anti-CFLAR (CFLAR) Antikörper

Bezeichnung:
anti-CASP8 and FADD-Like Apoptosis Regulator Antikörper (CFLAR)
Auf www.antikoerper-online.de finden Sie aktuell 298 CASP8 and FADD-Like Apoptosis Regulator (CFLAR) Antikörper von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CFLAR Proteine (13) und CFLAR Kits (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 341 CFLAR Produkte verfügbar.
Synonyme:
2310024N18Rik, A430105C05Rik, c-Flip, c-FLIPL, c-FLIPR, c-FLIPS, Cash, CASP8AP1, Casper, CFLAR, CLARP, Clarp1, ENSMUSG00000072980, FLAME, FLAME-1, FLAME1, Flip, Gm9845, I-FLICE, MRIT
Alle Antikörper anzeigen Gen GeneID UniProt
CFLAR 8837 O15519
CFLAR 12633 O35732
CFLAR 117279  

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Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-CFLAR (CFLAR) Antikörper

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anti-Human CFLAR Antikörper:

anti-Mouse (Murine) CFLAR Antikörper:

anti-Rat (Rattus) CFLAR Antikörper:

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Am meisten referenzierte anti-CFLAR Antikörper

  1. Human Polyclonal CFLAR Primary Antibody für ELISA, ICC - ABIN4312113 : Kim, Fisher, Xu, el-Deiry: Molecular determinants of response to TRAIL in killing of normal and cancer cells. in Clinical cancer research : an official journal of the American Association for Cancer Research 2000 (PubMed)
    Zeige alle 9 Referenzen für 4312113

  2. Human Monoclonal CFLAR Primary Antibody für IP, WB - ABIN1169019 : Rescigno, Piguet, Valzasina, Lens, Zubler, French, Kindler, Tschopp, Ricciardi-Castagnoli et al.: Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate ... in The Journal of experimental medicine 2000 (PubMed)
    Zeige alle 5 Referenzen für 1169019

  3. Human Polyclonal CFLAR Primary Antibody für IHC (fro), IF - ABIN318973 : Thome, Schneider, Hofmann, Fickenscher, Meinl, Neipel, Mattmann, Burns, Bodmer, Schröter, Scaffidi, Krammer, Peter, Tschopp: Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. in Nature 1997 (PubMed)
    Zeige alle 4 Referenzen für 318973

  4. Human Polyclonal CFLAR Primary Antibody für IHC (p), WB - ABIN401040 : Irmler, Thome, Hahne, Schneider, Hofmann, Steiner, Bodmer, Schröter, Burns, Mattmann, Rimoldi, French, Tschopp: Inhibition of death receptor signals by cellular FLIP. in Nature 1997 (PubMed)
    Zeige alle 4 Referenzen für 401040

  5. Human Monoclonal CFLAR Primary Antibody für EIA, WB - ABIN336100 : Yu, Shi: FLIP and the death effector domain family. in Oncogene 2008 (PubMed)
    Zeige alle 2 Referenzen für 336100

  6. Human Polyclonal CFLAR Primary Antibody für WB - ABIN2792120 : Geserick, Drewniok, Hupe, Haas, Diessenbacher, Sprick, Schön, Henkler, Gollnick, Walczak, Leverkus: Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis. in Oncogene 2008 (PubMed)

  7. Human Polyclonal CFLAR Primary Antibody für FACS, IHC (p) - ABIN653068 : Kim, Pettingell, Jung, Kovacs, Tanzi: Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. in Science (New York, N.Y.) 1998 (PubMed)

  8. Cow (Bovine) Polyclonal CFLAR Primary Antibody für WB - ABIN2792098 : Kondo, Iwase, Watanabe, Uchida, Takaoka, Ohashi, Ito, Nagumo: Enhancement of susceptibility to Fas-mediated apoptosis in HL-60 cells through down-regulation of cellular FLICE-inhibitory protein by phosphatidylinositol 3-kinase inhibitors. in Oncology reports 2005 (PubMed)

Weitere Antikörper gegen CFLAR Interaktionspartner

Human CASP8 and FADD-Like Apoptosis Regulator (CFLAR) Interaktionspartner

  1. findings suggest that expression of cFLIPL regulates the basal interaction of Bcl-2 (zeige BCL2 Antikörper) with Beclin-1 (zeige BECN1 Antikörper) and substantiates p53 (zeige TP53 Antikörper) dependent ubiquitination of Beclin-1 (zeige BECN1 Antikörper) during autophagic stress to determine the fate of cell death or survival.

  2. Using the tDED filament structure as a template, structural analyses reveal the interaction surfaces between FADD (zeige FADD Antikörper) and caspase-8 (zeige CASP8 Antikörper) and the distinct mechanisms of regulation by cFLIP and MC159 through comingling and capping, respectively.

  3. Data in this study show that cFLIPL inhibits IFN regulatory factor 3 (IRF3 (zeige IRF3 Antikörper)), a transcription factor central for IFN-beta (zeige IFNB1 Antikörper) and IFN-stimulated gene expression.

  4. CFLAR levels were substantially decreased in the livers of subjects with NAFLD and NASH, as compared to that in nonsteatotic controls.

  5. association of c-FLIPL and TIP49 (zeige RUVBL1 Antikörper) provided an additional mechanism involved in c-FLIPL-mediated functions, including Wnt (zeige WNT2 Antikörper) activation

  6. CFLAR role in the necroptosis in fibroblasts

  7. TRAIL can enhance RIP1 (zeige UQCRFS1 Antikörper) and c-FLIPL expression in HepG2 cells.

  8. Combined triple actions of the TRAIL, the IAPs inhibitor, AT406, and the c-FLIP expression inhibitor, rocaglamide (ART), markedly improve TRAIL-induced apoptotic effects in most solid cancer cell lines through the activation of an extrinsic apoptosis pathway

  9. Our results postulate that thymoquinone induces apoptosis through downregulating c-FLIP and Bcl-2 (zeige BCL2 Antikörper) which can be utilized as a chemotherapeutic agent to treat renal carcinoma (zeige TSC2 Antikörper).

  10. knockdown of cFLIPL and induced expression of FADD (zeige FADD Antikörper) rapidly accumulate intracellular ROS (zeige ROS1 Antikörper) accompanied by JNK1 (zeige MAPK8 Antikörper) activation to substantiate apoptosis.

Mouse (Murine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) Interaktionspartner

  1. Findings establish CFLAR as a key suppressor of steatohepatitis and indicate that the development of CFLAR-peptide-mimicking drugs and the screening of small-molecular inhibitors that specifically block ASK1 (zeige MAP3K5 Antikörper) dimerization are new and feasible approaches for NASH (zeige SAMSN1 Antikörper) treatment.

  2. knockdown of cFLIPL and induced expression of FADD (zeige FADD Antikörper) rapidly accumulate intracellular ROS (zeige ROS1 Antikörper) accompanied by JNK1 (zeige MAPK8 Antikörper) activation to substantiate apoptosis.

  3. CASP8 (zeige CASP8 Antikörper) is present exclusively as its cleaved p43 (zeige AIMP1 Antikörper) product, bound to cFLIPL.

  4. The generation of mouse line with Flip deficiency in cells that express cre under the CD11c (zeige ITGAX Antikörper) promoter is reported.

  5. c-FLIPL deficiency induces the caspase (zeige CASP3 Antikörper)-mediated processing of RTN4 (zeige RTN4 Antikörper), thus affecting endoplasmic reticulum (ER) shape and coupling to mitochondria. Thus, it was concluded that c-FLIPL is a novel regulator of ER morphology and ER-mitochondria crosstalk.

  6. Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors.

  7. The results reveal a novel inhibitory role of c-FLIP in myeloid cell activation and demonstrate the unexpected anti-inflammatory activity of c-FLIP.

  8. Upon starvation, c-Flip affects lipid accumulation, ER stress and autophagy, thereby pointing to an important role of c-Flip in the adaptive response and ER stress response programs under both normal and pathological conditions.

  9. Flip preserves cardiac functions and inhibits cardiac hypertrophy partially by blocking ASK1 (zeige MAP3K5 Antikörper)/P38 (zeige CRK Antikörper) signaling.

  10. These data suggest that c-FLIP is a negative regulator of intrinsic apoptosis pathway in T lymphocytes.

Cow (Bovine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) Interaktionspartner

  1. results indicate downregulation of cFLIP during structural luteal regression, suggesting that cFLIP plays a survival role in the bovine corpus luteum

  2. Conservation of FLIP's ability to inhibit apoptosis and to downregulate NF-kappaB (zeige NFKB1 Antikörper) activation across species.

Pig (Porcine) CASP8 and FADD-Like Apoptosis Regulator (CFLAR) Interaktionspartner

  1. cellular-Flice like inhibitory protein (cFLIP) long form, plays an anti-apoptotic role in the granulosa cells of healthy follicles of pig ovaries [cFLIP]

  2. Intracellular remodeling with overexpression of pig c (zeige PIGC Antikörper)-FLIP in xenograft cells may decrease the innate cellular responses against xenografts, facilitating long-term xenograft survival.

  3. Intracellular remodeling with the overexpression of c-FLIP(S/L) in xenograft cells may avoid innate cellular attacks against xenografts and facilitate long-term xenograft survival.

  4. Overexpression of c-FLIP in xenograft cells may prevent innate cellular attacks against xenografts opening the window of opportunity for long-term xenograft survival.

CFLAR Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

Alternative names and synonyms associated with CFLAR

  • CASP8 and FADD-like apoptosis regulator a (cflara) Antikörper
  • CASP8 and FADD-like apoptosis regulator (CFLAR) Antikörper
  • CASP8 and FADD-like apoptosis regulator (cflar) Antikörper
  • CASP8 and FADD-like apoptosis regulator (Cflar) Antikörper
  • cellular FLICE-like inhibitory protein (C-FLIP) Antikörper
  • 2310024N18Rik Antikörper
  • A430105C05Rik Antikörper
  • c-Flip Antikörper
  • c-FLIPL Antikörper
  • c-FLIPR Antikörper
  • c-FLIPS Antikörper
  • Cash Antikörper
  • CASP8AP1 Antikörper
  • Casper Antikörper
  • CFLAR Antikörper
  • CLARP Antikörper
  • Clarp1 Antikörper
  • ENSMUSG00000072980 Antikörper
  • FLAME Antikörper
  • FLAME-1 Antikörper
  • FLAME1 Antikörper
  • Flip Antikörper
  • Gm9845 Antikörper
  • I-FLICE Antikörper
  • MRIT Antikörper

Bezeichner auf Proteinebene für CFLAR

FLIP , CASP8 and FADD-like apoptosis regulator , flice/caspase-i inhibitory protein , cellular FLICE-like inhibitory protein , CASP8 and FADD-like apoptosis regulator-like , FADD-like anti-apoptotic molecule , FADD-like antiapoptotic molecule 1 , MACH-related inducer of toxicity , caspase homolog , caspase-eight-related protein , caspase-like apoptosis regulatory protein , caspase-related inducer of apoptosis , inhibitor of FLICE , usurpin beta , usurpin , FLICE-like inhibitory protein

GENE ID SPEZIES
373114 Danio rerio
424080 Gallus gallus
459872 Pan troglodytes
574234 Macaca mulatta
779578 Xenopus (Silurana) tropicalis
780745 Xenopus laevis
100142680 Felis catus
100393782 Callithrix jacchus
100474872 Ailuropoda melanoleuca
100589650 Nomascus leucogenys
8837 Homo sapiens
12633 Mus musculus
488471 Canis lupus familiaris
497199 Bos taurus
117279 Rattus norvegicus
100172025 Pongo abelii
414381 Sus scrofa
Ausgewählte Anbieter für anti-CFLAR (CFLAR) Antikörper
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