), PARP1 (zeige PARP1 Antikörper) and Polbeta expression in an Alzheimer's disease mouse model.

  8. Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (zeige APEX1 Antikörper) and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 (zeige MBD3 Antikörper) in individual morula embryos.

  9. Overexpression of Pol beta could reduce oxidative damage and protect cells from hydroquinone genotoxicity.

  10. Polbeta could protect cells from apoptosis induced by hydroquinone through decrease of ROS (zeige ROS1 Antikörper) level and depolarization of mitochondria.

POLB Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date.

Alternative names and synonyms associated with POLB

  • polymerase (DNA directed), beta (polb) Antikörper
  • polymerase (DNA directed), beta (POLB) Antikörper
  • DNA polymerase X family protein (polB) Antikörper
  • DNA polymerase beta-like (LOC100526021) Antikörper
  • polymerase (DNA directed), beta (Polb) Antikörper
  • A430088C08Rik Antikörper
  • DDBDRAFT_0186152 Antikörper
  • DDBDRAFT_0215784 Antikörper
  • DDBDRAFT_0232376 Antikörper
  • DDB_0186152 Antikörper
  • DDB_0215784 Antikörper
  • DDB_0232376 Antikörper
  • POLB Antikörper
  • wu:fa97a05 Antikörper
  • zgc:109924 Antikörper

Bezeichner auf Proteinebene für POLB

DNA-directed DNA polymerase beta , DNA polymerase beta , polymerase (DNA directed), beta , DNA polymerase beta-like , DNA pol beta , DNA polymerase beta subunit , mutant DNA polymerase beta , Pol beta , polymerase-beta

GENE ID SPEZIES
448741 Xenopus (Silurana) tropicalis
554204 Danio rerio
704801 Macaca mulatta
737210 Pan troglodytes
8624738 Dictyostelium discoideum AX4
100348691 Oryctolagus cuniculus
100393825 Callithrix jacchus
100441812 Pongo abelii
100526021 Sus scrofa
5423 Homo sapiens
614688 Bos taurus
397973 Xenopus laevis
18970 Mus musculus
29240 Rattus norvegicus
426794 Gallus gallus
494001 Canis lupus familiaris
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