anti-APLP1 (APLP1) Antikörper

Bezeichnung:
anti-Amyloid beta (A4) Precursor-Like Protein 1 Antikörper (APLP1)
Auf www.antikoerper-online.de finden Sie aktuell 60 Amyloid beta (A4) Precursor-Like Protein 1 (APLP1) Antikörper von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen APLP1 Kits (9) und APLP1 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 84 APLP1 Produkte verfügbar.
Synonyme:
APLP, Aplp1_retired, MGC115336, RGD1561211
Alle Antikörper anzeigen Gen GeneID UniProt
APLP1 333 P51693
APLP1 11803 Q03157
APLP1 502317  

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anti-Human APLP1 Antikörper:

anti-Mouse (Murine) APLP1 Antikörper:

anti-Rat (Rattus) APLP1 Antikörper:

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Weitere Antikörper gegen APLP1 Interaktionspartner

Human Amyloid beta (A4) Precursor-Like Protein 1 (APLP1) Interaktionspartner

  1. These data reveal a conserved mechanism for the binding of APP (zeige APP Antikörper)-family proteins to HS and imply a specific regulatory role of HS modifications in the biology of APP (zeige APP Antikörper) and APP-like (zeige APP Antikörper) proteins.

  2. APLP1 and APLP2 (zeige APLP2 Antikörper), behave similarly to APP (zeige APP Antikörper) in that they both associate with assembled NMDA receptors in the endoplasmic reticulum

  3. CSF (zeige CSF2 Antikörper) levels of 3 endogenous peptides derived from APLP1 (APL1beta25, APL1beta27 and APL1beta28) were decreased in Down syndrome.

  4. APLP1 has a regulatory role in the nuclear translocation of APP (zeige APP Antikörper) family intracellular domains due to the sequestration of Fe65 (zeige APBB1 Antikörper).

  5. [review] APP (zeige APP Antikörper) and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2 (zeige APLP2 Antikörper), participate under physiological conditions via trans-cellular dimerization in synaptogenesis.

  6. APLP1 binds the II-III loop of the Ca(v)2.3 calcium channel and that this binding promotes internalization of the channel.

  7. Both APLP1 and APLP2 (zeige APLP2 Antikörper), form transcriptionally active triple protein complexes with Mint3 (zeige APBA3 Antikörper) and transcriptional co-activators Taz (zeige TAZ Antikörper) andYap.

  8. Human cerebrospinal fluid contains three APLP1-derived Abeta (zeige APP Antikörper)-like peptides that are generated by beta- and gamma-cleavages at a concentration of approximately 4.5 nM.

  9. APLP1 and APLP2 (zeige APLP2 Antikörper) are processed by the gamma-secretase in a Presenilin 1 (zeige PSEN1 Antikörper)-dependent manner and the extreme carboxyl-terminal fragments produced by this processing (APP-like (zeige APP Antikörper) Intracellular Domain) are able to enhance Fe65 (zeige APBB1 Antikörper)-dependent gene activation

  10. APLP1 does not undergo the same type of regulated processing as APP (zeige APP Antikörper) and APLP2 (zeige APLP2 Antikörper).

Mouse (Murine) Amyloid beta (A4) Precursor-Like Protein 1 (APLP1) Interaktionspartner

  1. APLP1 exhibits synaptogenic activity, involving trans-synaptic dimerization. APLP1 knock-out mice show impaired basal transmission and a reduced mEPSC frequency.

  2. Results suggest that APLP1 deficiency on its own does not lead to defects in synaptic plasticity, but affects synaptic transmission and network inhibition in the dentate gyrus

  3. [review] A role of APP (zeige APP Antikörper) and its two closely related homologues APLP1 and APLP2 (zeige APLP2 Antikörper) has been determined in various aspects of nervous system development and function, in particular, for synapse formation and function.

  4. findings demonstrated that NB-2 (zeige CNTN5 Antikörper) interacts with APLP and that both NB-2 (zeige CNTN5 Antikörper) and APLP1 are localized at presynaptic sites, suggesting that NB-2 (zeige CNTN5 Antikörper) associates with APLP1 in a cis (zeige CISH Antikörper) manner on the presynaptic membrane

  5. Crystal structure of the E2 domain of amyloid precursor protein-like (zeige APP Antikörper) protein 1 in complex with sucrose octasulfate.

  6. The 5' UTR (zeige UTS2R Antikörper) of the Aplp1 gene lacks any type of CAGA (zeige S100A8 Antikörper) box. This may explain its inability to form amyloid plaques.

  7. Cytoplasmic polyadenylation element (CPE (zeige CPE Antikörper)) binding factor binds the small intracellular domain (ICD) of APLP1.

  8. The results demonstrated that cell viability and neurite outgrowth of N2a cells undergoing knockdown of Aplp1 were significantly reduced, compared with N2a cells undergoing knockdown of either App (zeige APP Antikörper) or Aplp2 (zeige APLP2 Antikörper).

APLP1 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternative names and synonyms associated with APLP1

  • amyloid beta (A4) precursor-like protein 1 (APLP1) Antikörper
  • amyloid beta (A4) precursor-like protein 1 (aplp1) Antikörper
  • amyloid beta (A4) precursor-like protein 1 (Aplp1) Antikörper
  • APLP Antikörper
  • Aplp1_retired Antikörper
  • MGC115336 Antikörper
  • RGD1561211 Antikörper

Bezeichner auf Proteinebene für APLP1

amyloid-like protein 1 , amyloid beta (A4) precursor-like protein 1 , amyloid-like protein 1-like , APLP-1 , amyloid precursor-like protein 1 , APLP

GENE ID SPEZIES
476478 Canis lupus familiaris
513154 Bos taurus
711258 Macaca mulatta
734469 Xenopus laevis
100060016 Equus caballus
100151735 Xenopus (Silurana) tropicalis
100392661 Callithrix jacchus
100471364 Ailuropoda melanoleuca
100016549 Monodelphis domestica
100583911 Nomascus leucogenys
100614338 Pan troglodytes
333 Homo sapiens
11803 Mus musculus
502317 Rattus norvegicus
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