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TRIP10 Antikörper (AA 411-501)

TRIP10 Reaktivität: Human, Maus, Ratte, Hund WB, IF Wirt: Maus Monoclonal 21-CIP4 unconjugated
Produktnummer ABIN968876
  • Target Alle TRIP10 Antikörper anzeigen
    TRIP10 (Thyroid Hormone Receptor Interactor 10 (TRIP10))
    Bindungsspezifität
    • 15
    • 9
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 411-501
    Reaktivität
    • 47
    • 34
    • 14
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte, Hund
    Wirt
    • 61
    • 1
    Maus
    Klonalität
    • 60
    • 2
    Monoklonal
    Konjugat
    • 28
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TRIP10 Antikörper ist unkonjugiert
    Applikation
    • 48
    • 23
    • 13
    • 13
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Hund, Maus, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human CIP4 aa. 411-501
    Klon
    21-CIP4
    Isotyp
    IgG1
    Top Product
    Discover our top product TRIP10 Primärantikörper
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    Related Products: ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Richnau, Aspenström: "Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1." in: The Journal of biological chemistry, Vol. 276, Issue 37, pp. 35060-70, (2001) (PubMed).

    Tian, Nelson, Stewart: "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules." in: The Journal of biological chemistry, Vol. 275, Issue 11, pp. 7854-61, (2000) (PubMed).

    Aspenström: "A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton." in: Current biology : CB, Vol. 7, Issue 7, pp. 479-87, (1997) (PubMed).

  • Target
    TRIP10 (Thyroid Hormone Receptor Interactor 10 (TRIP10))
    Andere Bezeichnung
    Cip4 (TRIP10 Produkte)
    Synonyme
    CIP4 antikoerper, HSTP antikoerper, STOT antikoerper, STP antikoerper, AI646975 antikoerper, Cip4 antikoerper, trip10 antikoerper, thyroid hormone receptor interactor 10 antikoerper, thyroid hormone receptor interactor 10a antikoerper, TRIP10 antikoerper, Trip10 antikoerper, trip10a antikoerper
    Hintergrund
    Rho family members are small GTP binding proteins that serve as molecular switches for a number of biological processes. They cycle between active GTP-bound and inactive GDP-bound states. CDC42 is a Rho family protein that was identified in membranes of human platelets and placenta. It is the homologue of CDC42Sc, which regulates initiation of bud-site assembly in Saccharomyces cerevisiae. Similarly, CDC42 regulates the function of the mammalian actin cytoskeleton, allowing for efficient cytokinesis and cell morphogenesis. CDC42-interacting protein 4 (CIP4) was identified in a yeast-two hybrid screen for proteins that bind CDC42. Another variant of CIP4, CIP4/2, was identified that contains an extra 56 amino acids and has 71% identity with CIP4 (or CIP4/1). CIP4 contains a C-terminal SH3 domain and an N-terminal domain that is homologous to non-catalyitic motifs in the tyrosine kinase Fer. The mRNA expression of CIP4 is highest in skeletal muscle, heart, and placenta. Overexpression of CIP4 in Swiss 3T3 cells reduces the amount of stress fibers and leads to clustering of CIP4 to foci at the dorsal side of the cells. In addition, CIP4 binds the Rho-GTPase activating protein RICH and the cytoskeletal protein WASP. Coexpression of CIP4 and WASP in Cos-7 cells leads to WASP association with microtubules. Thus, CIP4 is involved in various protein-protein interactions associated with cytoskeletal dynamics. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    80 kDa
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