Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human Vinculin Antikörper:
anti-Mouse (Murine) Vinculin Antikörper:
anti-Rat (Rattus) Vinculin Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal Vinculin Primary Antibody für IF (cc), IF (p) - ABIN719261
Li, Sun, Yang, Hu, Jiang: Tanshinone II a protects against lipopolysaccharides-induced endothelial cell injury via Rho/Rho kinase pathway. in Chinese journal of integrative medicine 2014
Show all 6 Pubmed References
Human Polyclonal Vinculin Primary Antibody für IHC (p), WB - ABIN3044168
Lyu, Wang, Wang, Ding, Liu, Yuan, Shi, Wang, Wang, Chen: Maintaining the pluripotency of mouse embryonic stem cells on gold nanoparticle layers with nanoscale but not microscale surface roughness. in Nanoscale 2014
Show all 3 Pubmed References
Chicken Monoclonal Vinculin Primary Antibody für IHC (fro), WB - ABIN3043674
Lyu, Hu, Xu, Zhang: Dynamics of focal adhesions and reorganization of F-actin in VEGF-stimulated NSCs under varying differentiation states. in Journal of cellular biochemistry 2013
Show all 3 Pubmed References
Bat Polyclonal Vinculin Primary Antibody für WB - ABIN611567
Hou, Schindler, Henzel, Ho, Brasseur, McKnight: An interleukin-4-induced transcription factor: IL-4 Stat. in Science (New York, N.Y.) 1994
Show all 3 Pubmed References
Amphibian Monoclonal Vinculin Primary Antibody für ICC, IHC (fro) - ABIN269480
Chianale, Cutrupi, Rainero, Baldanzi, Porporato, Traini, Filigheddu, Gnocchi, Santoro, Parolini, van Blitterswijk, Sinigaglia, Graziani: Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling. in Molecular biology of the cell 2007
Show all 4 Pubmed References
Human Monoclonal Vinculin Primary Antibody für IF, ELISA - ABIN563365
Maghdessian, Côté, Rouleau, Ben Djoudi Ouadda, Levy, Lavoie: Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig. in The Journal of pharmacology and experimental therapeutics 2010
Human Monoclonal Vinculin Primary Antibody für IP, IHC - ABIN284839
Korte, Fröhlich, Kohn, Kaspers, Arnold, Härtle: 2-D DIGE analysis of the bursa of Fabricius reveals characteristic proteome profiles for different stages of chicken B-cell development. in Proteomics 2012
Mouse (Murine) Monoclonal Vinculin Primary Antibody für IHC (fro), IHC (p) - ABIN289630
Witt, Zieseniss, Fock, Jockusch, Illenberger: Comparative biochemical analysis suggests that vinculin and metavinculin cooperate in muscular adhesion sites. in The Journal of biological chemistry 2004
The central role of talin and vinculin in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM (zeige MMRN1 Antikörper) interactions and remodeling of the tissue.
East Asian common VCL variant p.Asp841His (D841H) was associated with sudden unexplained nocturnal death syndrome (SUNDS) in the Chinese Han population.
We identified mutations in VCL associated with Short segment Hirschsprung disease. Correction of this mutation in induced pluripotent stem cells using CRISPR/Cas9 editing, as well as the RET (zeige RET Antikörper) G731del mutation that causes Hirschsprung disease with total colonic aganglionosis, restored enteric neural crest cell function.
This review discusses the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. [review]
Study predicted the structure of the MAPK1 (zeige MAPK3 Antikörper)-vinculin binding interface using a combination of flexible docking and molecular dynamics simulations, and confirmed that the MAPK1 (zeige MAPK3 Antikörper)-vinculin interaction is mechanically regulated, and implicated a change in the vinculin D3-D4 cleft size upon vinculin activation as the basis for the conformational selectivity of MAPK1 (zeige MAPK3 Antikörper) binding toward open vinculin.
These results suggest that vinculin promotes the nuclear localization of transcription factor TAZ (zeige TAZ Antikörper) to inhibit the adipocyte differentiation on rigid extracellular matrix.
The VCL-encoding protein was involved in cardiomyopathy that associated with hypertension, therefore our results suggest the rs4746172 of VCL may be a novel target for clinical interventions to reduce CVD risk by regulating blood pressure in male Chinese
Three novel genes were identified as recurrently mutated; MYCN (zeige MYCN Antikörper), MYO5B and VCL, and mutations in these genes were exclusively found in malignant sympathetic paraganglioma tumors.
roles and mechanisms of phospholipids in regulating the structure and function of vinculin and of its muscle-specific (zeige EIF3K Antikörper) metavinculin splice variant.
Upon actin engagement, the N-terminal "strap" and helix 1 are displaced from the vinculin tail helical bundle to mediate actin bundling.
Study show that zebrafish contain two homologous vinculin isoforms, of which the sequence of key functional domains is conserved with several higher vertebrate. Loss of both zygotic vcla and maternal contribution of vcla did not result in notable defects, while the additional loss of zygotic vclb is lethal only after embryonic stages. These data indicate that embryonic development in zebrafish can occur without vinculin.
Results suggest that myosin VI (zeige MYO6 Antikörper) and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia.
Lipid binding increases vinculin activation and turnover at focal adhesions.
results suggest that the vinculin-actin interaction participates in FA-mediated mechanotransduction
The results indicate that lipid rafts play an important role in extracellular matrix stiffness regulation of cell migration via expression vinculin and its interaction with vinexin alpha (zeige Sorbs3 Antikörper).
Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability.
These data demonstrate that Src-mediated phosphorylation is necessary for vinculin activation, and that phosphorylation controls cytoskeletal mechanics by regulating force transmission between the actin cytoskeleton and focal adhesion proteins.
results suggest that vinculin promotes directionally persistent cell migration and tension-dependent ECM (zeige MMRN1 Antikörper) remodeling in complex 3D environments by increasing cell-ECM (zeige MMRN1 Antikörper) adhesion and traction force generation.
Force-dependent conformational switch of alpha-catenin (zeige CTNNA1 Antikörper) controls vinculin binding.
Mutant vinculin expressing cells are altered in cell migration, which is accompanied by changes in cell adhesion.
show that Src (zeige SRC Antikörper) phosphorylation of Y1065 within the C-terminal hairpin regulates Vt-mediated actin bundling and provide a detailed characterization of vinculin Y1065 mutations
These findings demonstrate the crucial importance of the tight control of the activity of vinculin.
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
, vinculin at 2EF