anti-SPTAN1 (SPTAN1) Antikörper

Bezeichnung:
anti-Spectrin alpha Chain, Brain Antikörper (SPTAN1)
Auf www.antikoerper-online.de finden Sie aktuell 155 Spectrin alpha Chain, Brain (SPTAN1) Antikörper von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SPTAN1 Proteine (30) und SPTAN1 Kits (23) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 213 SPTAN1 Produkte verfügbar.
Synonyme:
2610027H02Rik, A2a, EIEE5, im:7157190, IPF, NEAS, SPECA, Spna-2, Spna2, SPTA2, wu:fa20e05, wu:fb33g08, wu:fk32a10, zgc:112229
Alle Antikörper anzeigen Gen GeneID UniProt
SPTAN1 20740  
SPTAN1 6709 Q13813
SPTAN1 64159 P16086

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Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-SPTAN1 (SPTAN1) Antikörper

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anti-Mouse (Murine) SPTAN1 Antikörper:

anti-Human SPTAN1 Antikörper:

anti-Rat (Rattus) SPTAN1 Antikörper:

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Am meisten referenzierte anti-SPTAN1 Antikörper

  1. Human Monoclonal SPTAN1 Primary Antibody für EIA, IHC (fro) - ABIN1109119 : McClintock, Rising, Lerner: Melanophore pigment dispersion responses to agonists show two patterns of sensitivity to inhibitors of cAMP-dependent protein kinase and protein kinase C. in Journal of cellular physiology 1996 (PubMed)
    Zeige alle 10 Referenzen für 1109119

  2. Human Polyclonal SPTAN1 Primary Antibody für ELISA, WB - ABIN1536099 : Cianci, Zhang, Pradhan, Morrow: Brain and muscle express a unique alternative transcript of alphaII spectrin. in Biochemistry 2000 (PubMed)
    Zeige alle 2 Referenzen für 1536099

  3. Cow (Bovine) Polyclonal SPTAN1 Primary Antibody für IP, IHC - ABIN2787729 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)

  4. Chicken Monoclonal SPTAN1 Primary Antibody für ChIP, IF - ABIN110976 : Ylikoski, Pirvola, Närvänen, Virtanen: Nonerythroid spectrin (fodrin) is a prominent component of the cochlear hair cells. in Hearing research 1990 (PubMed)

Weitere Antikörper gegen SPTAN1 Interaktionspartner

Zebrafish Spectrin alpha Chain, Brain (SPTAN1) Interaktionspartner

  1. AlphaII-spectrin in the axonal cytoskeleton is essential for stabilizing nascent sodium-channel clusters and assembling the mature node of Ranvier.

Mouse (Murine) Spectrin alpha Chain, Brain (SPTAN1) Interaktionspartner

  1. Fodrin is a regulatory transporter of gamma-tubulin (zeige TUBG1 Antikörper) to the centrosomes for normal progression of mitosis.

  2. Mena/VASP and alphaII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.

  3. Degradation of Spna2 by calpain- and/or caspase is not central to the pathogenesis of 1,2-diacetylbenzene (DAB) axonopathy.

  4. The present study demonstrates the age-dependent intraneuronal presence of an alphaII-spectrin cleavage fragment in mammalian forebrain which is exacerbated in a transgenic model of AD.

  5. alphaII-spectrin deficiency is embryonic lethal, with cardiac, craniofacial and neural tube malformations.

  6. Results of this study provide evidence for a role for spectrin in different steps of megakaryocyte development through its participation in the formation of invaginated membranes and in the maintenance of proplatelet structure.

  7. When cleaved into a 120-kDa product by apoptotic proteases in salivary gland cells in vitro, alpha-fodrin is a successful pathogenic autoantigen for development of autoimmune exocrinopathy in the Sjogren syndrome model.

  8. In heart muscle, alphaII-spectrin is located within the contractile fibres near the Z-disc as well as on the cardiomyocyte plasma membrane.

  9. support a critical role for the alphaII-spectrin-SH3i isoform of spectrin in intracellular targeting of connexin 43 (zeige GJA1 Antikörper) to gap junctions

  10. AlphaII-spectrin-VASP complexes regulate cortical actin cytoskeleton assembly with implications for vascular permeability.

Human Spectrin alpha Chain, Brain (SPTAN1) Interaktionspartner

  1. Alpha-spectrin is critical for recruitment of non-ubiquitinated FANCD2 (zeige FANCD2 Antikörper) to sites of damage, which has an important role in the repair response and interstrand cross-link repair.

  2. These results suggest that ubiquitin C-terminal hydrolase and alphaII-spectrin breakdown product 145 kDa may be useful in assessing outcome after pediatric traumatic brain injury.

  3. Variations in both alpha-spectrin (SPTA1 (zeige SPTA1 Antikörper)) and beta-spectrin ( SPTB (zeige SPTB Antikörper) ) were found in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis.

  4. aggressiveness of MLH1 (zeige MLH1 Antikörper)-positive colorectal cancers might be related to SPTAN1.

  5. hypomyelination of the cerebral white matter was revealed at the age of 1 year, and a de novo heterozygous mutation in the SPTAN1 gene was confirmed

  6. loss of SPTAN1 switches TGF-beta (zeige TGFB1 Antikörper) signaling from tumor suppression to tumor promotion by engaging Notch (zeige NOTCH1 Antikörper) signaling and activating SOX9 (zeige SOX9 Antikörper) in esophageal adenocarcinoma.

  7. organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta (zeige PKCd Antikörper)(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin

  8. In-frame mutations in the C-terminus of SPTAN1 cause a core set of manifestations that include severe intellectual disability, generalized epilepsy, and pontocerebellar atrophy.

  9. Analysis of alphaII-spectrin breakdown products in cerebrospinal fluid predicts mortality and injury severity in adults following traumatic brain injury.

  10. findings suggest that pathological aggregation of alpha/beta spectrin heterodimers and abnormal axon initial segment(AIS (zeige AR Antikörper)) integrity resulting from SPTAN1 mutations were involved in pathogenesis of infantile epilepsy

SPTAN1 Antigen-Profil

Beschreibung des Gens

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with SPTAN1

  • spectrin, alpha, non-erythrocytic 1 (SPTAN1) Antikörper
  • spectrin alpha 2 (spna2) Antikörper
  • Spectrin alpha chain, brain (spta2) Antikörper
  • spectrin alpha, non-erythrocytic 1 (Sptan1) Antikörper
  • spectrin, alpha, non-erythrocytic 1 (Sptan1) Antikörper
  • spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) (SPTAN1) Antikörper
  • 2610027H02Rik Antikörper
  • A2a Antikörper
  • EIEE5 Antikörper
  • im:7157190 Antikörper
  • IPF Antikörper
  • NEAS Antikörper
  • SPECA Antikörper
  • Spna-2 Antikörper
  • Spna2 Antikörper
  • SPTA2 Antikörper
  • wu:fa20e05 Antikörper
  • wu:fb33g08 Antikörper
  • wu:fk32a10 Antikörper
  • zgc:112229 Antikörper

Bezeichner auf Proteinebene für SPTAN1

alpha-fodrin , spectrin alpha chain, brain , spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) , cardiomyocyte alpha-spectrin , sequence with a GC signal , alpha2 spectrin , Spectrin alpha chain, brain , alpha-II spectrin , alpha-spectrin 2, brain , fodrin alpha chain , spectrin alpha 2 , spectrin alpha chain, non-erythrocytic 1 , spectrin, non-erythroid alpha chain , spectrin, non-erythroid alpha subunit , a--fodrin , alpha II spectrin , alpha-spectrin 2 , brain alpha-spectrin , inhibitory protein factor , noerythroid alpha-spectrin 2 , nonerythroid alpha-spectrin 2 , alpha-spectrin , nonerythroid alpha-spectrin

GENE ID SPEZIES
540108 Bos taurus
403484 Canis lupus familiaris
553383 Danio rerio
100380773 Salmo salar
20740 Mus musculus
6709 Homo sapiens
64159 Rattus norvegicus
374234 Gallus gallus
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