MGMT Proteine (MGMT)

O6-Methylguanine-DNA-Methyltransferase Proteine (MGMT)
Auf finden Sie aktuell 25 O6-Methylguanine-DNA-Methyltransferase (MGMT) Proteine von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MGMT Antikörper (215) und MGMT Kits (32) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 284 MGMT Produkte verfügbar.
Agat, AGT, AI267024
alle Proteine anzeigen Gen GeneID UniProt
MGMT 4255  
MGMT 17314 P26187
MGMT 25332 P24528

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Am meisten referenzierte MGMT Proteine

  1. Human MGMT Protein expressed in Escherichia coli (E. coli) - ABIN666723 : Esteller, Gaidano, Goodman, Zagonel, Capello, Botto, Rossi, Gloghini, Vitolo, Carbone, Baylin, Herman: Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. in Journal of the National Cancer Institute 2002 (PubMed)
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Weitere Proteine zu MGMT Interaktionspartnern

Human O6-Methylguanine-DNA-Methyltransferase (MGMT) Interaktionspartner

  1. Nitrogen mustard-induced MGMT-DNA crosslinking in 16HBE cells.

  2. Results show that allelic frequencies of the MGMT promoter region locus rs1625649 between patients and healthy control groups were statistically significantly different suggesting an association with the occurrence of laryngeal cancer.

  3. Combination of MGMTmethylation/IDH1 (zeige IDH1 Proteine) mutation is associated with considerably longer overall survival of chemoradiotherapy-treated glioblastoma patients.

  4. MGMT protein expression assessed by immunohistochemistry did not play an important role as a predictive marker for alkylating agents.

  5. Glioblastoma patients with high IFIT1 (zeige IFIT1 Proteine) and low MGMT expression have an improved prognosis.

  6. Glioblastoma patients with high expression of hepatocyte growth factor (zeige HGF Proteine) or unmethylated O(6)-methylguanine-DNA methyltransferase may benefit from onartuzumab plus bevacizumab chemotherapy.

  7. results demonstrate MGMT methylation is a reliable and independent prognostic factor in DAs (zeige ube3a Proteine). Methylation of MGMT is associated with poor prognosis in patients with stage III DAs (zeige ube3a Proteine)

  8. investigation of MGMT promoter methylation and in particular BRAF (zeige BRAF Proteine) V600E mutations represent reliable additional tools to sustain differentiation of Giant Cell Glioblastoma (gcGBM) from Pleomorphic Xanthoastrocytoma (PXA) on a molecular basis. Based on these data specific BRAF (zeige BRAF Proteine) kinase inhibitors could represent a promising agent in the therapy of PXA and their use should be emphasized.

  9. Efficacy of TMZ in adrenocortical carcinoma cells does not seem to be limited by low methylation of MGMT.

  10. MGMT is involved in gastric carcinogenesis via downregulation of MMP2 (zeige MMP2 Proteine).

Mouse (Murine) O6-Methylguanine-DNA-Methyltransferase (MGMT) Interaktionspartner

  1. Snell, GHKRO, and PAPPA (zeige PAPPA Proteine)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1 (zeige NDRG1 Proteine)).

  2. This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG (zeige C16orf35 Proteine), as a key node in determining a carcinogenic threshold.

  3. Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation.

  4. Loss of MGMT expression and high Ezrin (zeige EZR Proteine) protein expression leads to esophageal cancer.

  5. Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.

  6. ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.

  7. Roles of MGMT and MLH1 (zeige MLH1 Proteine) proteins in alkylation-induced apoptosis and mutagenesis.

  8. Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer

  9. GAMT (zeige GAMT Proteine) and AGAT (zeige GATM Proteine) mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx (zeige DMD Proteine) muscle compared to C57

  10. MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

MGMT Protein Überblick

Protein Überblick

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a

Alternative names and synonyms associated with MGMT

  • O-6-methylguanine-DNA methyltransferase (MGMT)
  • O-6-methylguanine-DNA methyltransferase (Mgmt)
  • Agat Protein
  • AGT Protein
  • AI267024 Protein

Bezeichner auf Proteinebene für MGMT

6-O-methylguanine-DNA methyltransferase , O-6-methylguanine-DNA-alkyltransferase , O6-methylguanine-DNA methyltransferase , methylated-DNA--protein-cysteine methyltransferase , methylguanine-DNA methyltransferase , O-6-alkylguanine-DNA alkyltransferase , 0-6-methylguanine-DNA methyltransferase , O(6)-alkylguanine-DNA alkyltransferase , O6-alkylguanine-DNA alkyltransferase , O6-methylguanine-DNA methyltranferase , O6-alkylguanine-DNA-alkyltransferase , O6-methylguanine-DNA-methyltransferase

4255 Homo sapiens
17314 Mus musculus
25332 Rattus norvegicus
100733185 Cavia porcellus
100155050 Sus scrofa
616091 Bos taurus
442978 Canis lupus familiaris
423965 Gallus gallus
101106897 Ovis aries
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