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anti-Caspase 8 (CASP8) Antikörper

anti-Caspase 8, Apoptosis-Related Cysteine Peptidase Antikörper (CASP8)
Auf finden Sie aktuell 387 Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Antikörper von 35 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Caspase 8 Kits (67) und Caspase 8 Proteine (27) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 503 Caspase 8 Produkte verfügbar.
ALPS2B, CAP4, Casp-8, CASP8, casp8-A, caspase-8, FLICE, MACH, MCH5, xCaspase-8, zgc:92075
Alle Antikörper anzeigen Gen GeneID UniProt
CASP8 12370 O89110
CASP8 64044  
CASP8 841 Q14790

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Meistgesuchte Reaktivitäten zu anti-Caspase 8 (CASP8) Antikörper

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anti-Mouse (Murine) Caspase 8 Antikörper:

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Am meisten referenzierte anti-Caspase 8 Antikörper

  1. Human Polyclonal Caspase 8 Primary Antibody für IF (cc), IF (p) - ABIN724205 : Wu, Tang, Jiang, Li, Jiang, Liu: PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. in Molecular and cellular biochemistry 2011 (PubMed)
    Zeige alle 10 Referenzen für ABIN724205

  2. Human Monoclonal Caspase 8 Primary Antibody für CyTOF, FACS - ABIN252488 : Berges, Fuchs, Opelz, Daniel, Naujokat: Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms. in Molecular immunology 2009 (PubMed)
    Zeige alle 6 Referenzen für ABIN252488

  3. Mouse (Murine) Polyclonal Caspase 8 Primary Antibody für WB - ABIN223020 : Woods, Burns, Bradford, Ross, Kosyk, Swenberg, Cunningham, Rusyn: WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. in Toxicological sciences : an official journal of the Society of Toxicology 2007 (PubMed)
    Zeige alle 4 Referenzen für ABIN223020

  4. Human Polyclonal Caspase 8 Primary Antibody für ELISA, WB - ABIN1536108 : Liu, Huang, Liu, Li, Yang, Dou, Liu: Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation. in Toxicology in vitro : an international journal published in association with BIBRA 2014 (PubMed)
    Zeige alle 3 Referenzen für ABIN1536108

  5. Human Polyclonal Caspase 8 Primary Antibody für ELISA, WB - ABIN1532005 : Xu, Xu, Zhou, Zhuang, Wang, Boerner, Wu: Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. in The Journal of biological chemistry 2013 (PubMed)
    Zeige alle 3 Referenzen für ABIN1532005

  6. Human Polyclonal Caspase 8 Primary Antibody für IF, WB - ABIN1105679 : Muzio, Chinnaiyan, Kischkel, ORourke, Shevchenko, Ni, Scaffidi, Bretz, Zhang, Gentz, Mann, Krammer, Peter, Dixit: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. in Cell 1996 (PubMed)
    Zeige alle 2 Referenzen für ABIN1105679

  7. Human Polyclonal Caspase 8 Primary Antibody für IHC, WB - ABIN222959 : Mahul-Mellier, Strappazzon, Petiot, Chatellard-Causse, Torch, Blot, Freeman, Kuhn, Garin, Verna, Fraboulet, Sadoul: Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death. in The Journal of biological chemistry 2008 (PubMed)
    Zeige alle 2 Referenzen für ABIN222959

  8. Human Polyclonal Caspase 8 Primary Antibody für FACS, IF - ABIN390474 : Ji, Gu, Hu, Wang, Liang, Xia, Lu, Song, Fu, Wang: Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality. in Human reproduction (Oxford, England) 2009 (PubMed)
    Zeige alle 2 Referenzen für ABIN390474

  9. Human Polyclonal Caspase 8 Primary Antibody für WB - ABIN783312 : Sánchez, Xu, Juo, Kakizaka, Blenis, Yuan: Caspase-8 is required for cell death induced by expanded polyglutamine repeats. in Neuron 1999 (PubMed)
    Zeige alle 2 Referenzen für ABIN783312

Weitere Antikörper gegen Caspase 8 Interaktionspartner

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (zeige AMD1 Antikörper)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (zeige TP53 Antikörper)-overexpressed apoptotic embryos.

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (zeige BID Antikörper) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Statistically significant increases in the expression of Fas (zeige FAS Antikörper) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (zeige DAPK1 Antikörper), Traf3 (zeige TRAF3 Antikörper), Tnsf12, Tnfrsf1A (zeige TNFRSF1A Antikörper) and Ripk1 (zeige RIPK1 Antikörper).

  2. Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (zeige RIPK3 Antikörper))-mediated necroptosis.

  3. we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection

  4. Data indicate that NLRC4 (zeige NLRC4 Antikörper) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (zeige IL18 Antikörper) release, and implicate Caspase-8 in NLRC4 (zeige NLRC4 Antikörper) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (zeige CASP1 Antikörper) and Caspase-8.

  5. ING4 (zeige ING4 Antikörper) might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (zeige FAS Antikörper)-induced apoptosis in a caspase-8-dependent pathway.

  6. studies have uncovered the combined actions of the NLRP3 (zeige NLRP3 Antikörper) inflammasome and caspase 8 leading to IL-1beta (zeige IL1B Antikörper) maturation and the directionality of IL-1beta (zeige IL1B Antikörper) in driving disease inPstpip2(cmo (zeige PSTPIP2 Antikörper))mice.

  7. Chronic TLR Stimulation Controls NLRP3 (zeige NLRP3 Antikörper) Inflammasome Activation through IL-10 (zeige IL10 Antikörper) Mediated Regulation of NLRP3 (zeige NLRP3 Antikörper) Expression and Caspase-8 Activation

  8. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  9. Data indicate that receptor-interacting serine-threonine kinase 3 (RIPK3 (zeige RIPK3 Antikörper)) deletion prevents inflammatory phenotypes in CreLysM (lysozyme (zeige LYZ Antikörper) M) Casp8fl/fl (caspase 8) mice.

  10. CASP8 deletion did not affect the overall number of microglia expressing the pan (zeige SUPT6H Antikörper) specific microglia marker, Iba1 (zeige AIF1 Antikörper)

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Dysregulation of a potassium channel (zeige KCNAB2 Antikörper), THIK-1 (zeige KCNK13 Antikörper), targeted by caspase-8, accelerates cell shrinkage.

  2. caspase-8 and caspase-9 (zeige CASP9 Antikörper) contribute to the cyclic stretch-induced apoptosis, but functioned differently at different stages in human periodontal ligament cells

  3. Down-regulation of mRNA expression was found in cases in which CASP8, TMS1 (zeige SERINC3 Antikörper) and DAPK (zeige DAPK1 Antikörper) were hypermethylated.

  4. High levels of FADD (zeige FADD Antikörper) and caspase-8, but not caspase-3 (zeige CASP3 Antikörper), were associated with increased incidence of coronary events in subjects from the general population.

  5. sorafenib overcomes TRAIL resistance in renal cell carcinoma (zeige MOK Antikörper) by a mechanism that does not rely on Mcl-1 (zeige MCL1 Antikörper) down-regulation but involves ROS (zeige ROS1 Antikörper) accumulation and increased activation of caspase-8

  6. autoinflammation-associated H443P nlrc4 (zeige NLRC4 Antikörper) mutant is altered in interaction with SUG1 (zeige PSMC5 Antikörper) and ubiquitinated proteins, triggering constitutive caspase-8-mediated cell death dependent on FADD (zeige FADD Antikörper) but independent of Ser (zeige SIGLEC1 Antikörper)(533) phosphorylation.

  7. Caspase-8 is phosphorylated on Tyr380 in a Src kinase (zeige CSK Antikörper) dependent manner and this phosphorylation is required for transformation and it is enhanced by hypoxic conditions.

  8. Our results revealed that caspase-8 gene silencing may result from the methylation of its gene promoter in human glioma tissues. The expression of caspase-8 at the mRNA level was significantly associated with the grade of human glioma.

  9. Suggest that caspase 8 SNPs were not associated with rheumatoid arthritis.

  10. novel dynamic interplay between Src (zeige SRC Antikörper) and caspase-8 likely acts as a potent signal-integrating switch directing the cell towards apoptosis or survival

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (zeige CASP3 Antikörper) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

  2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (zeige CASP9 Antikörper).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (zeige STAT1 Antikörper) at Ser (zeige SIGLEC1 Antikörper)-727 and STAT1 (zeige STAT1 Antikörper) binding to the caspase-8 promoter in cultured lung endothelial cells.

  2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (zeige TNF Antikörper), IL-6 (zeige IL6 Antikörper), IL-12p40, IL-1beta (zeige IL1B Antikörper), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (zeige BCL2L1 Antikörper).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Targeted gene knockdown of TNFRSF1B (zeige TNFRSF1B Antikörper) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (zeige CASP2 Antikörper) and P53 (zeige TP53 Antikörper)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (zeige CASP3 Antikörper).

  2. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.

Caspase 8 (CASP8) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Alternative names and synonyms associated with Caspase 8 (CASP8)

  • caspase 8, apoptosis-related cysteine peptidase (casp8) Antikörper
  • death related ced-3/Nedd2-like protein (Dredd) Antikörper
  • caspase 8, apoptosis-related cysteine peptidase (CASP8) Antikörper
  • caspase-8 (AaeL_AAEL014148) Antikörper
  • caspase-8 (casp8) Antikörper
  • caspase 8 (LOC100222284) Antikörper
  • caspase 8 (Casp8) Antikörper
  • caspase 8 (LOC100348477) Antikörper
  • ALPS2B Antikörper
  • CAP4 Antikörper
  • Casp-8 Antikörper
  • CASP8 Antikörper
  • casp8-A Antikörper
  • caspase-8 Antikörper
  • FLICE Antikörper
  • MACH Antikörper
  • MCH5 Antikörper
  • xCaspase-8 Antikörper
  • zgc:92075 Antikörper

Bezeichner auf Proteinebene für CASP8

caspase-8 , xcaspase 8 , death related ced-3/Nedd2-like protein , GLEAN_14026 , caspase 8, apoptosis-related cysteine peptidase , caspase 8 , caspase-8-like , DEATH effector domain caspase , Fas-linked ICE-like protease , FADD-homologous ICE/CED-3-like protease , FADD-like ICE , ICE-like apoptotic protease 5 , MACH-alpha-1/2/3 protein , MACH-beta-1/2/3/4 protein , MORT1-associated ced-3 homolog , apoptotic cysteine protease , apoptotic protease Mch-5 , caspase 8, apoptosis-related cysteine protease , caspase-8a , cysteine protease

373559 Xenopus laevis
661095 Tribolium castaneum
702781 Macaca mulatta
5563818 Aedes aegypti
100049400 Oryzias latipes
100066502 Equus caballus
100142684 Felis catus
100172115 Pongo abelii
100222284 Taeniopygia guttata
100472842 Ailuropoda melanoleuca
100579132 Hydra magnipapillata
100586183 Nomascus leucogenys
12370 Mus musculus
64044 Rattus norvegicus
100348477 Oryctolagus cuniculus
841 Homo sapiens
746477 Pan troglodytes
507481 Bos taurus
395284 Gallus gallus
488473 Canis lupus familiaris
595105 Sus scrofa
101107334 Ovis aries
58022 Danio rerio
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