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PP5 Antikörper (AA 36-238)

PPP5C Reaktivität: Human, Ratte, Maus, Hund WB, IF Wirt: Maus Monoclonal 3-PP5 unconjugated
Produktnummer ABIN968321
  • Target Alle PP5 (PPP5C) Antikörper anzeigen
    PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))
    Bindungsspezifität
    • 11
    • 8
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 36-238
    Reaktivität
    • 75
    • 12
    • 11
    • 7
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    Human, Ratte, Maus, Hund
    Wirt
    • 41
    • 34
    Maus
    Klonalität
    • 43
    • 32
    Monoklonal
    Konjugat
    • 36
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PP5 Antikörper ist unkonjugiert
    Applikation
    • 65
    • 31
    • 27
    • 23
    • 22
    • 11
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Maus, Human, Hund
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat PP5 aa. 36-238
    Klon
    3-PP5
    Isotyp
    IgG1
    Top Product
    Discover our top product PPP5C Primärantikörper
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    Related Products: ABIN968545, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Das, Cohen, Barford: "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions." in: The EMBO journal, Vol. 17, Issue 5, pp. 1192-9, (1998) (PubMed).

    Ollendorff, Donoghue: "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32011-8, (1998) (PubMed).

    Zuo, Dean, Honkanen: "Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12250-8, (1998) (PubMed).

    Becker, Kentrup, Klumpp, Schultz, Joost: "Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain." in: The Journal of biological chemistry, Vol. 269, Issue 36, pp. 22586-92, (1994) (PubMed).

    Chen, McPartlin, Brown, Chen, Barker, Cohen: "A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus." in: The EMBO journal, Vol. 13, Issue 18, pp. 4278-90, (1994) (PubMed).

  • Target
    PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))
    Andere Bezeichnung
    PP5 (PPP5C Produkte)
    Synonyme
    PP5 antikoerper, PPP5 antikoerper, PPT antikoerper, AU020526 antikoerper, pp5 antikoerper, MGC89961 antikoerper, fc83f08 antikoerper, im:7146608 antikoerper, wu:fc83f08 antikoerper, zgc:110801 antikoerper, PPP5C antikoerper, protein phosphatase 5 catalytic subunit antikoerper, protein phosphatase 5, catalytic subunit antikoerper, protein phosphatase 5, catalytic subunit S homeolog antikoerper, serine/threonine-protein phosphatase 5 antikoerper, PPP5C antikoerper, Ppp5c antikoerper, ppp5c.S antikoerper, ppp5c antikoerper, LOC592155 antikoerper, LOC100513542 antikoerper, LOC100564151 antikoerper, LOC100186268 antikoerper, LOC100208775 antikoerper
    Hintergrund
    Phosphorylation and dephosphorylation on serine and threonine residues is critical for signal transduction and the regulation of numerous cellular functions. Phosphorylation levels are modulated by protein kinases and phosphatases. The Ser/Thr phosphatase PP5 (also known as PPT) is a model protein of the fourth subfamily of the PPP-family of phosphatases which includes PP1, PP2A, and PP2B. PP5 is primarily located in the nucleus, demonstrates widespread tissue distribution, and is highly conserved among species. It consists of a C-terminal catalytic domain and an N-terminal TPR (tetratricopeptide repeat) domain which is involved in protein-protein interactions. The TPRs of PP5 mediate protein phosphatase activity. TPRs mediate the interaction of PP5 with various proteins including the hsp90-glucocorticoid receptor complex and the kinase domain of ANP-guanylate cyclase receptor. PP5 is thought to be important in cell growth. For example, it functions upstream of p53 to regulate p21/WAF1/Cip1-mediated G1 growth arrest. Thus, PP5 is a nuclear protein phosphatase that is involved in signaling pathways of cell growth and arrest. This antibody is routinely tested by western blot analysis.
    Synonyms: PPT
    Molekulargewicht
    58 kDa
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