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anti-Caspase 8 (CASP8) Antikörper

anti-Caspase 8, Apoptosis-Related Cysteine Peptidase Antikörper (CASP8)
Auf finden Sie aktuell 391 Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Antikörper von 35 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Caspase 8 Kits (58) und Caspase 8 Proteine (25) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 494 Caspase 8 Produkte verfügbar.
ALPS2B, CAP4, Casp-8, CASP8, casp8-A, caspase-8, FLICE, MACH, MCH5, xCaspase-8, zgc:92075
Alle Antikörper anzeigen Gen GeneID UniProt
CASP8 12370 O89110
CASP8 64044  
CASP8 841 Q14790

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Meistgesuchte Reaktivitäten zu anti-Caspase 8 (CASP8) Antikörper

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anti-Mouse (Murine) Caspase 8 Antikörper:

anti-Rat (Rattus) Caspase 8 Antikörper:

anti-Human Caspase 8 Antikörper:

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Am meisten referenzierte anti-Caspase 8 Antikörper

  1. Human Polyclonal Caspase 8 Primary Antibody für IF (cc), IF (p) - ABIN724205 : Wu, Tang, Jiang, Li, Jiang, Liu: PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. in Molecular and cellular biochemistry 2011 (PubMed)
    Zeige alle 9 Referenzen für ABIN724205

  2. Cow (Bovine) Polyclonal Caspase 8 Primary Antibody für WB - ABIN222878 : Peluffo, Stouffer, Tesone: Activity and expression of different members of the caspase family in the rat corpus luteum during pregnancy and postpartum. in American journal of physiology. Endocrinology and metabolism 2007 (PubMed)
    Zeige alle 5 Referenzen für ABIN222878

  3. Mouse (Murine) Polyclonal Caspase 8 Primary Antibody für WB - ABIN223020 : Woods, Burns, Bradford, Ross, Kosyk, Swenberg, Cunningham, Rusyn: WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. in Toxicological sciences : an official journal of the Society of Toxicology 2007 (PubMed)
    Zeige alle 4 Referenzen für ABIN223020

  4. Human Polyclonal Caspase 8 Primary Antibody für ELISA, WB - ABIN1532005 : Xu, Xu, Zhou, Zhuang, Wang, Boerner, Wu: Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. in The Journal of biological chemistry 2013 (PubMed)
    Zeige alle 3 Referenzen für ABIN1532005

  5. Human Polyclonal Caspase 8 Primary Antibody für ELISA, WB - ABIN1536108 : Liu, Huang, Liu, Li, Yang, Dou, Liu: Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation. in Toxicology in vitro : an international journal published in association with BIBRA 2014 (PubMed)
    Zeige alle 3 Referenzen für ABIN1536108

  6. Human Polyclonal Caspase 8 Primary Antibody für IF, WB - ABIN1105679 : Muzio, Chinnaiyan, Kischkel, ORourke, Shevchenko, Ni, Scaffidi, Bretz, Zhang, Gentz, Mann, Krammer, Peter, Dixit: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. in Cell 1996 (PubMed)
    Zeige alle 2 Referenzen für ABIN1105679

  7. Human Polyclonal Caspase 8 Primary Antibody für IHC, WB - ABIN222959 : Mahul-Mellier, Strappazzon, Petiot, Chatellard-Causse, Torch, Blot, Freeman, Kuhn, Garin, Verna, Fraboulet, Sadoul: Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death. in The Journal of biological chemistry 2008 (PubMed)
    Zeige alle 2 Referenzen für ABIN222959

  8. Human Polyclonal Caspase 8 Primary Antibody für FACS, IF - ABIN390474 : Ji, Gu, Hu, Wang, Liang, Xia, Lu, Song, Fu, Wang: Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality. in Human reproduction (Oxford, England) 2009 (PubMed)
    Zeige alle 2 Referenzen für ABIN390474

  9. Human Polyclonal Caspase 8 Primary Antibody für WB - ABIN783312 : Sánchez, Xu, Juo, Kakizaka, Blenis, Yuan: Caspase-8 is required for cell death induced by expanded polyglutamine repeats. in Neuron 1999 (PubMed)
    Zeige alle 2 Referenzen für ABIN783312

Weitere Antikörper gegen Caspase 8 Interaktionspartner

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (zeige AMD1 Antikörper)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (zeige TP53 Antikörper)-overexpressed apoptotic embryos.

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (zeige BID Antikörper) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. studies have uncovered the combined actions of the NLRP3 (zeige NLRP3 Antikörper) inflammasome and caspase 8 leading to IL-1beta (zeige IL1B Antikörper) maturation and the directionality of IL-1beta (zeige IL1B Antikörper) in driving disease inPstpip2(cmo (zeige PSTPIP2 Antikörper))mice.

  2. Chronic TLR Stimulation Controls NLRP3 (zeige NLRP3 Antikörper) Inflammasome Activation through IL-10 (zeige IL10 Antikörper) Mediated Regulation of NLRP3 (zeige NLRP3 Antikörper) Expression and Caspase-8 Activation

  3. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  4. Data indicate that receptor-interacting serine-threonine kinase 3 (RIPK3 (zeige RIPK3 Antikörper)) deletion prevents inflammatory phenotypes in CreLysM (lysozyme (zeige LYZ Antikörper) M) Casp8fl/fl (caspase 8) mice.

  5. CASP8 deletion did not affect the overall number of microglia expressing the pan (zeige SUPT6H Antikörper) specific microglia marker, Iba1 (zeige AIF1 Antikörper)

  6. We observed that NDMP generation was dependent on the extrinsic caspase (zeige CASP3 Antikörper) apoptotic pathway (caspase 3 (zeige CASP3 Antikörper) and caspase 8), cAMP activation of PKA but not of Epac (zeige RAPGEF3 Antikörper), and on activation of MLCK (zeige MYLK Antikörper).

  7. Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 (zeige CASP1 Antikörper) and the Noncanonical Caspase-8 Inflammasomes.

  8. Casp8-dependent migration of enterocytes is likely involved in intestinal physiology and inflammation-related pathophysiology.

  9. NLRP3 (zeige NLRP3 Antikörper) inflammasomes directly utilize caspase-8 as both a pro-apoptotic initiator and major IL-1beta (zeige IL1B Antikörper)-converting protease

  10. The non-receptor tyrosine kinase (zeige TNK1 Antikörper) Tec (zeige NR4A3 Antikörper) controls assembly and activity of the noncanonical caspase-8 inflammasome.

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Findings showed that, in MDA-MB-231 cells, casp-8 might play some unusual roles which should be better explored, in order to understand whether it might be identified as a molecular therapeutic target.

  2. Study showed that TRAIL and caspase-8 expression decreased in human osteosarcoma, resulting in increased cell proliferation, and reduced cell apoptosis suggesting they play important roles in the occurrence, development, and prognosis of osteosarcoma.

  3. evidence that Articulatin-D efficiently activates caspase-8 involved in extrinsic pathway of apoptosis induction, which ultimately results in caspase-3 (zeige CASP3 Antikörper)-dependent DNA fragmentation of Jurkat cells.

  4. Copper induces the activation of apoptosis through casp3 (zeige CASP3 Antikörper)/casp8/casp9 (zeige CASP9 Antikörper)/AIF (zeige AIFM1 Antikörper)/TP53 (zeige TP53 Antikörper) signaling pathways. Suggest that apoptosis activation mechanism is dependent on the concentration, time of exposure to Cu and cell type.

  5. our findings indicate that the expression levels of P-GP (zeige ABCB4 Antikörper), MYC (zeige MYC Antikörper), caspase-8, and AKT3 (zeige AKT3 Antikörper) are candidate biomarkers of cell sensitivity to PLKis.

  6. Overexpression of CASP8 is associated with lung cancer.

  7. Thymoquinone inhibitory effects were associated with inhibition of NF-kappaB (zeige NFKB1 Antikörper) and altered expression of its downstream effectors IL-8 (zeige IL8 Antikörper) and its receptors, the anti-apoptotic Bcl-2 (zeige BCL2 Antikörper), Bcl-xL (zeige BCL2L1 Antikörper), X-IAP (zeige ALPI Antikörper), and FLIP, as well as the pro-apoptotic TRAIL-R1, caspase-8, caspase-9 (zeige CASP9 Antikörper), Bcl-xS (zeige BCL2L1 Antikörper), and cytochrome c (zeige CYCS Antikörper).

  8. Direct non-homotypic interactions of HPV18 E2 transactivation domain (TAD (zeige CRTAM Antikörper)) with alpha2/alpha5 helices of procaspase-8 death effector domain-B (DED (zeige AATF Antikörper)-B) mediate cell death in HEK293 cells.

  9. CASP8 rs3769823 and IDH2 (zeige IDH2 Antikörper) rs4561444 were as the potential functional variants in high-linkage disequilibrium with these single nucleotide polymorphisms, respectively. The IDH2 (zeige IDH2 Antikörper) mRNA levels were down-regulated in oesophageal squamous cell carcinoma.

  10. The CASP8 rs700635[C] allele, which is associated with increased risk of cutaneous basal-cell carcinoma and breast cancer, is protective against prostate cancer.

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (zeige CASP3 Antikörper) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

  2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (zeige CASP9 Antikörper).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (zeige STAT1 Antikörper) at Ser (zeige SIGLEC1 Antikörper)-727 and STAT1 (zeige STAT1 Antikörper) binding to the caspase-8 promoter in cultured lung endothelial cells.

  2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (zeige TNF Antikörper), IL-6 (zeige IL6 Antikörper), IL-12p40, IL-1beta (zeige IL1B Antikörper), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (zeige BCL2L1 Antikörper).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Targeted gene knockdown of TNFRSF1B (zeige TNFRSF1B Antikörper) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (zeige CASP2 Antikörper) and P53 (zeige TP53 Antikörper)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (zeige CASP3 Antikörper).

  2. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.

Caspase 8 (CASP8) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Alternative names and synonyms associated with Caspase 8 (CASP8)

  • caspase 8, apoptosis-related cysteine peptidase (casp8) Antikörper
  • death related ced-3/Nedd2-like protein (Dredd) Antikörper
  • caspase 8, apoptosis-related cysteine peptidase (CASP8) Antikörper
  • caspase-8 (AaeL_AAEL014148) Antikörper
  • caspase-8 (casp8) Antikörper
  • caspase 8 (LOC100222284) Antikörper
  • caspase 8 (Casp8) Antikörper
  • caspase 8 (LOC100348477) Antikörper
  • ALPS2B Antikörper
  • CAP4 Antikörper
  • Casp-8 Antikörper
  • CASP8 Antikörper
  • casp8-A Antikörper
  • caspase-8 Antikörper
  • FLICE Antikörper
  • MACH Antikörper
  • MCH5 Antikörper
  • xCaspase-8 Antikörper
  • zgc:92075 Antikörper

Bezeichner auf Proteinebene für CASP8

caspase-8 , xcaspase 8 , death related ced-3/Nedd2-like protein , GLEAN_14026 , caspase 8, apoptosis-related cysteine peptidase , caspase 8 , caspase-8-like , DEATH effector domain caspase , Fas-linked ICE-like protease , FADD-homologous ICE/CED-3-like protease , FADD-like ICE , ICE-like apoptotic protease 5 , MACH-alpha-1/2/3 protein , MACH-beta-1/2/3/4 protein , MORT1-associated ced-3 homolog , apoptotic cysteine protease , apoptotic protease Mch-5 , caspase 8, apoptosis-related cysteine protease , caspase-8a , cysteine protease

373559 Xenopus laevis
661095 Tribolium castaneum
702781 Macaca mulatta
5563818 Aedes aegypti
100049400 Oryzias latipes
100066502 Equus caballus
100142684 Felis catus
100172115 Pongo abelii
100222284 Taeniopygia guttata
100472842 Ailuropoda melanoleuca
100579132 Hydra magnipapillata
100586183 Nomascus leucogenys
12370 Mus musculus
64044 Rattus norvegicus
100348477 Oryctolagus cuniculus
841 Homo sapiens
746477 Pan troglodytes
507481 Bos taurus
395284 Gallus gallus
488473 Canis lupus familiaris
595105 Sus scrofa
101107334 Ovis aries
58022 Danio rerio
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