anti-MLH3 (MLH3) Antikörper

Bezeichnung:
anti-MutL Homolog 3 (E. Coli) Antikörper (MLH3)
Auf www.antikoerper-online.de finden Sie aktuell 34 MutL Homolog 3 (E. Coli) (MLH3) Antikörper von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 38 MLH3 Produkte verfügbar.
Synonyme:
AV125803, BB126472, HNPCC7, MGC80774, MLH3
Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Maus MLH3 MLH3 217716  
Anti-Ratte MLH3 MLH3 314320  
MLH3 27030 Q9UHC1

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Meistgesuchte Reaktivitäten zu anti-MLH3 (MLH3) Antikörper

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anti-Human MLH3 Antikörper:

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Am meisten referenzierte anti-MLH3 Antikörper

  1. Dog (Canine) Polyclonal MLH3 Primary Antibody für ELISA - ABIN249597 : Lipkin, Wang, Jacoby, Banerjee-Basu, Baxevanis, Lynch, Elliott, Collins: MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. in Nature genetics 2000 (PubMed)

Weitere Antikörper gegen MLH3 Interaktionspartner

Mouse (Murine) MutL Homolog 3 (E. Coli) (MLH3) Interaktionspartner

  1. these data identify Mlh1 (zeige MLH1 Antikörper) and Mlh3 as novel critical genetic modifiers of HTT (zeige HTT Antikörper) CAG instability, point to Mlh1 (zeige MLH1 Antikörper) genetic variation as the likely source of the instability difference in B6 and 129 strains

  2. Mlh3 is required for Mlh1 (zeige MLH1 Antikörper) binding to meiotic chromosomes and localizes to chromosomes from the mid pachynema stage of prophase. Mlh3(-/-) spermatocytes reach metaphase before succumbing to apoptosis, oocytes fail to complete meiosis I after fertilization.

  3. Associated with MSH4 (zeige MSH4 Antikörper) in mammalian meiotic cells, supporting the possibility that MLH3 plays a role in meiotic recombination.

  4. Data show partial functional redundancy between MLH3 and PMS2 (zeige PMS2 Antikörper) orthologues for mutation avoidance and show a role for Mlh3 in gastrointestinal and extragastrointestinal tumor suppression.

  5. Mlh3 normally inhibits the accumulation of mutations in somatic hypermutation

  6. DNA mismatch repair Mlh3 protein plays a role in both class switch DNA recombination and somatic hypermutation

  7. These results indicate that approximately 10% of crossovers in the mouse are independent of MLH3, suggesting the existence of alternative crossover pathways in mammals.

  8. Mlh3 nullizygosity significantly increased Apc (zeige APC Antikörper) frameshift mutations and tumor multiplicity.

  9. MLH3-independent crossovers in mammalian meiosis,in Mus81 (zeige MUS81 Antikörper)-nullizygous mice.

Human MutL Homolog 3 (E. Coli) (MLH3) Interaktionspartner

  1. A polymorphism within the MLH3 gene is associated with oligozoospermia in Caucasian men of a certain area.

  2. MutL homolog 3 (MLH3) promoter methylation was observed in 61% of oligoastrocytoma and 27% of astrocytoma.

  3. the MutSbeta-MutLalpha interaction is mediated in part by residues ((L/I)SRFF) embedded within the MSH3 (zeige MSH3 Antikörper) PCNA (zeige PCNA Antikörper)-binding motif

  4. hMLH3 mRNA is present at low levels in numerous tissues but high levels in testis. hMLH3 functions in meiosis as well as hMSH2 (zeige MSH2 Antikörper)-hMSH3 (zeige MSH3 Antikörper) repair processes & has little if any role in Hereditary Non-Polyposis Colorectal Cancer (HNPCC (zeige MLH1 Antikörper)).

  5. There is an association of polymorphism C85T in MSH5 (zeige MSH5 Antikörper) or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 (zeige MSH5 Antikörper) and MLH3 polymorphisms increased the risk of developing male infertility

  6. Little evidence for involvement of MLH3 in colorectal cancer predisposition.

  7. at pachynema, when chromosomes are fully paired, we find significant heterogeneity in the localization of the MutL homologs, MLH1 (zeige MLH1 Antikörper) and MLH3, among human oocyte populations

  8. The identification of inherited missense variants, somatic missense mutations (present in 3 of 57 tumors), and LOH in the tumor from a patient with a germ line missense change suggest a role for MLH3 in endometrial tumorigenesis.

  9. Mutations of Mlh3 may work together with other genes in an accumulated manner and result in an increased risk of esophageal tumor

  10. in absence of hPMS2, hMLH3 (hMutLgamma) is located in the nucleus, suggesting a conditional activity in MMR (zeige MRC1 Antikörper) and supporting its role as a low-risk gene in hereditary non-polyposis colorectal cancer

MLH3 Antigen-Profil

Beschreibung des Gens

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Alternative names and synonyms associated with MLH3

  • mutL homolog 3 (E coli) (Mlh3) Antikörper
  • mutL homolog 3 (E. coli) (Mlh3) Antikörper
  • mutL homolog 3 (mlh3) Antikörper
  • mutL homolog 3 (E. coli) (MLH3) Antikörper
  • mutL homolog 3 (LOC100339094) Antikörper
  • mutL homolog 3 (E. coli) (mlh3) Antikörper
  • AV125803 Antikörper
  • BB126472 Antikörper
  • HNPCC7 Antikörper
  • MGC80774 Antikörper
  • MLH3 Antikörper

Bezeichner auf Proteinebene für MLH3

DNA mismatch repair protein Mlh3 , mutL 3 , mutL homolog 3 , mutL homolog 3 (E. coli) , DNA mismatch repair protein Mlh3-like

GENE ID SPEZIES
217716 Mus musculus
314320 Rattus norvegicus
444223 Xenopus laevis
453043 Pan troglodytes
701482 Macaca mulatta
100171738 Pongo abelii
100339094 Oryctolagus cuniculus
100387522 Callithrix jacchus
100552500 Anolis carolinensis
100583687 Nomascus leucogenys
27030 Homo sapiens
480389 Canis lupus familiaris
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