Glucocorticoid Receptor Antikörper (AA 176-289)
-
- Target Alle Glucocorticoid Receptor (NR3C1) Antikörper anzeigen
- Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))
-
Bindungsspezifität
- AA 176-289
-
Reaktivität
- Human
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser Glucocorticoid Receptor Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI)
- Produktmerkmale
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Human Glucocorticoid Receptor alpha aa. 176-289
- Klon
- 41-Glucocorticoid Receptor
- Isotyp
- IgG1
- Top Product
- Discover our top product NR3C1 Primärantikörper
-
-
- Kommentare
-
Related Products: ABIN967389, ABIN968535
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store undiluted at -20°C.
-
-
DNA binding of the glucocorticoid receptor is not essential for survival." in: Cell, Vol. 93, Issue 4, pp. 531-41, (1998) (PubMed).
: "Steroid hormone receptors: many actors in search of a plot." in: Cell, Vol. 83, Issue 6, pp. 851-7, (1996) (PubMed).
: "Primary structure and expression of a functional human glucocorticoid receptor cDNA." in: Nature, Vol. 318, Issue 6047, pp. 635-41, (1986) (PubMed).
: "
-
DNA binding of the glucocorticoid receptor is not essential for survival." in: Cell, Vol. 93, Issue 4, pp. 531-41, (1998) (PubMed).
-
- Target
- Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))
- Andere Bezeichnung
- Glucocorticoid Receptor (NR3C1 Produkte)
- Synonyme
- GR antikoerper, gcr antikoerper, grl antikoerper, xGR antikoerper, gccr antikoerper, gr antikoerper, zgc:113038 antikoerper, NR3C1 antikoerper, GCL antikoerper, LOC100302444 antikoerper, Gcr antikoerper, Grl antikoerper, Grl-1 antikoerper, Grl1 antikoerper, GRL antikoerper, GCCR antikoerper, GCR antikoerper, NO antikoerper, GR-A antikoerper, nr3c1 antikoerper, nuclear receptor subfamily 3 group C member 1 antikoerper, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) antikoerper, nuclear receptor subfamily 3, group C, member 1 antikoerper, glucocorticoid receptor antikoerper, NR3C1 antikoerper, nr3c1 antikoerper, LOC100302444 antikoerper, Nr3c1 antikoerper
- Hintergrund
- Steroid hormone receptors are hormone activated transcriptional regulators that influence genes required for embryonic development and adult homeostasis. One member of the steroid hormone family is the glucocorticoid receptor. It contains AF1 and AF2 transactivation domains, a DNA binding domain, and ligand binding domain. Ligand bound glucocorticoid receptors dimerize at specific palindromic sequences called glucocorticoid response elements (GREs) in the cis-regulatory region of target genes. Both AF1 and AF2 may be important for initiation or regulation of transcription by interacting with components of the initiation complex or other intermediary factors. In addition to transactivation, glucocorticoid receptors may also regulate transcription through transrepression of target genes. Although mechanisms of transrepression are not completely understood, DNA binding alone, DNA binding plus interaction with other transcription factors, or protein-protein interaction without DNA binding are mechanisms that have been implicated. Thus, glucocorticoid receptors function in the regulation of specific genes that are essential for human development and homeostasis. This antibody is routinely tested by western blot analysis.
- Molekulargewicht
- 94 kDa
- Pathways
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process
-