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NOS1 Antikörper (AA 1095-1289)

NOS1 Reaktivität: Human, Ratte, Maus, Hund WB, IHC, IF, IP Wirt: Maus Monoclonal 16-nNOS-NOS Type I unconjugated
Produktnummer ABIN967895
  • Target Alle NOS1 Antikörper anzeigen
    NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))
    Bindungsspezifität
    • 27
    • 15
    • 12
    • 9
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1095-1289
    Reaktivität
    • 128
    • 90
    • 63
    • 15
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus, Hund
    Wirt
    • 134
    • 21
    • 3
    Maus
    Klonalität
    • 128
    • 30
    Monoklonal
    Konjugat
    • 70
    • 20
    • 11
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NOS1 Antikörper ist unkonjugiert
    Applikation
    • 118
    • 61
    • 48
    • 32
    • 28
    • 27
    • 26
    • 20
    • 19
    • 12
    • 8
    • 6
    • 5
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Kreuzreaktivität
    Ratte (Rattus), Maus, Hund
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human nNOS aa. 1095-1289
    Klon
    16-nNOS-NOS Type I
    Isotyp
    IgG2a
    Top Product
    Discover our top product NOS1 Primärantikörper
  • Kommentare

    Related Products: ABIN967389, ABIN968545

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Schuh, Uldrijan, Telkamp, Rothlein, Neyses: "The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I." in: The Journal of cell biology, Vol. 155, Issue 2, pp. 201-5, (2001) (PubMed).

    Sasaki, Gonzalez-Zulueta, Huang, Herring, Ahn, Ginty, Dawson, Dawson: "Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 15, pp. 8617-22, (2000) (PubMed).

    Yu, Shao, Qian, George, Rockey: "Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension." in: The Journal of clinical investigation, Vol. 105, Issue 6, pp. 741-8, (2000) (PubMed).

    Nathan: "Nitric oxide as a secretory product of mammalian cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 6, Issue 12, pp. 3051-64, (1992) (PubMed).

    Bredt, Hwang, Glatt, Lowenstein, Reed, Snyder: "Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase." in: Nature, Vol. 351, Issue 6329, pp. 714-8, (1991) (PubMed).

  • Target
    NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))
    Andere Bezeichnung
    nNOS/NOS Type I (NOS1 Produkte)
    Synonyme
    NOS1 antikoerper, IHPS1 antikoerper, N-NOS antikoerper, NC-NOS antikoerper, NOS antikoerper, bNOS antikoerper, nNOS antikoerper, 2310005C01Rik antikoerper, NO antikoerper, NOS-I antikoerper, Nos-1 antikoerper, nos antikoerper, ihps1 antikoerper, nnos antikoerper, nos1 antikoerper, nos1-A antikoerper, nanos C2HC-type zinc finger 1 antikoerper, nitric oxide synthase 1 antikoerper, nitric oxide synthase 1, neuronal antikoerper, nitric oxide synthase 1 (neuronal) antikoerper, nitric oxide synthase 1 L homeolog antikoerper, NANOS1 antikoerper, NOS1 antikoerper, Nos1 antikoerper, nos1 antikoerper, nos1.L antikoerper
    Hintergrund
    Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In neurons and endothelial cells, constitutive NOS (cNOS) is activated by agonists that increase intracellular Ca2+ levels and enhance calmodulin binding. Neuronal NOS (nNOS or bNOS) and endothelial NOS (ECNOS) have recognition sites for NADPH, FAD, FMN, and calmodulin and are regulated in a similar manner. However, both have been shown to be distinct gene products of about 155 kDa and 140 kDa, respectively, and the human forms show 52% amino acid identity. Neuronal NOS and induced macrophage NOS (iNOS) share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain. Neuronal NOS, a cytosolic protein present mainly in neural tissues, has been purified and characterized from rat cerebellum. The NO synthesized by this enzyme acts as a neurotransmitter. ECNOS has been cloned from human vascular endothelium as well as from bovine aortic endothelial cells (BAEC) and has a unique N-myristylation consensus sequence that may explain its membrane localization. This antibody is routinely tested by western blot analysis.
    Synonyms: NOS Type I, Neuronal Nitric Oxide Synthase
    Molekulargewicht
    155 kDa
    Pathways
    Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction
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