anti-Caspase 2 (CASP2) Antikörper

anti-Caspase 2, Apoptosis-Related Cysteine Peptidase Antikörper (CASP2)
Auf finden Sie aktuell 220 Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antikörper von 32 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Caspase 2 Kits (29) und Caspase 2 Proteine (25) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 283 Caspase 2 Produkte verfügbar.
CASP-2, Caspase-2, ICH-1, ICH-1L/1S, ICH1, ICH1L1S, NEDD-2, NEDD2, PPP1R57, xCaspase-2

Meistgesuchte Reaktivitäten zu anti-Caspase 2 (CASP2) Antikörper

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anti-Rat (Rattus) Caspase 2 Antikörper:

anti-Mouse (Murine) Caspase 2 Antikörper:

anti-Human Caspase 2 Antikörper:

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Am meisten referenzierte anti-Caspase 2 Antikörper

  1. Human Monoclonal Caspase 2 Primary Antibody für IF, WB - ABIN968323 : Guo, Srinivasula, Druilhe, Fernandes-Alnemri, Alnemri: Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. in The Journal of biological chemistry 2002 (PubMed)
    Zeige alle 5 Referenzen für 968323

  2. Human Polyclonal Caspase 2 Primary Antibody für FACS, IHC (p) - ABIN388122 : Shi, Vivian, Lee, Ge, Morotomi-Yano, Manzl, Bock, Sato, Tomomori-Sato, Zhu, Haug, Swanson, Washburn, Chen, Chen, Villunger, Florens, Du: DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance. in Cell 2009 (PubMed)
    Zeige alle 3 Referenzen für 388122

  3. Human Polyclonal Caspase 2 Primary Antibody für IHC, WB - ABIN222882 : Basu, Adkins, Basu: Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway. in Cancer research 2008 (PubMed)
    Zeige alle 2 Referenzen für 222882

  4. Human Polyclonal Caspase 2 Primary Antibody für ELISA, WB - ABIN1536102 : Wang, Miura, Bergeron, Zhu, Yuan: Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. in Cell 1994 (PubMed)
    Zeige alle 2 Referenzen für 1536102

  5. Human Polyclonal Caspase 2 Primary Antibody für IHC, ELISA - ABIN1531645 : Hillier, Fulton, Fulton, Graves, Pepin, Wagner-McPherson, Layman, Maas, Jaeger, Walker, Wylie, Sekhon, Becker, OLaughlin, Schaller, Fewell, Delehaunty, Miner, Nash, Cordes, Du, Sun, Edwards et al.: The DNA sequence of human chromosome 7. ... in Nature 2003 (PubMed)
    Zeige alle 2 Referenzen für 1531645

  6. Human Polyclonal Caspase 2 Primary Antibody für IHC (p), WB - ABIN1105674 : Bergeron, Perez, Macdonald, Shi, Sun, Jurisicova, Varmuza, Latham, Flaws, Salter, Hara, Moskowitz, Li, Greenberg, Tilly, Yuan: Defects in regulation of apoptosis in caspase-2-deficient mice. in Genes & development 1998 (PubMed)
    Zeige alle 2 Referenzen für 1105674

Weitere Antikörper gegen Caspase 2 Interaktionspartner

Xenopus laevis Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Interaktionspartner

  1. caspase-2 has a role as an initiator caspase (zeige CASP3 Antikörper) in lipoapoptosis

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (zeige BID Antikörper) and Caspases-2 and -8

  3. Caspase-2 phosphorylated at S135 binds 14-3-3zeta (zeige YWHAZ Antikörper), thus preventing C2 dephosphorylation.

  4. The data demonstrate that cell death is prevented during mitosis through the inhibitory phosphorylation of caspase-2 and suggest that under conditions of mitotic arrest, cdk1 (zeige CDK1 Antikörper)-cyclin B1 (zeige CCNB1 Antikörper) activity must be overcome for apoptosis to occur.

Mouse (Murine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Interaktionspartner

  1. We further generated Casp2(C320S) mutant mice to demonstrate that caspase-2 catalytic activity is essential for its function in limiting aneuploidy. Our results provide direct evidence that the apoptotic activity of caspase-2 is necessary for deleting cells with mitotic aberrations to limit aneuploidy

  2. These results provide the first evidence of caspase-2 in regulating haematopoietic stem cell and progenitor differentiation, as well as aneuploidy, in vivo.

  3. Study describes a novel pathological process in which caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines.

  4. Caspase-2 deficiency protected mice from diet-induced obesity, metabolic syndrome and nonalcoholic fatty liver disease.

  5. The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein (zeige HOMER1 Antikörper) Raidd (zeige CRADD Antikörper)

  6. Data show that indoles can effectively suppress acute hepatic inflammation caused by staphylococcal enterotoxin B (SEB) maybe mediated by decreased expression of miR-31 and caspase-2-dependent apoptosis in T cells.

  7. Data indicate that the nucleotide-binding domain and leucine-rich repeat containing (zeige NLRX1 Antikörper) (NLRP3 (zeige NLRP3 Antikörper))-caspase-2 axis drives general endoplasmic reticulum (ER) stress-induced inflammasome activation.

  8. these studies elucidate a Caspase-2-p53 (zeige TP53 Antikörper) signaling network that impacts lung tumorigenesis and chemotherapy response in vivo.

  9. data strongly suggest that caspase-2 deficiency leads to increased cellular stress largely because these mice fail to respond to oxidative stress by upregulating their antioxidant defense mechanism

  10. These results demonstrate an important role for caspase-2 in regulating proteome and metabolome remodelling during ageing.

Human Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Interaktionspartner

  1. NPM1 (zeige NPM1 Antikörper)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 activation cascade.

  2. Sensitization of colon carcinoma cells to radiation-induced cell death and DNA-damage by HuR (zeige ELAVL1 Antikörper) knockdown critically depends on caspase-2.

  3. BCL9L (zeige BCL9L Antikörper) dysfunction contributes to aneuploidy tolerance in both TP53 (zeige TP53 Antikörper)-WT and mutant cells by reducing basal caspase-2 levels and preventing cleavage of MDM2 (zeige MDM2 Antikörper) and BID (zeige BID Antikörper).

  4. CASP2 down-regulation had a reverse relationship with miR (zeige MLXIP Antikörper)-383 down-regulation in regulating epithelial ovarian cancer development.

  5. Results suggest that mutations at all three cleavage sites of caspase-2 protein neither affect the macromolecular core complex assembly, nor modify caspase-2 activity upon DNA damage. Consequently, caspase-2 activation occurs in the macromolecular complex without its dissociation.

  6. These findings indicate that miR (zeige MLXIP Antikörper)-125a-5p decreases after HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.

  7. these studies elucidate a Caspase-2-p53 (zeige TP53 Antikörper) signaling network that impacts lung tumorigenesis and chemotherapy response in vivo.

  8. We have also demonstrated that these correlations are tissue specific being reduced (CASP9 (zeige CASP9 Antikörper) and CASP10 (zeige CASP10 Antikörper)) or different (CASP2) in the liver

  9. the initiator caspase-2 is required for robust death of ovarian cancer cells induced by FASN (zeige FASN Antikörper) inhibitors

  10. HuR (zeige ELAVL1 Antikörper) sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by upregulating the translation of caspase-2.

Cow (Bovine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Interaktionspartner

  1. EtOH-induced mitochondria-mediated apoptosis is initiated by caspase-2 activation, which is regulated by CoQ10

  2. the capacity for blastocysts to undergo further development is related to degree of group II caspase (zeige CASP3 Antikörper) activity

Pig (Porcine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Interaktionspartner

  1. hypoxia/re-oxygenation injury in cultured proximal tubule cells induced apoptosis by activation of caspase-2, which is required for the mitochondrial translocation of Bax (zeige BAX Antikörper).

Caspase 2 (CASP2) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Caspase 2 (CASP2)

  • caspase-2-like (LOC100050611) Antikörper
  • caspase-2 (xCaspase-2) Antikörper
  • caspase-2 (CpipJ_CPIJ008254) Antikörper
  • caspase 2 (Casp2) Antikörper
  • caspase 2 (LOC100101590) Antikörper
  • caspase 2, apoptosis-related cysteine peptidase (CASP2) Antikörper
  • caspase 2, apoptosis-related cysteine peptidase (Casp2) Antikörper
  • caspase-2-like (LOC100521118) Antikörper
  • CASP-2 Antikörper
  • Caspase-2 Antikörper
  • ICH-1 Antikörper
  • ICH-1L/1S Antikörper
  • ICH1 Antikörper
  • ICH1L1S Antikörper
  • NEDD-2 Antikörper
  • NEDD2 Antikörper
  • PPP1R57 Antikörper
  • xCaspase-2 Antikörper

Bezeichner auf Proteinebene für CASP2

caspase-2 , CASP-2 , ICH-1 protease , protease ICH-1 , NEDD-2 , neural precursor cell expressed developmentally down-regulated protein 2 , protein phosphatase 1, regulatory subunit 57 , caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) , ICH1 protease , caspase 2, apoptosis-related cysteine protease , cysteine protease caspase-2

100050611 Equus caballus
397817 Xenopus laevis
6040179 Culex quinquefasciatus
64314 Rattus norvegicus
12366 Mus musculus
100101590 Oryctolagus cuniculus
835 Homo sapiens
482737 Canis lupus familiaris
531419 Bos taurus
395857 Gallus gallus
100735399 Cavia porcellus
100521118 Sus scrofa
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