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CNTNAP1 Antikörper (AA 1-1513)

CNTNAP1 Reaktivität: Human, Maus, Ratte, Hund, Huhn, Frosch WB, IHC, IP, IF Wirt: Maus Monoclonal 30-p190 unconjugated
Produktnummer ABIN967780
  • Target Alle CNTNAP1 Antikörper anzeigen
    CNTNAP1 (Contactin Associated Protein 1 (CNTNAP1))
    Bindungsspezifität
    • 16
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-1513
    Reaktivität
    • 54
    • 24
    • 16
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Huhn, Frosch
    Wirt
    • 51
    • 5
    • 2
    Maus
    Klonalität
    • 52
    • 6
    Monoklonal
    Konjugat
    • 21
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CNTNAP1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 18
    • 15
    • 14
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Kreuzreaktivität
    Hund, Ratte (Rattus), Maus, Huhn, Frosch
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human p190 aa. 1-1513
    Klon
    30-p190
    Isotyp
    IgG1
    Top Product
    Discover our top product CNTNAP1 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Maddox, Burridge: "RhoA is required for cortical retraction and rigidity during mitotic cell rounding." in: The Journal of cell biology, Vol. 160, Issue 2, pp. 255-65, (2003) (PubMed).

    Wolf, Draghi, Liang, Dai, Uhrbom, Eklöf, Westermark, Holland, Resh: "p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3." in: Genes & development, Vol. 17, Issue 4, pp. 476-87, (2003) (PubMed).

    Brandt, Gimona, Hillmann, Haller, Mischak: "Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway." in: The Journal of biological chemistry, Vol. 277, Issue 23, pp. 20903-10, (2002) (PubMed).

    Nakahara, Mueller, Nomizu, Yamada, Yeh, Chen: "Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 9-12, (1998) (PubMed).

    Settleman, Narasimhan, Foster, Weinberg: "Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus." in: Cell, Vol. 69, Issue 3, pp. 539-49, (1992) (PubMed).

  • Target
    CNTNAP1 (Contactin Associated Protein 1 (CNTNAP1))
    Andere Bezeichnung
    p190 (CNTNAP1 Produkte)
    Synonyme
    CNTNAP1 antikoerper, CASPR antikoerper, CNTNAP antikoerper, NRXN4 antikoerper, P190 antikoerper, Caspr antikoerper, AI841080 antikoerper, NCP1 antikoerper, Nrxn4 antikoerper, p190 antikoerper, shm antikoerper, contactin associated protein 1 antikoerper, contactin associated protein-like 1 antikoerper, CNTNAP1 antikoerper, cntnap1 antikoerper, Cntnap1 antikoerper
    Hintergrund
    GTPase activating proteins (GAPs) stimulate the GTP-hydrolyzing activity of GTPases, such as p21[ ras]. Ras-GAP (120kDa) is perhaps the best characterized GAP. p190 is a Ras-GAP associated protein that is tyrosine phosphorylated in transformed and growth factor-stimulated cells. Ras-GAP and p190 are targets of oncoproteins and growth factor receptors. Recombinant p190 enhances GTPase activity of the rho family of GTPases. The complete sequence of p190 exhibits three major regions: an N-terminal region with homology to all GTPases, a middle region homologous to transcriptional repressors, and a C-terminal region the is similar to n-chimerin and other small GTPases.
    Molekulargewicht
    190 kDa
    Pathways
    Cell-Cell Junction Organization
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