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TIAL1 Antikörper (AA 161-365)

TIAL1 Reaktivität: Human, Maus, Ratte, Hund, Frosch WB, IHC, IP, IF Wirt: Maus Monoclonal 6-TIAR unconjugated
Produktnummer ABIN967917
  • Target Alle TIAL1 Antikörper anzeigen
    TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))
    Bindungsspezifität
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 161-365
    Reaktivität
    • 26
    • 14
    • 11
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Frosch
    Wirt
    • 21
    • 4
    • 1
    Maus
    Klonalität
    • 24
    • 2
    Monoklonal
    Konjugat
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TIAL1 Antikörper ist unkonjugiert
    Applikation
    • 13
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Kreuzreaktivität
    Maus, Ratte (Rattus), Hund, Frosch
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human TIAR aa. 161-365
    Klon
    6-TIAR
    Isotyp
    IgG1
    Top Product
    Discover our top product TIAL1 Primärantikörper
  • Kommentare

    Related Products: ABIN968555, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Taupin, Tian, Kedersha, Robertson, Anderson: "The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 5, pp. 1629-33, (1995) (PubMed).

    Kawakami, Tian, Duan, Streuli, Schlossman, Anderson: "Identification and functional characterization of a TIA-1-related nucleolysin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8681-5, (1992) (PubMed).

  • Target
    TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))
    Andere Bezeichnung
    TIAR (TIAL1 Produkte)
    Synonyme
    TCBP antikoerper, TIAR antikoerper, 5330433G13Rik antikoerper, AL033329 antikoerper, mTIAR antikoerper, zgc:66130 antikoerper, tcbp antikoerper, tiar antikoerper, TIA1 cytotoxic granule associated RNA binding protein like 1 antikoerper, Tia1 cytotoxic granule-associated RNA binding protein-like 1 antikoerper, TIA1 cytotoxic granule-associated RNA binding protein-like 1 antikoerper, TIAL1 antikoerper, Tial1 antikoerper, tial1 antikoerper
    Hintergrund
    TIAR is an RNA-binding protein related to TIA-1. Both proteins are candidate effectors of apoptotic cell death and consist of three N-terminal RNA-recognition motifs (RRM) and a C-terminal protein-interaction domain (PID). Unlike TIA-1, which is localized in the granules of cytotoxic lymphocytes, TIAR is predominantly found in the nucleus of many different cell types. Two related isoforms (42 kDa and 50 kDa) of TIAR have been identified. It has been demonstrated that TIAR can trigger DNA fragmentation in permeabilized thymocytes, suggesting that it may be an effector of apoptotic cell death. During Fas-mediated apoptosis, TIAR shows a rapid translocation from the nucleus to the cytoplasm. This redistribution of TIAR appears to be a specific event and possibly a general feature of the apoptotic program.
    Molekulargewicht
    50 & 42 kDa
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